Results 71 to 80 of about 42,820 (244)

Impact of screening programmes for type 1 diabetes in youth: A systematic review and meta‐analysis

Diabetic Medicine, EarlyView.
Abstract Aim To evaluate the impact of anti‐islet antibody (IAb) screening on the general population and first‐degree relatives (FDRs)/high‐risk individuals and evidence‐based follow‐up modalities. Methods We performed this review through systematic searches of PubMed, EMBASE, Cochrane Library, Web of Science, ClinicalTrials.gov and International ...
Roberto Franceschi, Enza Mozzillo, Marco Marigliano, Giulio Maltoni, Ernesto Maddaloni, Rocco Amendolara, Luca Bernardini, Riccardo Bonfanti, Federica Ciambrelli, Francesca Di Candia, Ludovica Fedi, Alessandro Fierro, Dario Iafusco, Antonio Iannilli, Letizia Leonardi, Claudio Maffeis, Evelina Maines, Riccardo Pertile, Claudia Piona, Ivana Rabbone, Carlo Ripoli, Andrea Scozzarella, Valentina Tiberi, Raffaella Buzzetti, Valentino Cherubini   +24 more
wiley   +1 more source

A unique combination of autoimmune limbic encephalitis, type 1 diabetes, and Stiff person syndrome associated with GAD-65 antibody

Annals of Indian Academy of Neurology, 2016
Antibodies to GAD-65 have been implicated in the pathogenesis of type 1 diabetes , limbic encephalitis and Stiff person syndrome, however these diseases rarely occur concurrently.
Chandra Mohan Sharma, Rajendra Kumar Pandey, Banshi Lal Kumawat, Dinesh Khandelwal, Pankaj Gandhi   +4 more
doaj   +1 more source

Teplizumab in Stage 2 Type 1 Diabetes: Clinical Practice Experience on Feasibility in 3 Adult Patients

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim To describe the first Italian experience with teplizumab administered under a compassionate use programme for adults with Stage 2 type 1 diabetes (T1D), and to evaluate its feasibility, safety and early metabolic outcomes in a real‐life clinical setting outside formal clinical trials.
V. Guarnotta, F. Pantò, E. Vigneri, G. Piombo, M. I. Mineo, L. Tomasello, G. Arnaldi   +6 more
wiley   +1 more source

Limbic encephalitis with antibodies to glutamic acid decarboxylase presenting with brainstem symptoms

Annals of Indian Academy of Neurology, 2015
Limbic encephalitis (LE) is a neurological syndrome that may present in association with cancer, infection, or as an isolate clinical condition often accompanying autoimmune disorders.
Faruk Incecik, Ozlem M Hergüner, Dincer Yildizdas, Ozden Horoz, Seyda Besen   +4 more
doaj   +1 more source

Ammonia assimilation in Bacillus polymyxa. 15N NMR and enzymatic studies [PDF]

, 1987
Pathways of ammonia assimilation into glutamic acid and alanine in Bacillus polymyxa were investigated by 15N NMR spectroscopy in combination with measurements of the specific activities of glutamate dehydrogenase, glutamine synthetase, glutamate ...
Kanamori, Keiko, Roberts, John D., Weiss, Richard L.   +2 more
core  

WONOEP XVII appraisal: The immunopathogenesis of epilepsy

Epilepsia, EarlyView.
Abstract There is a wealth of data indicating that the immune system plays an important role in seizure disorders. This includes autoimmune encephalitis, in which an immune response directed against neuronal antigens results in brain inflammation and subsequent seizure activity, as well as autoimmune‐associated epilepsy and neuroinflammatory changes ...
Nihan Çarçak, Said Al Maawal, Peravina Thergarajan, Tracie H. L. Tan, Vinod Kumar Mehta, Tamara Baker, David C. Henshall, Aristea S. Galanopoulou, Özlem Akman, Pablo M. Casillas‐Espinosa, Raman Sankar, Laura Librizzi, Adam E. Handel   +12 more
wiley   +1 more source

New-onset drug-resistant epilepsy in type 1 diabetes mellitus patient following COVID-19 vaccination: suspicious for autoimmune pathogenesis

BMC Neurology
Introduction Within the spectrum of epilepsies, autoimmune-associated epilepsy (AAE) reflects the complexity of its presentations including refractory seizures along with cognitive decline and behavioral or psychiatric dysfunction.
Sally Shaaban, Nirmeen A. Kishk, Amani Nawito, Ahmed Hamdy, Hadeer Elsaeed AboElfarh, Mohamed Elfieshy, Mohamed Eladrousi, Michael Baghdadi, Marwa El Sayed Elktob, Ibrahim Elmenshawi   +9 more
doaj   +1 more source

Effects of short‐term tofogliflozin treatment on the insulin secretory capacity of people with type 2 diabetes: A randomized controlled trial, the TOP‐ELM study

Journal of Diabetes Investigation, EarlyView.
Tofogliflozin was compared with metformin in treatment‐naïve people with type 2 diabetes for 4 weeks. Overall insulin secretory capacity did not improve; however, tofogliflozin was associated with an improved disposition index in individuals with poorer baseline glucose tolerance or greater improvement after treatment.
Maiko Miyamoto, Aika Miya, Akinobu Nakamura, Yuka Takahashi, Yuki Yamauchi, Shingo Yanagiya, Takahiro Takase, Mayuko Ono, Kiyohiko Takahashi, Kazufumi Okada, Hiraku Kameda, Kyu Yong Cho, Tatsuya Atsumi, on behalf of TOP‐ELM study group, Maiko Miyamoto, Aika Miya, Akinobu Nakamura, Hiraku Kameda, Kyu Yong Cho, Tatsuya Atsumi, Kazufumi Okada, Rimi Izumihara, Yuki Oe, Takahiro Takase, So Nagai, Akihiro Takahashi, Yuka Takahashi, Yuki Yamauchi, Hiromichi Kijima, Shinji Taneda, Jun Takeuchi, Kei Yokozeki, Saki Kuwabara, Yoshiaki Arimura, Shinichiro Kawata, Tomonori Sekizaki, Yuki Yamauchi, Shingo Yanagiya, Mayuko Ono, Kiyohiko Takahashi   +39 more
wiley   +1 more source

Anti-Yo and anti-glutamic acid decarboxylase antibodies presenting in carcinoma of the uterus with paraneoplastic cerebellar degeneration: a case report

Journal of Medical Case Reports, 2012
Introduction Paraneoplastic cerebellar degeneration is a rare non-metastatic manifestation of malignancy. In this report, to the best of our knowledge we describe for the first time a diagnosis of paraneoplastic cerebellar degeneration several months ...
Panegyres Peter K, Graves Angela
doaj   +1 more source

Reversal of Hyperglycemia and Suppression of Type 1 Diabetes in the NOD Mouse with Apoptotic DNA Immunotherapy™ (ADi™), ADi-100

Biomedicines, 2020
The antigen-specific apoptotic DNA immunotherapeutic, ADi-100, is designed to suppress type 1 diabetes and consists of two DNA plasmids encoding genetic sequences of the apoptosis-inducing molecule, BAX, and the secreted form of the autoantigen, glutamic
David G. Alleva, Melika Rezaee, Linda Yip, Gang Ren, Jarrett Rosenberg, Waldo Concepcion, Alan Escher, Shahrokh Shabahang, Avnesh S. Thakor   +8 more
doaj   +1 more source