Results 151 to 160 of about 472,248 (234)

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

Corrigendum: Protein Kinase C Phosphorylates the System N Glutamine Transporter SN1 (Slc38a3) and Regulates Its Membrane Trafficking and Degradation

Frontiers in Endocrinology, 2017
Lise Sofie H. Nissen-Meyer, Lise Sofie H. Nissen-Meyer, Farrukh Abbas Chaudhry, Farrukh Abbas Chaudhry   +3 more
doaj   +1 more source

Studying clonal heterogeneity of acute myeloid leukemia under nutrient and chemotherapy stress. [PDF]

Blood Adv
Mayerhofer C, Crompton E, Mayerhofer E, Kristiansen T, Fukushima T, Keyes S, Sharda A, Li D, Da Silva C, Shrestha D, Kiem A, Feuchtinger T, Scadden DT, Miller PG.   +13 more
europepmc   +1 more source

Oxygen Supply of Islets of Langerhans by Photosynthetically Active Microalgae in Bioprinted Co‐Cultures Maintains Their Function in a Hypoxic Environment

Advanced Healthcare Materials, EarlyView.
This study developed a bioprinted co‐culture system embedding rat pancreatic islets and Scenedesmus sp. microalgae spatially defined in close vicinity. Red light was found optimal to ensure microalgal photosynthesis while maintaining islet viability and functionality. A tailored co‐culture medium supported both cell types.
Finn Dani, Sarah Duin, Ashwini Rahul Akkineni, Susann Lehmann, Barbara Ludwig, Michael Kühl, Michael Gelinsky, Anja Lode   +7 more
wiley   +1 more source

Glutamine transporter SLC1A5 inhibits autophagy-mediated CD276 degradation to promote esophageal cancer progression. [PDF]

Cancer Biol Ther
Wang C, Zhang H, Guan C, Li Y, Yang S, Huang L.   +5 more
europepmc   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

A shift in the cellular redox state redirects aspartate for export under glucose deprivation. [PDF]

Cancer Metab
Konrad B, Bluemel G, Haitzmann T, Frech T, Vandekeere A, Planque M, Bubalo V, Schindlmaier K, Jäger V, Dengler MA, Stryeck S, Brcic L, Lindenmann J, Stiegler P, Bresilla D, Madreiter-Sokolowski CT, Madl T, Eichmann TO, Kneidinger N, Fendt SM, Leithner K.   +20 more
europepmc   +1 more source

Engineered Protein‐Based Ionic Conductors for Sustainable Energy Storage Applications

Advanced Materials, EarlyView.
Rational incorporation of charged residues into an engineered, self‐assembling protein scaffold yields solid‐state protein films with outstanding ionic conductivity. Salt‐doping further enhances conductivity, an effect amplified in the engineered variants. These properties enable the material integration into an efficient supercapacitor.
Juan David Cortés‐Ossa, Paolo Blesio, Marcial Fernandez‐Castro, Lisa Almonte, Maxence Fernandez, Mantas Liutkus, Perumal Pandurangan, Carlos Sabater, Aitor Villaverde, Manuel Melle‐Franco, Nurit Ashkenasy, Felipe Jiménez‐Ángeles, M. Carmen Morant‐Miñana, M. Reyes Calvo, Aitziber L. Cortajarena   +14 more
wiley   +1 more source

Revised safety evaluation of the food enzyme protein-glutamine γ-glutamyltransferase from the non-genetically modified <i>Streptomyces mobaraensis</i> strain M2020197. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Van Loveren H, Vernis L, Cavanna D, Aguilera J, Fernàndez-Fraguas C, Liu Y.   +16 more
europepmc   +1 more source

Porous Hybrid Soft Actuators From Liquid Crystal Networks and Lyotropic Chromonic Liquid Crystal Templated Hydrogels

Advanced Materials, EarlyView.
The graphic illustrates the design of a hybrid bilayer composed of a liquid crystal hydrogel (LCH) and a liquid crystal network (LCN). The figure highlights the magnetic alignment of the chromonic hydrogel and the thermal‐responsive actuation of the LCN along with the LCH when both layers are aligned or misaligned, enabling programmable, light‐driven ...
Ramón Santiago Herrera Restrepo, Irving Hafed Tejedor García, Matthew Gene Scarfo, Negin Bouzari, Negar Rajabi, Olga Bantysh, Joel Torres‐Andrés, Christopher W. V. James, Maria Guix, Amirreza Aghakhani, Jordi Ignés‐Mullol, Salvador Pané, Josep Puigmartí‐Luis, Hamed Shahsavan   +13 more
wiley   +1 more source