Results 31 to 40 of about 43,118 (240)

A unique profile of insulin antibody titer in islet‐transplanted patients

Journal of Diabetes Investigation, 2022
Insulin antibodies (IAs) can cause glycemic variability. Islet transplantation (ITx) is a treatment for insulin‐deficient diabetes that aims to establish on‐target glycemic control in the absence of hypoglycemia.
Yamato Keidai, Junji Fujikura, Toshihiro Nakamura, Takayuki Anazawa, Ryo Ito, Masahito Ogura, Etsuro Hatano, Nobuya Inagaki   +7 more
doaj   +1 more source

Gad65 is recognized by t-cells, but not by antibodies from nod-mice [PDF]

, 1994
Since the 64kDa-protein glutamic acid decarboxylase (GAD) is one of the major autoantigens in T-cell mediated Type 1 diabetes, its relevance as a T-cell antigen needs to be clarified. After isolation of splenic T-cells from non-obese diabetic (NOD) mice,
Alzari PM, Atkinson MA, Baekkeskov S, Bieg S, Christgau S, Christie MR, Diaz JL, Eisenbarth GS, Hackett CJ, Honeyman MC, J. Seissler, Jennings PA, L. Herberg, Leiter EH, Lie W, Mauch L, Miller LP, Ohneda A, Peters PJ, Roep BO, Roep BO, S. Bieg, Seissler J, Seissler J, Solimena M, Solimena M, Velloso LA, W. A. Scherbaum, W. Northemann   +28 more
core   +1 more source

Different interaction of onset age and duration of type 1 diabetes on the dynamics of autoantibodies to insulinoma‐associated antigen‐2 and zinc transporter 8

Journal of Diabetes Investigation, 2021
Aims/Introduction This study aimed to investigate the dynamics associated with autoantibodies to insulinoma‐associated antigen‐2 (IA‐2A) and zinc transporter 8 (ZnT8A) relating to the onset age and disease duration in patients with type 1 diabetes ...
Eiji Kawasaki, Yoichi Oikawa, Akira Okada, Norio Kanatsuna, Tomoyuki Kawamura, Tadashi Kikuchi, Jungo Terasaki, Junnosuke Miura, Yoshihisa Itoh, Toshiaki Hanafusa   +9 more
doaj   +1 more source

Association between Antibodies to the MR 67,000 Isoform of Glutamate Decarboxylase (GAD) and Type 1 (Insulin-Dependent) Diabetes Mellitus with Coexisting Autoimmune Polyendocrine Syndrome Type II [PDF]

, 1994
By using an immunoprecipitation assay, we analysed reactivity of autoantibodies to human recombinant GAD65 and GAD67 in sera from patients with autoimmune polyendocrine syndrome Type II (APS II) with and without Type 1 (insulin-dependent) diabetes ...
Baekkeskov S., Banga J. P., Bernhard O. Boehm, Betterle C. F., Bjork E., Bottazzo G. F, Bottazzo G. F., Christie M. R., Genovese S., Hagopan W. A., Jochen Seissler, Karlsen A. E., Kawasaki E., Kim J., Ludwig Mauch, Mauch L., Muir A., Nadja Yassin, Richter W., Riley W. J., Sabine Bieg, Scherbaum W. A, Scherbaum W. A., Schmidli R TS, Seissler J., Solimena M., Tarn A. C., Ujihara N., Velloso L. A., Wagner R., Wagner R., Werner A. Scherbaum, Wolfgang Northemann   +32 more
core   +1 more source

IMMUNOLOGIC PREVENTION OF IDDM BY ORAL ADMINISTRATION OF GLUTAMIC ACID DECARBOXYLASE [PDF]

Acta Medica Iranica, 1999
 We have Investigated the preventive effects of oral administration of isolated E.coli ghttam'tc acid decarboxylase (GAD) in animal models. Based on our results, the blood glucose levels were reduced by oral administration of GAD to rats 14
L. Yazdchi Mari, Sh. Rajieii. R. Yazdanparast   +1 more
doaj   +2 more sources

Evidence for a GABAergic system in rodent and human testis: Local GABA production and GABA receptors [PDF]

, 2003
The major neurotransmitter of the central nervous system, gamma-aminobutyric acid (GABA), exerts its actions through GABA(A), GABA(B) and GABA(C) receptors.
Calandra, Ricardo S., Doepner, Richard F. G., Frungieri, Monica B., Gamel-Didelon, Katia, Geigerseder, Christof, Kohn, Frank M., Mayerhofer, Artur, Thalhammer, Andrea   +7 more
core   +2 more sources

Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight [PDF]

, 2019
FKBP5 (FKBP51) is a glucocorticoid receptor (GR) binding protein, which acts as a co-chaperone of heat shock protein 90 (HSP90) and negatively regulates GR.
Deng, Ran, Dou, Longyu, Liang, Tiebing, Liu, Ming, Qiu, Bin, Ren, Wei, Shou, Weinian, Stewart, Robert B., Wang, Chao, Wang, Jun, Williams, Kent E., Xie, Zhongwen, Xu, Yuxue, Yong, Weidong, Zhao, Zhenwen   +14 more
core   +1 more source

AUTOANTIBODIES TO GLUTAMIC ACID DECARBOXYLASE AS A PATHOGENETIC MARKER OF TYPE I DIABETES MELLITUS

Медицинская иммунология, 2014
. A new method of enzyme-linked immunosorbent assay (in solid-phase ELISA format) has been developed to determine concentrations of autoantibodies to glutamic acid decarboxylase, as well as an evidencebased methodology is proposed for its medical ...
N. V. Piven, L. N. Lukhverchyk, A. I. Burakovsky, N. V. Polegenkaya, M. V. Karpovich   +4 more
doaj   +1 more source

Cytoplasmic islet cell antibodies recognize distinct islet antigens in IDDM but not in stiff man syndrome [PDF]

, 1993
Cytoplasmic islet cell antibodies are well-established predictive markers of IDDM. Although target molecules of ICA have been suggested to be gangliosides, human monoclonal ICA of the immunoglobulin G class (MICA 1-6) produced from a patient with newly ...
Meinck, Hans-Michael, Northemann, Wolfgang, Richter, Wiltrud, Scherbaum, Werner A., Seißler, Jochen, Wolfahrt, S.   +5 more
core   +1 more source

Screening of endocrine organ-specific humoral autoimmunity in 47,XXY Klinefelter's syndrome reveals a significant increase in diabetes-specific immunoreactivity in comparison with healthy control men. [PDF]

, 2015
The aim of this study was to evaluate the frequency of humoral endocrine organ-specific autoimmunity in 47,XXY Klinefelter’s syndrome (KS) by investigating the autoantibody profile specific to type 1 diabetes (T1DM), Addison’s disease (AD), Hashimoto ...
ANZUINI, Antonella, GIANFRILLI, DANIELE, GRANATO, SIMONA, LENZI, Andrea, PANIMOLLE, FRANCESCA, RADICIONI, Antonio, Semeraro, A, TIBERTI, Claudio   +7 more
core   +1 more source