Results 91 to 100 of about 42,820 (244)

Anti-glutamic acid decarboxylase antibodies-associated cerebellar ataxia: A treatable ataxia

Annals of Movement Disorders
BACKGROUND: Anti-glutamate decarboxylase 65 antibody-associated cerebellar ataxia (anti-GAD65Ab-associated CA) is the most widely studied immune-mediated CA.
Rohan Mahale, Sandeep M, Anita Mahadevan, Nitish Kamble, Vikram Holla, Ravindranadh Mundlamuri, Seena Vengalil, Netravathi M, Atchayaram Nalini, Pramod Kumar Pal, Ravi Yadav   +10 more
doaj   +1 more source

T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. [PDF]

, 1994
Limited regions of amino acid sequence similarity frequently occur between microbial antigens and host proteins. It has been widely anticipated that during infection such sequence similarities could induce cross-reactive T cell responses, thereby ...
Kaufman, DL, Lehmann, PV, Tian, J
core  

GABAergic neurons regulate lateral ventricular development via transcription factor Pax5 [PDF]

, 2013
Postmortem studies have revealed a downregulation of the transcription factor Pax5 in GABAergic neurons in bipolar disorder, a neurodevelopmental disorder, raising the question whether Pax5 in GABAergic neurons has a role in normal brain development.
Asada, Benes, Bouchard, Ciani, Condie, Edmiston, Estivill-Torrus, Funahashi, Homanics, Horcher, Kempton, Louvi, Ma, Machon, Makiyama, Matsumoto, Meduri, Miller, Muyrers, Novak, Oh, Pfeffer, Rosa, Rowitch, Schwarz, Srinivas, Tamamaki, Tashiro, Tashiro, Thomas, Urbanek, Wojcik, Wurst, Ye, Zygourakis   +34 more
core   +2 more sources

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders

MedComm, Volume 7, Issue 4, April 2026.
CAR‐T cell therapy in systemic rheumatic diseases and autoimmune disorders. (This figure was created using BioRender.com.) ABSTRACT Chimeric antigen receptor T (CAR‐T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs).
Zhidan Fan, Li Zhang, Haiguo Yu
wiley   +1 more source

Investigating Diabetes-associated Autoantibodies and Their Relationship to Clinical Characteristics in Children Diagnosed With Type 1 Diabetes [PDF]

Journal of Pediatrics Review
Background: Type 1 diabetes mellitus (T1DM) is an autoimmune disorder characterized by the destruction of insulin-producing beta cells in the pancreas, leading to insulin deficiency.
Niloofaralsadat Motamedi, Daniel Zamanfar, Fatemeh Rostamian Motlagh, Jamshid Yazdani Charati   +3 more
doaj  

Hippocampus and Insula Are Targets in Epileptic Patients With Glutamic Acid Decarboxylase Antibodies

Frontiers in Neurology, 2019
Background: Antibodies to glutamic acid decarboxylase (GAD ab) have been found in patients with limbic encephalitis (LE) and chronic pharmacoresistant focal epilepsy (FE).
Mercè Falip, Laura Rodriguez-Bel, Sara Castañer, Jacint Sala-Padró, Júlia Miro, Sónia Jaraba, Carlos Casasnovas, Francisco Morandeira, Javier Berdejo, Mar Carreño   +9 more
doaj   +1 more source

A novel bacterial l-arginine sensor controlling c-di-GMP levels in Pseudomonas aeruginosa [PDF]

, 2018
Nutrients such as amino acids play key roles in shaping the metabolism of microorganisms in natural environments and in host–pathogen interactions.
Cutruzzolà, F., Giardina, G., Janson, G., Leoni, L., Mantoni, F., Paiardini, A., Paone, A., Rampioni, G., Rinaldo, S.   +8 more
core   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Rol del glutamato y del sistema inmune en afecciones agudas y crónicas del SNC [PDF]

, 2005
Fil: Rodríguez de Viñas, Laura. Universidad Nacional de Cuyo. Facultad de Ciencias MédicasFil: Brandi, A.. Universidad Nacional de Cuyo.
Brandi, A., Rodríguez de Viñas, Laura
core  

A 47-Year Old Female with Muscular Rigidity, New-Onset Diabetes and Hypothyroidism [PDF]

, 2013
Background This case highlights a rare but devastating neurologic condition, Stiff Person Syndrome (SPS). While symptoms of muscular rigidity andspasms areassocia ted with numerous neuromuscular conditions, the association between SPS, autoimmune ...
Valentino, MD, PhD, Michael A.
core   +2 more sources