Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus [PDF]
, 2019 The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented.
Abba, Martín Carlos +11 more
core +2 more sources
A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation
Angewandte Chemie, EarlyView.The fatal mushroom toxin l‐(+)‐muscarine is one of the most prominent natural products. We elucidated its biosynthetic origin in the sweating mushroom Collybia rivulosa based on incorporation of stable isotope‐labeled compounds and extensive mass spectrometric analyses.
Sebastian Dörner +4 more
wiley +2 more sources
Stiff-Person Syndrome: Case Series [PDF]
Journal of Movement Disorders, 2014 Stiff-person syndrome (SPS) is a rare disorder, characterized by progressive fluctuating muscular rigidity and spasms. Glutamic acid decarboxylase (GAD) antibody is primarily involved in the pathogenesis of SPS and SPS is strongly associated with other ...
Yu Jin Jung +4 more
doaj +1 more source
Change of Indices of the Amino Acid Composition of Rats' Hearts at Artificial Hypobiosis [PDF]
, 2019 A series of unsolved questions in such sciences as: medicine, veterinary, biology still exist in the modern world. One of them is a search for new promising ways of anaesthetization, at which it would be unnecessary to use apparatuses as an “artificial ...
Umanska, A. (Anna)
core +3 more sources
Downbeat nystagmus: aetiology and comorbidity in 117 patients [PDF]
, 2008 Objectives: Downbeat nystagmus (DBN) is the most common form of acquired involuntary ocular oscillation overriding fixation. According to previous studies, the cause of DBN is unsolved in up to 44% of cases.
Brandt, Thomas +3 more
core +1 more source
The yhiM gene codes for an inner membrane protein involved in GABA export in Escherichia coli [PDF]
, 2017 In order to survive the exposure to acid pH, Escherichia coli activates molecular circuits leading from acid tolerance to extreme acid resistance (AR). The activation of the different circuits involves several global and specific regulators affecting the
Angela Tramonti +4 more
core +2 more sources
Neurological disorders associated with glutamic acid decarboxylase antibodies: a Brazilian series
Arquivos de Neuro-Psiquiatria, 2012 Neurological disorders associated with glutamic acid decarboxylase (GAD) antibodies are rare pleomorphic diseases of uncertain cause, of which stiff-person syndrome (SPS) is the best-known.
Maurício Fernandes +7 more
doaj +1 more source
Oxygen, 2023 Flooding induces low-oxygen stress, which reduces plant growth. The activity of the γ-aminobutyric acid (GABA) shunt is crucial for plant stress adaptation, in which it acts by changing cytosolic pH, limiting reactive oxygen species production ...
Setsuko Komatsu +2 more
doaj +1 more source
Glutamic acid decarboxylase antibodies in screening for autoimmune diabetes: influence of comorbidity, age, and sex on specificity and threshold values [PDF]
, 1999 This study demonstrates that age- and sex-nondefined populations can be used for definition of reference values for glutamic acid decarboxylase (GAD65) antibodies and that comorbidity involving tissues that express GAD needs not be taken into account ...
Aanstoot, H-J. (Henk-Jan) +8 more
core +3 more sources
A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai +5 more
wiley +1 more source