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Glutamine Transport and the Role of the Glutamine Translocator in Chloroplasts [PDF]
Plant Physiology, 1988 The transport of l-[(14)C]glutamine in oat (Avena sativa L.) and spinach (Spinacia oleracea L.) chloroplasts was studied by a conventional single-layer and a newly developed stable double-layer silicone oil filtering system. [(14)C]Glutamine was actively transported into oat chloroplasts against a concentration gradient.
J, Yu, K C, Woo
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The Journal of Nutrition, 2001 Glutamine is the most abundant free amino acid in the human body; it is essential for the growth of normal and neoplastic cells and for the culture of many cell types. Cancer has been described as a nitrogen trap. The presence of a tumor produces great changes in host glutamine metabolism in such a way that host nitrogen metabolism is accommodated to ...
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eLife, 2017 Many mammalian cancer cell lines depend on glutamine as a major tri-carboxylic acid (TCA) cycle anaplerotic substrate to support proliferation. However, some cell lines that depend on glutamine anaplerosis in culture rely less on glutamine catabolism to ...
Alexander Muir +5 more
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Metabolic Analysis of DFO-Resistant Huh7 Cells and Identification of Targets for Combination Therapy
Metabolites, 2023 Hepatocellular carcinoma (HCC) is one of the most refractory cancers with a high rate of recurrence. Iron is an essential trace element, and iron chelation has garnered attention as a novel therapeutic strategy for cancer.
Koichi Fujisawa +4 more
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The Regulation of Glutamine Metabolism in Candida utilis: the Role of Glutamine in the Control of Glutamine Synthetase [PDF]
Journal of General Microbiology, 1974 SUMMARY: In Candida utilis, the amount of glutamine synthetase is finely attuned to the availability of ammonia in the culture medium, and any change in ammonia availability results in a compensatory adjustment to enzyme level. In yeast growing with different sources of nitrogen there was a good inverse correlation between the rate of enzyme synthesis ...
A R, Ferguson, A P, Sims
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Journal of Nutrition and Metabolism, 2016 Glutamine supplementation in specific groups of critically ill patients results in favourable clinical outcome. Enhancement of citrulline and arginine synthesis by glutamine could serve as a potential mechanism.
Mechteld A. R. Vermeulen +7 more
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Journal of Fungi, 2021 Glutamine is a non-essential amino acid that acts as a principal source of nitrogen and nucleic acid biosynthesis in living organisms. In Saccharomyces cerevisiae, glutamine synthetase catalyzes the synthesis of glutamine.
Osakina Aron +7 more
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Alloferon Affects the Chemosensitivity of Pancreatic Cancer by Regulating the Expression of SLC6A14
Biomedicines, 2022 Pancreatic cancer (PCa), one of the most malignant solid tumors, has a high mortality rate. Although there have been many trials of chemotherapeutic drugs such as gemcitabine, the mortality rates remain significantly higher than for other types of cancer.
Hyejung Jo +9 more
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Journal of Public Health in Africa, 2022 The aim of this research was studied the influence of giving Glutamine, Glucose Unhydrate and Moringa oleifera the blood lymphocyte of white rat (Rattus novergicus) Strain Wistar that was induced with protein energy malnutrtion (PEM).
Septa Katmawanti +9 more
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Glutamine metabolism in the proliferation of GS-expression pituitary tumor cells
Endocrine Connections, 2020 Objective: Many cancer cells cannot survive without exogenous glutamine (Gln); however, cancer cells expressing glutamine synthetase (GS) do not have this restriction.
Jintao Hu +6 more
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