Results 131 to 140 of about 43,118 (240)
Impact of screening programmes for type 1 diabetes in youth: A systematic review and meta‐analysis
Diabetic Medicine, Volume 43, Issue 5, May 2026.Abstract Aim To evaluate the impact of anti‐islet antibody (IAb) screening on the general population and first‐degree relatives (FDRs)/high‐risk individuals and evidence‐based follow‐up modalities. Methods We performed this review through systematic searches of PubMed, EMBASE, Cochrane Library, Web of Science, ClinicalTrials.gov and International ...
Roberto Franceschi +24 more
wiley +1 more source
Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. [PDF]
, 1995 Insulin-dependent diabetes mellitus (IDDM) is thought to be an immunologically mediated disease resulting in the complete destruction of the insulin-producing islets of Langerhans.
Bluestone, JA +7 more
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Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4326-4334, May 2026.ABSTRACT Aim To describe the first Italian experience with teplizumab administered under a compassionate use programme for adults with Stage 2 type 1 diabetes (T1D), and to evaluate its feasibility, safety and early metabolic outcomes in a real‐life clinical setting outside formal clinical trials.
V. Guarnotta +6 more
wiley +1 more source
Journal of Diabetes Investigation, Volume 17, Issue 5, Page 892-896, May 2026.Abstract A 61‐year‐old man visited our hospital with a sudden onset of polydipsia and polyuria occurring 5 days prior, accompanied by a 5‐kg weight loss. A month prior, his glycated hemoglobin level was 6.2%. Precisely 8 days before the first visit, he had a fever, and hyperglycemic symptoms began shortly thereafter.
Megumi Sato +6 more
wiley +1 more source
Baculovirus-Mediated Expression of Human 65 kDa and 67 kDa Glutamic Acid Decarboxylases in SF9 Insect Cells and Their Relevance in Diagnosis of Insulin-Dependent Diabetes Mellitus [PDF]
, 1993 cDNAs coding for the full-length human 65 and 67 kDa glutamic acid decarboxylases (GAD65 and GAD67) were amplified from pancreas and hippocampus cDNA libraries by polymerase chain reaction, respectively. Both cDNAs were inserted into a baculovirus vector
Abney, Charles C. +9 more
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Journal of Internal Medicine, Volume 299, Issue 5, Page 570-586, May 2026.Abstract Background and objective The development of Type 1 diabetes (T1D) is shaped by genetic predisposition and epigenetic regulation. Human leukocyte antigen (HLA) risk alleles are major genetic determinants, but the epigenetic landscape in relation to disease onset remains unclear.
Shamila D. Alipoor +6 more
wiley +1 more source
T cell cross-reactivity between coxsackievirus and glutamate decarboxylase is associated with a murine diabetes susceptibility allele. [PDF]
, 1994 Limited regions of amino acid sequence similarity frequently occur between microbial antigens and host proteins. It has been widely anticipated that during infection such sequence similarities could induce cross-reactive T cell responses, thereby ...
Kaufman, DL, Lehmann, PV, Tian, J
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GLUTAMIC ACID DECARBOXYLASE IN BRAIN
Journal of Biological Chemistry, 1951 E, ROBERTS, S, FRANKEL
openaire +2 more sources
Aspinous and sparsely-spinous stellate neurons in the visual cortex of rats contain glutamic acid decarboxylase. [PDF]
, 1978 Glutamic acid decarboxylase (GAD), the enzyme that synthesizes the neurotransmitter gamma-amino-butyric acid (GABA), has been localized in the rat visual cortex by immunocytochemical methods with both light and electron microscopy.
Ribak, CE
core +1 more source