Results 131 to 140 of about 2,596,775 (326)

Modeling the use of transient ligand binding information by AMPA receptors

npj Systems Biology and Applications
Glutamate mediates fast excitatory neurotransmission through α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors in the central nervous system.
Helena Braunstein, Alejandra C. Ventura, Alejandro Colman-Lerner   +2 more
doaj   +1 more source

Test–retest reproducibility of the metabotropic glutamate receptor 5 ligand [18F]FPEB with bolus plus constant infusion in humans

, 2015
Eunkyung Park, Jenna M. Sullivan, Beata Planeta, Jean‐Dominique Gallezot, Keunpoong Lim, Shu-fei Lin, Jim Ropchan, Timothy J. McCarthy, Yu‐Shin Ding, Evan D. Morris, Wendol Williams, Yiyun Huang, Richard E. Carson   +12 more
openalex   +2 more sources

Spontaneous Glutamate Release Is Independent of Calcium Influx and Tonically Activated by the Calcium-Sensing Receptor [PDF]

, 2011
Nicholas P. Vyleta, Stephen M. Smith
openalex   +1 more source

Flipping the Switch: MeCP2‐Mediated Lactylation Rewires Microglial Metabolism and Inflammation via the HK2/mTOR Axis in Poststroke Neuroinflammation

Advanced Science, EarlyView.
Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang, Shanshan Huang, Yong Wang, Zhiwen Jiang, Zhuohang Liu, Chenran Wang, Rong Ji, Yiwen Yuan, Xueyu Mao, Kaicheng Yang, Huicong Niu, Yanqin Gao, Jing Zhao   +12 more
wiley   +1 more source

Differential Modulation of Reinforcement Learning by D2 Dopamine and NMDA Glutamate Receptor Antagonism [PDF]

, 2014
Gerhard Jocham, Tilmann A. Klein, Markus Ullsperger   +2 more
openalex   +1 more source

Astrocytic PCBP1 Suppresses Ferroptosis to Restore Glutamatergic Homeostasis and Mitigate Stress‐Induced Depression in Male Mice

Advanced Science, EarlyView.
This study demonstrates that polyC‐RNA‐binding protein 1 (PCBP1) in ventral hippocampal astrocytes modulates depressive‐like behaviors by regulating glutathione peroxidase 4‐mediated ferroptosis and synaptic glutamatergic transmission. PCBP1 overexpression intervention in the chronic unpredictable mild stress model rescues behavioral deficits ...
Jinyu Zhang, Binbin Zhao, Min Jia, Yan Zhao, Ye Lu, Wenyu Xi, Ziyu Zhu, Xiaojuan Gong, Qingyan Ma, Yuan Gao, Yijie Guo, Pan Li, Feng Zhu, Shuguang Wei, Xiancang Ma, Yunpeng Wang   +15 more
wiley   +1 more source

Metabotropic glutamate receptor 5 within nucleus accumbens shell modulates environment-elicited cocaine conditioning expression

, 2013
Arlene Martínez-Rivera, Enrique Rodríguez-Borrero, María Matías-Alemán, Alexandra Montalvo-Acevedo, Kathleen Guerrero-Figuereo, Liz J. Febo-Rodríguez, Amarilys Morales-Rivera, Carmen S. Maldonado-Vlaar   +7 more
openalex   +2 more sources

Cocaine use disorder: A look at metabotropic glutamate receptors and glutamate transporters

, 2021
Ewa Niedzielska, Lucyna Pomierny-Chamioło, Michał Andres, Maria Walczak, Lori A. Knackstedt, Małgorzata Filip, Edmund Przegaliński   +6 more
openalex   +2 more sources

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

Advanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang, Yuxin Yang, William Martin, Kingsten Lin, Zixu Wang, Cheng‐Chang Lu, Weiwen Jiang, Ruth Nussinov, Joseph Loscalzo, Qiang Guan, Feixiong Cheng   +10 more
wiley   +1 more source

The Ca²⁺/Cl⁻ dependent L‐[³H]glutamate binding: a new receptor or a particular transport process? [PDF]

, 1984
Jean‐Philippe Pin, Joël Bockaert, M. Recasesn   +2 more
openalex   +1 more source