Results 71 to 80 of about 155,970 (214)

A role for oxytocin in the etiology and treatment of schizophrenia

Frontiers in Endocrinology, 2015
Schizophrenia is a chronic debilitating neuropsychiatric disorder estimated to affect 51 million people worldwide. Several symptom domains characterize schizophrenia, including negative symptoms, such as social withdrawal and anhedonia, cognitive ...
Megan Elizabeth Rich, Heather Kingsley Caldwell   +1 more
doaj   +1 more source

Multiple Routes for Glutamate Receptor Trafficking: Surface Diffusion and Membrane Traffic Cooperate to Bring Receptors to Synapses [PDF]

Science's STKE (electronic resource) : signal transduction knowledge environment 327 (21/03/2006) 13, 2007
Trafficking of glutamate receptors into and out of synapses is critically involved in the plasticity of excitatory synaptic transmission. Endocytosis and exocytosis of receptors have initially been thought to account alone for this trafficking. However, membrane proteins also traffic through surface lateral diffusion in the plasma membrane. We describe
arxiv  

Surface grafting of poly(L-glutamates). 2. Helix orientation

, 2001
In this paper the average helix orientation of surface-grafted poly(γ-benzyl l-glutamate) (PBLG), poly(γ-methyl l-glutamate) (PMLG), and poly(γ-methyl l-glutamate)-co-(γ-n-stearyl l-glutamate) (PMLGSLG 70/30) was investigated by means of FT-IR ...
R. H. Wieringa, E. Siesling, P. Werkman, H. Angerman, E. Vorenkamp, A. Schouten   +5 more
semanticscholar   +1 more source

Maillard Type Reaction for Electroless Copper Plating onto Ceramic Nanoparticles

Advanced Engineering Materials, EarlyView.
This work presents the manufacturing of copper‐plated ceramic nanoparticles in an environmentally friendly way. Supported by organic functionalizations with pectin an electroless plating step can be performed. Sustainable reagents like xylose, and several amino acids are used for the reduction process.
Lukas Mielewczyk, Julia Grothe, Stefan Kaskel, Heinrich von Lintel, Katja Eichmann, Katrin Jahns, Avinash Hariharan, Abdelrahman Elsayed, Ulrich Krupp   +8 more
wiley   +1 more source

A study of genetic heterogeneity in autism spectrum disorders based on plasma proteomic and metabolomic analysis: multiomics study of autism heterogeneity

MedComm, 2023
Genetic heterogeneity poses a challenge to research and clinical translation of autism spectrum disorder (ASD). In this study, we conducted a plasma proteomic and metabolomic study of children with ASD with and without risk genes (de novo mutation) and ...
Xiaoxiao Tang, Chengyun Feng, Yuxi Zhao, Huajie Zhang, Yan Gao, Xueshan Cao, Qi Hong, Jing Lin, Hongbin Zhuang, Yuying Feng, Hanghang Wang, Liming Shen   +11 more
doaj   +1 more source

3D In Vitro Glioma‐Neuron‐Astrocyte Biomimetic Composites Recapitulate Key Molecular Mechanisms Linked to Glioblastoma Multiforme Pathophysiology

Advanced Functional Materials, EarlyView.
Glioblastoma multiforme is the most devastating and incurable brain tumor. To better study this disease, a 3D model is developed using a hyaluronic acid‐based hydrogel combined with a multicellular approach. This model recapitulates in vivo brain stiffness, cell‐extracellular matrix and cell‐cell interactions and the tumor's hijacking function with the
Mateo S. Andrade Mier, Esra Türker, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Panthipa Suwannakot, Benedikt Gantert, Abhinav Singh, Vanessa Moessler, Annemarie Sodmann, Nicoletta Murenu, Joachim Schenk, Natascha Schaefer, Torsten Blunk, Aldo R. Boccaccini, Tessa C. Lühmann, Jörg Tessmar, Jeremy M. Crook, Eva Tomaskovic‐Crook, Paul D. Dalton, Gregor Lang, Robert Blum, Reiner Strick, Silvia Budday, Katrin G. Heinze, Carmen Villmann   +26 more
wiley   +1 more source

H2O2‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, EarlyView.
H2O2‐generating nanoplatforms can exploit tumor redox imbalance for O2 and toxic reactive oxygen species generation, leading to hypoxia reversal, and apoptosis of cancer cells, respectively. This review highlights the mechanisms of these nanoplatforms, including exogenous H₂O₂ delivery, endogenous amplification, and metal peroxides, which leads to ...
Kiyan Musaie, Samin Abbaszadeh, Kik Marais, Vahideh Nosrati‐Siahmazgi, Saman Rezaei, Bo Xiao, Kamal Dua, Hélder A. Santos, Mohammad‐Ali Shahbazi   +8 more
wiley   +1 more source

Enzymatic identification and functional sites study of a novel cold-active cellulase (MkCel5) from Microbacterium kitamiensea

Biotechnology & Biotechnological Equipment, 2019
A strain of Microbacterium kitamiense capable of decomposing cellulose was obtained from the soil of Shigatse region in Tibet. Low temperature and cellulase gene MkCel5 was cloned and sequenced.
Yuanyuan Li, Zhiyuan Wang, Yating Zhou, Guoping Zhu, Ling Lin   +4 more
doaj   +1 more source

High‐Throughput Microfluidic‐Mediated Assembly of Layer‐By‐Layer Nanoparticles

Advanced Functional Materials, EarlyView.
The layer‐by‐layer (LbL) assembly of polymer films on nanoparticle (NP) surfaces is a promising technique for targeted drug delivery. Despite its success in preclinical mouse models, a current good manufacturing practices (cGMP) compliant, clinical‐scale production method has been lacking.
Ivan S. Pires, Ezra Gordon, Heikyung Suh, Darrell J. Irvine, Paula T. Hammond   +4 more
wiley   +1 more source

QM/MM study of the stereospecific proton exchange of glutathiohydroxyacetone by glyoxalase I

Results in Chemistry, 2019
We have performed quantum mechanics (QM), molecular mechanics (MM) and hybrid QM/MM calculations to study the stereospecific proton exchange of glutathiohydroxyacetone (HOC-SG) by glyoxalase I (GlxI). We did the QM/MM calculations with a large QM system (
Sonia Jafari, Ulf Ryde, Mehdi Irani
doaj