Results 171 to 180 of about 2,596,775 (326)

Cross-signaling in metabotropic glutamate 2 and serotonin 2A receptor heteromers in mammalian cells

, 2016
Lia Baki, Miguel Fribourg, Jason Younkin, José M. Eltit, José L. Moreno, Chang Gyu Park, Zhanna Vysotskaya, Adishesh K. Narahari, Stuart C. Sealfon, Javier González‐Maeso, Diomedes E. Logothetis   +10 more
openalex   +2 more sources

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Delta-type glutamate receptors are ligand-gated ion channels. [PDF]

Nature
Wang H, Ahmed F, Khau J, Mondal AK, Twomey EC.   +4 more
europepmc   +1 more source

Glutamate receptors and schizophrenia [PDF]

Journal of Psychopharmacology, 1987
B S, Meldrum, R W, Kerwin
openaire   +2 more sources

Sustained activation of renal N-methyl-d-aspartate receptors decreases vitamin D synthesis: a possible role for glutamate on the onset of secondary HPT

, 2010
Eva Parisi, Milica Božić, Mercè Ibarz, Sara Panizo, Petya Valcheva, Blai Coll, Elvira Fernández, José Manuel Valdivielso   +7 more
openalex   +2 more sources

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Architecture, dynamics and biogenesis of GluA3 AMPA glutamate receptors. [PDF]

Nature
Pokharna A, Stockwell I, Ivica J, Singh B, Schwab J, Vega-Gutiérrez C, Herguedas B, Cais O, Krieger JM, Greger IH.   +9 more
europepmc   +1 more source

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

Pharmacological Reviews, 2010
S. Traynelis, L. Wollmuth, C. McBain, F. Menniti, Katie M Vance, Kevin K Ogden, K. Hansen, Hongjie Yuan, S. J. Myers, R. Dingledine   +9 more
semanticscholar   +1 more source

Localization and Expression of Group I Metabotropic Glutamate Receptors in the Mouse Striatum, Globus Pallidus, and Subthalamic Nucleus: Regulatory Effects of MPTP Treatment and Constitutive Homer Deletion [PDF]

, 2007
Masaaki Kuwajima, Marlin H. Dehoff, Teiichi Furuichi, Paul Worley, Randy A. Hall, Yoland Smith   +5 more
openalex   +1 more source

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

Advanced Science, EarlyView.
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Sunny H. Kim, Arshad J. Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B. Katz, Yong Zhang   +8 more
wiley   +1 more source