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The Role of Glutamate Receptors in Epilepsy [PDF]
Biomedicines, 2023 Glutamate is an essential excitatory neurotransmitter in the central nervous system, playing an indispensable role in neuronal development and memory formation. The dysregulation of glutamate receptors and the glutamatergic system is involved in numerous
Tsang-Shan Chen +3 more
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The role of glutamate receptors in the regulation of the tumor microenvironment
Frontiers in Immunology, 2023 Glutamate, as one of the most important carbon sources in the TCA cycle, is central in metabolic processes that will subsequently influence tumor progression.
Stephane Koda +8 more
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Cross-talk and regulation between glutamate and GABAB receptors [PDF]
Frontiers in Cellular Neuroscience, 2015 Brain function depends on co-ordinated transmission of signals from both excitatory and inhibitory neurotransmitters acting upon target neurons.
Sriharsha eKantamneni
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A Review of Molecular Imaging of Glutamate Receptors
Molecules, 2020 Molecular imaging with positron emission tomography (PET) and single photon emission computed tomography (SPECT) is a well-established and important in vivo technique to evaluate fundamental biological processes and unravel the role of neurotransmitter ...
Jong-Hoon Kim +3 more
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Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors
Frontiers in Molecular Neuroscience, 2019 Pain is an essential protective mechanism meant to prevent tissue damages in organisms. On the other hand, chronic or persistent pain caused, for example, by inflammation or nerve injury is long lasting and responsible for long-term disability in ...
Vanessa Pereira, Cyril Goudet
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Ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors
Frontiers in Molecular Neuroscience, 2015 Changes in synaptic strength underlie the basis of learning and memory and are controlled, in part, by the insertion or removal of AMPA-type glutamate receptors at the postsynaptic membrane of excitatory synapses.
Marisa S Goo +2 more
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Two Signaling Modes Are Better than One: Flux-Independent Signaling by Ionotropic Glutamate Receptors Is Coming of Age [PDF]
BiomedicinesGlutamate is the major excitatory neurotransmitter in the central nervous system. Glutamatergic transmission can be mediated by ionotropic glutamate receptors (iGluRs), which mediate rapid synaptic depolarization that can be associated with Ca2+ entry ...
Valentina Brunetti +6 more
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Plants, 2022 Most excitatory impulses received by neurons are mediated by ionotropic glutamate receptors (iGluRs). These receptors are located at the apex and play an important role in memory, neuronal development, and synaptic plasticity.
Ruphi Naz +7 more
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Science Advances, 2021 Glutamate has dual roles in metabolism and signaling; thus, signaling functions must be isolatable and distinct from metabolic fluctuations, as seen in low-glutamate domains at synapses.
Jacob Moe-Lange +18 more
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Synaptic NMDA receptors mediate hypoxic excitotoxic death [PDF]
, 2012 Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia.
Eisenman, Larry +3 more
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