Results 41 to 50 of about 538,260 (299)

4-Hydroxyphenylpyruvate Dioxygenase-Like Protein Promotes Pancreatic Cancer Cell Progression and Is Associated With Glutamine-Mediated Redox Balance

open access: yesFrontiers in Oncology, 2021
Tumor cells develop a series of metabolic reprogramming mechanisms to meet the metabolic needs for tumor progression. As metabolic hubs in cells, mitochondria play a significant role in this process, including energy production, biosynthesis, and redox ...
Xianglai Ye   +33 more
doaj   +1 more source

Rat liver responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia

open access: yesBrazilian Journal of Medical and Biological Research, 2001
Hepatic responsiveness to gluconeogenic substrates during insulin-induced hypoglycemia was investigated. For this purpose, livers were perfused with a saturating concentration of 2 mM glycerol, 5 mM L-alanine or 5 mM L-glutamine as gluconeogenic ...
H.M. de Souza   +5 more
doaj   +1 more source

Glutamine Cooperatively Upregulates Lipopolysaccharide-Induced Nitric Oxide Production in BV2 Microglial Cells through the ERK and Nrf-2/HO-1 Signaling Pathway

open access: yesAntioxidants, 2020
Glutamine (Gln) is a nonessential α-amino acid for protein biosynthesis. However, the mechanism through which Gln regulates NO production in microglial cells is still unclear.
Rajapaksha Gedara Prasad Tharanga Jayasooriya   +4 more
doaj   +1 more source

A metabolic shift toward glycolysis enables cancer cells to maintain survival upon concomitant glutamine deprivation and V-ATPase inhibition

open access: yesFrontiers in Nutrition, 2023
It is widely known that most cancer cells display an increased reliance on glutaminolysis to sustain proliferation and survival. Combining glutamine deprivation with additional anti-cancer therapies is an intensively investigated approach to increase ...
Florian Lengauer   +5 more
doaj   +1 more source

The Glutamine Transporters and Their Role in the Glutamate/GABA-Glutamine Cycle

open access: yes, 2016
Glutamine is a key amino acid in the CNS, playing an important role in the glutamate/GABA–glutamine cycle (GGC). In the GGC, glutamine is transferred from astrocytes to neurons, where it will replenish the inhibitory and excitatory neurotransmitter pools.
Schousboe, Arne   +5 more
core   +1 more source

Further Concerns About Glutamine: A Case Report on Hyperammonemic Encephalopathy. [PDF]

open access: yes, 2015
OBJECTIVE We report a case of a woman with hyperammonemic encephalopathy following glutamine supplementation. DESIGN Case report. INTERVENTIONS Plasma amino acid analysis suggestive of a urea cycle defect and initiation of a treatment with
Weck, Anja   +4 more
core   +2 more sources

Formation of Glutamine and Activities of Glutamine Synthetase in Goats

open access: yesThe Japanese Journal of Veterinary Science, 1977
When goats were administered orally with urea in a dose of 0.3 g per kg of body weight, the blood concentration of glutamine-N in the jugular vein increased to about 6μg per ml of plasma, reflecting the removal of ammonia by forming glutamine in the animal body. The blood glutamine seemed to undergo a more rapid turnover than the blood urea.
IDE, Yu, MATSUMOTO, Hajime
openaire   +3 more sources

Parenteral Glutamine Supplement has Synergic Effects in Minimally Invasive Surgery a Subtotal Gastrectomy Patients

open access: yes, 2014
Background/Aims: Exogenous glutamine supplement is known to improve morbidity and mortality of critically-ill patients. This study was conducted to elucidate the role of glutamine in minimally invasive surgery.
Chen, Chien-Chia;Chang, Tung-Cheng;Wang, Ming-Yang;Wu, Ming-Hsun;Lin, Ming-Tsan   +1 more
core   +1 more source

Possibility of medicinal correction of disorders in metabolic cycle of neurotoxic transmitter glutamate in retina with neurotropic drugs during experimental glaucoma

open access: yesPatologìâ, 2012
Adult rabbits with experimental glaucoma were used in this study. We studied glutamate and glutamine levels and glutamine synthetase, glutamate oxidase and glutaminase activity in the eye tissue during glaucoma process.
V. M. Serdyuk
doaj   +1 more source

Parenteral glutamine in critical illness : just what the gut needs [PDF]

open access: yes, 2012
The role of glutamine as a metabolic fuel for the starving intestines, its capacity to limit bacterial translocation, lung sepsis and a pro-inflammatory cytokine response are reviewed in the context of uncertainities regarding current recommendations for
Pullicino, Edgar
core  

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