Results 1 to 10 of about 42,820 (244)

Neurological manifestations of glutamic acid decarboxylase autoimmunity in Indian patients [PDF]

Annals of Indian Academy of Neurology, 2023
Objective: To study the neurological manifestations of glutamic acid decarboxylase (GAD 65) autoimmunity in Indian patients. Methods: Retrospective study conducted in a tertiary care referral hospital in South India.
Meena Thevarkalam, Sudheeran Kannoth, Vivek Nambiar, Siby Gopinath, Annamma Mathai, Anandkumar Anandakuttan, Sajitha Krishnan, Renjitha Bhaskaran   +7 more
doaj   +2 more sources

Wolbachia infection confers post-translational modification of glutamic acid decarboxylase and other proteins in D. melanogaster [PDF]

Microbiology Spectrum
Wolbachia pipientis is a ubiquitous intracellular bacterium that is known for its manipulation of reproduction in arthropod hosts. Wolbachia has also been shown to colonize virtually all somatic tissues, including the brain, but little is known about the
Sarah M. Boothman, Sarah Preston, Jonathan Minden   +2 more
doaj   +2 more sources

Case report: Approaches to treatment-refractory and super-refractory glutamic acid decarboxylase antibody-spectrum disorders [PDF]

Frontiers in Immunology, 2023
BackgroundGlutamic acid decarboxylase antibody-spectrum disorders (GAD-SDs) include a group of autoimmune neurological diseases associated with neuronal excitability, most noticeably stiff person syndrome. Immune modulators are the mainstay of treatment,
Ravi Rajmohan, Shivali Baveja, Dai Nguyen, Eshita Shah, Michael Sy, Sanaz Attaripour, David Swope   +6 more
doaj   +2 more sources

Oculomotor Abnormalities in Anti-Glutamic Acid Decarboxylase-Positive Stiff Person Syndrome [PDF]

Neurology International
Background: Antibodies to glutamic acid decarboxylase (anti-GAD) can give rise to stiff person syndrome (SPS), an infrequent autoimmune condition of the central nervous system marked by fluctuating muscular rigidity and stimulus-evoked spasms ...
Pavol Skacik, Jaroslav Petrisin, Kristian Sveda, Monika Turcanova-Koprusakova, Milan Grofik, Stefan Sivak, Egon Kurca   +6 more
doaj   +2 more sources

Autoimmune meningoencephalitis associated with anti‐glutamic acid decarboxylase antibody following COVID‐19 infection: A case report [PDF]

Clinical Case Reports, 2022
Anti‐glutamic acid decarboxylase (Anti‐GAD) are associated with various neurologic condition; but no meningitis has been reported with it, so far. Evidence demonstrates the associated of autoimmune meningoencephalitis with COVID‐19 infection.
Mehri Salari, Bahareh Zaker Harofteh, Masoud Etemadifar   +2 more
doaj   +2 more sources

Anti-glutamic acid decarboxylase 65: Related stiff person syndrome – A report of two cases and literature review [PDF]

SAGE Open Medical Case Reports
Stiff person syndrome is a rare neurological disorder characterized by muscular rigidity, painful spasms, and gait abnormalities. The diagnosis is primarily clinical and often requires a high index of suspicion.
Ena Elizabeth L. Naoe, Redentor R. Durano, Ranhel C. De Roxas-Bernardino, Gerard Saranza   +3 more
doaj   +2 more sources

Glutamic Acid Decarboxylase Autoantibodies-Related Encephalitis

Pediatric Neurology Briefs, 2011
Researchers at University Hospital of Geneva, Switzerland, report a case of glutamic acid decarboxylase autoantibodies (GADA)-related encephalitis in a 6-year-old girl and review the literature.
J Gordon Millichap
doaj   +3 more sources

Reversible Sterilization of Channel Catfish via Overexpression of Glutamic Acid Decarboxylase Gene [PDF]

Animals
The confinement of transgenic fish is essential to prevent their escape and reproduction in natural ecosystems. Reversible transgenic sterilization is a promising approach to control the reproduction of transgenic fish.
Zhi Ye, Ahmed Elaswad, Baofeng Su, Ahmed Alsaqufi, Mei Shang, William S. Bugg, Guyu Qin, David Drescher, Hanbo Li, Zhenkui Qin, Ramjie Odin, Nonkonzo Makhubu, Nermeen Abass, Sheng Dong, Rex Dunham   +14 more
doaj   +2 more sources

Glutamic acid decarboxylase antibody-spectrum disorders and type 1 diabetes mellitus in a patient following allogenic hematopoietic cell transplantation with review of literature [PDF]

Endocrine Journal
Glutamic acid decarboxylase (GAD) is an enzyme that catalyzes the conversion of glutamic acid into γ-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system (CNS).
Shinichiro Sano, Taemi Ogura, Takayuki Takachi, Yuki Murai, Yasuko Fujisawa, Tsutomu Ogata, Kenichiro Watanabe, Masaki Yoshimura   +7 more
doaj   +2 more sources

α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody–positive individuals [PDF]

The Journal of Clinical Investigation, 2022
BACKGROUND Multiple islet autoantibodies (AAbs) predict the development of type 1 diabetes (T1D) and hyperglycemia within 10 years. By contrast, T1D develops in only approximately 15% of individuals who are positive for single AAbs (generally against ...
Nicolai M. Doliba, Andrea V. Rozo, Jeffrey Roman, Wei Qin, Daniel Traum, Long Gao, Jinping Liu, Elisabetta Manduchi, Chengyang Liu, Maria L. Golson, Golnaz Vahedi, Ali Naji, Franz M. Matschinsky, Mark A. Atkinson, Alvin C. Powers, Marcela Brissova, Klaus H. Kaestner, Doris A. Stoffers, for the HPAP Consortium   +18 more
doaj   +2 more sources