Results 201 to 210 of about 475,767 (259)

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Effect and safety of nutritional supplements on clinical outcomes in patients with acute pancreatitis: a systematic review and network meta-analysis. [PDF]

Nutr J
Su K, Duan R, Wu Y.
europepmc   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source

Glutamine enhances endothelial cell survival and vasodilation by increasing glutathione to reduce oxidative stress. [PDF]

Physiol Rep
Kheradmand M, Sangha G, Sissons CM, Sun M, Zhou X, Smith LV, Bauer M, Chen C, Clyne AM.   +8 more
europepmc   +1 more source

Safety evaluation of the food enzyme protein-glutamine γ-glutamyltransferase from the genetically modified <i>Bacillus licheniformis</i> strain NZYM-TR. [PDF]

EFSA J
EFSA Panel on Food Enzymes (FEZ), Zorn H, Barat Baviera JM, Bolognesi C, Catania F, Gadermaier G, Greiner R, Mayo B, Mortensen A, Roos YH, Solano MLM, Van Loveren H, Vernis L, Cavanna D, Fernandez Fraguas C, Peluso S, Tokic V, Liu Y.   +17 more
europepmc   +1 more source

Significance of SLC1A5 expression in head and neck squamous cell carcinoma: A bioinformatics and in-vitro analysis. [PDF]

J Oral Biol Craniofac Res
Kaarunya S, Sinduja P, Yuwanati M, Mullainathan S.   +3 more
europepmc   +1 more source

ppAT drives glutamine-dependent purine biosynthesis and malignant progression in hepatocellular carcinoma. [PDF]

BMC Cancer
Zhou J, Dong C, Xu S, Wang J, Ye H, Fan X, Li S, Wang S.   +7 more
europepmc   +1 more source

Immunometabolism in lung cancer - The link between metabolism and immune response. [PDF]

iScience
Eivazzadeh Y, Orooji N, Eskandari T, Tarahomi M, Tavassoli Razavi F, Haghmorad D.   +5 more
europepmc   +1 more source

Metabolic and redox adaptations of the corneal endothelium: From metabolic plasticity to therapeutic opportunities. [PDF]

Redox Biol
Jiang D, Hui Neo DJ, Swee-Lim Peh G, Jin P, Chen W, Mehta JS.   +5 more
europepmc   +1 more source