Results 151 to 160 of about 2,638,315 (394)

LTP requires a reserve pool of glutamate receptors independent of subunit type

Nature, 2012
Long-term potentiation (LTP) of synaptic transmission is thought to be an important cellular mechanism underlying memory formation. A widely accepted model posits that LTP requires the cytoplasmic carboxyl tail (C-tail) of the AMPA (α-amino-3-hydroxy-5 ...
Adam J. Granger, Y. Shi, Wei Lu, Manuel Cerpas, R. Nicoll   +4 more
semanticscholar   +1 more source

RFWD3 Reprograms Nucleotide Metabolism Through PHGDH to Induce Chemoresistance In Osteosarcoma

Advanced Science, EarlyView.
RFWD3 is identified as a key regulator of cisplatin (DDP) sensitivity in osteosarcoma using a genome‐wide CRISPR screen. RFWD3 promotes PHGDH ubiquitination, enhancing NAD+‐mediated nucleotide biosynthesis. Knocking out RFWD3 sensitized osteosarcoma cells to DDP.
Wenchao Zhang, Chi Yin, Lin Qi, Zhongyue Liu, Ruiling Xu, Chao Tu, Zhihong Li   +6 more
wiley   +1 more source

Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform

Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
Combining ligand‐based and structure‐based methodologies, the applied virtual screening approach identified a collection of sulfonamides targeting the human carbonic anhydrase (hCA) VA isoform. 2‐(3,4‐Dihydro‐2H‐quinolin‐1‐yl)‐N‐(4‐sulfamoylphenyl)acetamide was identified as a potent and selective lead compound as a candidate for further exploitation ...
Laura De Luca, Andrea Angeli, Federico Ricci, Claudiu T. Supuran, Rosaria Gitto   +4 more
wiley   +1 more source

Structural Diversity of Mitochondria in the Neuromuscular System across Development Revealed by 3D Electron Microscopy

Advanced Science, EarlyView.
Mitochondria across the entire neuromuscular system have been comprehensively reconstructed at different developmental stages using 3D electron microscopy. Fundamental structural principles related to synaptic function are preserved across development, and these morphologies are adapted to ensure effective neural circuit function.
J. Alexander Bae, Myung‐kyu Choi, Soungyub Ahn, Gwanho Ko, Daniel T. Choe, Hyunsoo Yim, Ken C. Nguyen, Jinseop S. Kim, David H. Hall, Junho Lee   +9 more
wiley   +1 more source

SAR exploration of the non‐imidazole histamine H3 receptor ligand ZEL‐H16 reveals potent inverse agonism

Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023
ZEL‐H16 (1) has been disclosed to be a high‐affinity non‐imidazole H3R (partial) agonist. However, it was found that 1 acts as an inverse agonist for Gαi in various assays. Concise structure–activity relationship studies, molecular pharmacology, and docking were used to shed more light on the properties of 1.
Gábor Wágner, Tamara A. M. Mocking, Xiaoyuan Ma, Inna Slynko, Daniel Da Costa Pereira, Robin Breeuwer, Niek J. N. Rood, Cas van der Horst, Henry F. Vischer, Chris de Graaf, Iwan J. P. de Esch, Maikel Wijtmans, Rob Leurs   +12 more
wiley   +1 more source

Metabotropic glutamate receptors mediate excitatory transmission in the nucleus of the solitary tract [PDF]

, 1992
SR Glaum, RJ Miller
openalex   +1 more source

Berberine is a Novel Mitochondrial Calcium Uniporter Inhibitor that Disrupts MCU‐EMRE Assembly

Advanced Science, EarlyView.
Berberine, a safe and FDA‐approved drug, is identified as a novel mitochondrial calcium uniporter (MCU) inhibitor. By disrupting MCU‐EMRE interaction, Berberine prevents mitochondrial calcium overload and protects against ischemia/reperfusion injury, offering a promising therapeutic strategy for diseases linked to mitochondrial calcium dysregulation ...
Haixin Zhao, Siqi Chen, Nian Cao, Wenjun Wu, Guangqin Liu, Jun Gao, Jiayi Chen, Ting Li, Dingyi Lu, Lingmin Zeng, Haizhen Zhu, Weina Zhang, Qing Xia, Teng Li, Tao Zhou, Xue‐Min Zhang, Ai‐Ling Li, Xin Pan   +17 more
wiley   +1 more source

Immunostimulatory Hydrogel with Synergistic Blockage of Glutamine Metabolism and Chemodynamic Therapy for Postoperative Management of Glioblastoma

Advanced Science, EarlyView.
To address the challenge of postoperative recurrence, Combo Gel, a peptide‐based hydrogel that integrates glutamine metabolism modulation with chemodynamic therapy (CDT) is engineered. This innovative system, containing CB‐839 and copper peptide nanoparticles (Cu‐His NPs), enhances CDT's efficacy and promotes immunogenic cell death, thereby ...
Yiran Guo, Tianhe Jiang, Sen Liang, Anhe Wang, Jieling Li, Yi Jia, Qi Li, Jian Yin, Shuo Bai, Junbai Li   +9 more
wiley   +1 more source

A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis

Advanced Science, EarlyView.
The dynamic interplay between central respiratory chemoreceptors and the respiratory central pattern generator is essential for maintaining stable respiratory rhythm and patterns, particularly during sleep. This study offers novel insights into the anatomical, molecular, and functional characteristics of a medullary network involving the nucleus ...
Tianjiao Deng, Xinyi Jing, Liuqi Shao, Yakun Wang, Congrui Fu, Hongxiao Yu, Xiaoyi Wang, Xue Zhao, Fanrao Kong, Yake Ji, Xiaochen Tian, Wei He, Shangyu Bi, Luo Shi, Hanqiao Wang, Fang Yuan, Sheng Wang   +16 more
wiley   +1 more source

Glutamate receptors and schizophrenia [PDF]

Journal of Psychopharmacology, 1987
B.S. Meldrum, R.W. Kerwin
openaire   +3 more sources