Results 111 to 120 of about 43,118 (240)

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Anti glutamate-decarboxylase antibodies: A liaison between localisation related epilepsy, stiff-person syndrome and type-1 diabetes mellitus [PDF]

, 2014
We present two patients with partial epilepsy, type-1 diabetes and stiff person syndrome associated with high serum autoantibody levels to glutamate-decarboxylase (anti-GAD). Both patients were or have suffered from additional autoimmune conditions.
Barcs, G., Folyovich, András, Kamondi, Anita, Soós, Z., Szűcs, Anna, Winkler, Gábor   +5 more
core  

A Roadmap for Breeding Sweet Tomatoes

Modern Agriculture, Volume 4, Issue 1, June 2026.
This graphical abstract outlines four breeding strategies for enhancing sugar content and sweetness in tomato fruits: (1) Identification of key genes and functional variant loci regulating fruit sugar accumulation through systematic germplasm collection, genome‐wide association studies (GWAS), map‐based cloning, and reverse genetics approaches.
Jie Chen, Hongjun Lyu, Jinzhe Zhang
wiley   +1 more source

Pengaruh Kerja Shift terhadap Kadar Glutamic Acid Decarboxylase 65 (GAD65) dalam Serum Darah

Jurnal Kesehatan, 2018
This study was to know shift work influences to increases levels of Glutamic Acid Decarboxylase 65 (GAD65) in the blood serum which is a marker of pancreatic beta cell destruction.The study method was quasi-experimental with the non-randomize pretest ...
Imam Cahyo Murwidi
doaj   +1 more source

Combination Versus Monotherapy in Acute Anti‐LGI1 Encephalitis: A Real‐World Dose Optimization Analysis

Neuropsychopharmacology Reports, Volume 46, Issue 2, June 2026.
Combined IVIg and 500 mg/day IVMP achieve superior efficacy over monotherapies in anti‐LGI1 encephalitis, with optimal safety. Higher‐dose IVMP (1000 mg) accelerates response but increases adverse events, particularly in diabetic patients. Cognitive deficits persist post‐treatment, necessitating long‐term management.
Yao Tan, Ming Sun, Qinqin Liu, Beibei Huang, Chao Wu, Jie Lu, Donglin Zhu   +6 more
wiley   +1 more source

Euglycemic diabetic ketoacidosis: The clinical concern of SGLT2 inhibitors

Journal of Clinical and Translational Endocrinology Case Reports, 2016
Euglycemic diabetic ketoacidosis is a post market warning in patients with type 1 diabetes and type 2 diabetes treated with SGLT-2 inhibitors. We report a case of a 39-year-old obese female with presumed type 2 diabetes for seven years who presented to ...
Jamila A. Benmoussa, MD, Matthew Clarke, MD, Amulya Penmetsa, MS4, Le Yu Khine, MD, Lina Leykina, MD, Keith Diaz, MD, Philip Otterbeck, MD   +6 more
doaj   +1 more source

Pharmacological characterization of GABAA receptors in taurine-fed mice [PDF]

, 2010
Background Taurine is one of the most abundant free amino acids especially in excitable tissues, with wide physiological actions. Chronic supplementation of taurine in drinking water to mice increases brain excitability mainly through alterations in the ...
William J L’Amoreaux, Alexandra Marsillo, Abdeslem El Idrissi, L’Amoreaux, William J   +3 more
core   +3 more sources

The Risk of Disease Progression of Type 1 Diabetes in First‐Degree Relatives of People With Type 1 Diabetes: Design and Rationale of a Prospective, Longitudinal Study in China

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4610-4618, June 2026.
ABSTRACT Aims In China, information on individuals who test positive for islet autoantibodies (IAb), including single IAb‐positive individuals and those with early‐stage Type 1 diabetes (T1D), and their risk of progression to Stage 3 T1D is limited. The goal of this study is to assess the risk of progression to T1D in first‐degree relatives (FDRs) of ...
Lixin Guo, Xiaoping Luo, Yan Bi, Bingyan Cao, Guanping Dong, Sheng Jiang, Guijun Qin, Hong Qiao, Zhongyan Shan, Tao Yang, Gaohui Zhu, Min Li, Sunyinyan Tang, Minlu Zhang, Wenjuan Li   +14 more
wiley   +1 more source

Toward Personalized Medicine in Type 1 Diabetes: Understanding How Patient Heterogeneity Influences Therapeutic Efficacy

Diabetes, Obesity and Metabolism, Volume 28, Issue 6, Page 4529-4545, June 2026.
ABSTRACT Pharmacologic interventions for type 1 diabetes (T1D) have advanced significantly in recent years with the advent of the first FDA approved therapy teplizumab for delaying symptomatic disease onset in 2022. Despite this progress, major hurdles remain in moving toward personalized medicine approaches for T1D.
Jasmine Pipella, Peter J. Thompson
wiley   +1 more source

Stiff-person syndrome with oculomotor and cerebellar disturbances

Анналы клинической и экспериментальной неврологии, 2017
Stiff-person syndrome is a rare sporadic disorder of the centralnervous system of unknown etiology. In the paper, a case of awoman with axial muscle rigidity, cerebellar and eye movementdisturbances is presented.
N. N. Yakhno, V. V. Golubeva, Yu. V. Mozolevsky, O. E. Zinovyeva, E. A. Katushkina, B. S. Shenkman, I. N. Chistyakov, Z. A. Podlubnaya, I. M. Vikhlyanzev   +8 more
doaj   +1 more source