Results 241 to 250 of about 65,627 (289)

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Mechanistic insights into TTLL11 polyglutamylase-mediated primary tubulin chain elongation. [PDF]

Sci Adv
Campbell J, Vosahlikova M, Ismail S, Volnikova M, Motlova L, Kudlacova J, Ustinova K, Snajdr I, Novakova Z, Basta M, Gutsche I, Moutin MJ, Desfosses A, Barinka C.   +13 more
europepmc   +1 more source

Systematic Metabolic Engineering and Model‐Guided Optimization for High‐Level Production of L‐Theanine from Xylose in Escherichia coli

Advanced Science, EarlyView.
This study is pioneering in constructing the shortest known synthetic pathway for L‐theanine production from xylose within E coli. Through comprehensive metabolic engineering strategies, our engineered strain achieved the highest reported L‐theanine titer from xylose, with a titer of 95.42 g/L, and a yield of 0.55 g/g.
Haolin Han, Boyuan Xue, Guangqi Shan, Meng Meng, Shaojie Wang, Haijia Su   +5 more
wiley   +1 more source

In Silico Description of the Direct Inhibition Mechanism of Endothelial Lipase by ANGPTL3. [PDF]

Int J Mol Sci
Montavoci L, Ben Mariem O, Saporiti S, Laurenzi T, Palazzolo L, Ossoli AF, Guerrini U, Calabresi L, Eberini I.   +8 more
europepmc   +1 more source

Metarhizium anisopliaeMitigates the Phytotoxicity of Lead and Nanoplastics on Rice by Modifying Physiological, Transcriptomic, Metabolomic Activities, and Soil Microbiome

Advanced Science, EarlyView.
Metarhizium anisopliae alleviates the phytotoxic effects of polyethylene nanoplastics (NP) and lead (Pb) in rice by decreasing Pb uptake, restoring antioxidant and hormonal equilibrium, and promoting growth. Additionally, the fungus modifies the rhizosphere microbiota, enhancing both contaminant tolerance and plant growth, thereby effectively ...
Jing Peng, Qi Yan, Muhammad Umair Hassan, Muhammad Imran, Fasih Ullah Haider, Jianfeng Liang, Xingmin Wang, Shaukat Ali   +7 more
wiley   +1 more source

Moderately thermostable GH1 β-glucosidases from hyperacidophilic archaeon Cuniculiplasma divulgatum S5. [PDF]

FEMS Microbiol Ecol
Khusnutdinova AN, Tran H, Devlekar S, Distaso MA, Kublanov IV, Skarina T, Stogios P, Savchenko A, Ferrer M, Golyshina OV, Yakunin AF, Golyshin PN.   +11 more
europepmc   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Unveiling Fermentation Effects on the Functional Composition of Taiwanese Native Teas. [PDF]

Molecules
Hung WT, Kuo CC, Lu JJ, Yang FS, Cheng YL, Sung YJ, Chiou CS, Huang HH, Su TC, Tsai HT, Cheng KC.   +10 more
europepmc   +1 more source

Multiplex and multimodal mapping of variant effects in secreted proteins via MultiSTEP. [PDF]

Nat Struct Mol Biol
Popp NA, Powell RL, Wheelock MK, Holmes KJ, Zapp BD, Sheldon KM, Fletcher SN, Wu X, Fayer S, Rubin AF, Lannert KW, Chang AT, Sheehan JP, Johnsen JM, Fowler DM.   +14 more
europepmc   +1 more source

Transport of metformin metabolites by guanidinium exporters of the small multidrug resistance family. [PDF]

J Gen Physiol
Lucero RM, Demirer K, Yeh TJ, Stockbridge RB.   +3 more
europepmc   +1 more source