Results 11 to 20 of about 538,260 (299)

METTL7A Downregulation Drives SLC1A5-Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8⁺ T Cell Immunity in Gastric Cancer. [PDF]

Adv Sci (Weinh)
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Sun M, Dang S, Zhou D, Ding L, Sun X, Suo W, Niu J, Yang Q, Zhang Z, Sun Y, Li J, Chen Z, Ban T, Wang Y, Li T, Liu M, Li G.   +16 more
europepmc   +2 more sources

Cellular and molecular outcomes of glutamine supplementation in the brain of succinic semialdehyde dehydrogenase‐deficient mice

JIMD Reports, 2020
Succinic semialdehyde dehydrogenase deficiency (SSADHD) manifests with low levels of glutamine in the brain, suggesting that central glutamine deficiency contributes to pathogenesis.
Madalyn N. Brown, K. Michael Gibson, Michelle A. Schmidt, Dana C. Walters, Erland Arning, Teodoro Bottiglieri, Jean‐Baptiste Roullet   +6 more
doaj   +1 more source

Early Stepdown Weaning of Dairy Calves with Glutamine and Branched-Chain Amino Acid Supplementations

Animals, 2022
The study objective was to examine the effects of supplementing Gln and BCAA on the SFI and ADG of weaning dairy calves. Holstein heifer calves (11 calves /treatment) at 35 d of age were assigned to: (1) no amino acids (CTL), (2) Gln (8.0 g/d) alone (GLN)
Janaka Wickramasinghe, Can Ayhan Kaya, Donald Beitz, Ranga Appuhamy   +3 more
doaj   +1 more source

SLC1A5 provides glutamine and asparagine necessary for bone development in mice

eLife, 2021
Osteoblast differentiation is sequentially characterized by high rates of proliferation followed by increased protein and matrix synthesis, processes that require substantial amino acid acquisition and production.
Deepika Sharma, Yilin Yu, Leyao Shen, Guo-Fang Zhang, Courtney M Karner   +4 more
doaj   +1 more source

Glutamine and glutamate supplementation raise milk glutamine concentrations in lactating gilts

Journal of Animal Science and Biotechnology, 2012
Glutamine is the most abundant amino acid in milk, and lactation is associated with increased glutamine utilization both for milk synthesis and as a fuel for the enlarged small intestine.
Manso Helena, Filho Helio, de Carvalho Luiz E, Kutschenko Marianne, Nogueira Eduardo T, Watford Malcolm   +5 more
doaj   +1 more source

Glutamine

Journal of British Surgery, 1996
Abstract Glutamine is the most abundant free amino acid in the circulation. It is a primary fuel for rapidly dividing cells and plays a key role in the transport of nitrogen between organs. Although glutamine is absent from conventional regimens aimed at nutritional support, glutamine deficiency can occur during periods of metabolic ...
J C, Hall, K, Heel, R, McCauley
openaire   +2 more sources

Glutamine and the Bowel [PDF]

The Journal of Nutrition, 2001
Since the pioneering work of Windmueller and Spaeth, the importance of glutamine to the support of intestinal mucosal metabolic function has become generally accepted. Nevertheless, the mechanisms underlying this role still remain obscure. This paper explores a number of questions: 1) Is glutamine essential for intestinal function?
P J, Reeds, D G, Burrin
openaire   +2 more sources

Glutamine in critical care:current evidence from systematic reviews [PDF]

, 2006
Glutamine, the most abundant amino acid in the body, is thought to become conditionally essential in critical illness. Some of the important roles for glutamine are as a carrier for inter-organ N, a preferred fuel for enterocytes and cells of the immune ...
Avenell, Alison
core   +1 more source

Randomised trial of glutamine and selenium supplemented parenteral nutrition for critically ill patients [PDF]

, 2007
Background: Mortality rates in the Intensive Care Unit and subsequent hospital mortality rates in the UK remain high. Infections in Intensive Care are associated with a 2–3 times increased risk of death.
Vale, Luke D, Campbell, MK, Cook, Jonathan Alistair, Simpson, William G., Cook Jonathon, Battison, CG, Cook, J, Milne, AC, Andrews, Peter J.D., Campbell, Marion K, Vale, LD, Peter JD Andrews, Trials Management Group, Andrews, Peter J D, Croal, BL, Battison, Claire G., Milne Anne C, Simpson William G, De Verteuil, Robyn, de Verteuil Robyn, William G Simpson, Anne C Milne, ?, ?, Norrie, John David, Avenell, A, null null, Noble, David W., Milne, Anne C, Vale Luke D, Noble David W, Vale, Luke David, Campbell, Marion Kay, Norrie, John, Claire G Battison, Simpson, William G, Andrews, PJD, Avenell Alison, Robyn de Verteuil, Cook, Jonathon, Croal, Bernard L., de Verteuil, R, Jonathon Cook, Battison Claire G, Campbell Marion K, Bernard L Croal, Norrie John, Noble, David W, Croal, Bernard L, David W Noble, John Norrie, Andrews Peter JD, Noble, DW, Alison Avenell, Marion K Campbell, Croal Bernard L, Simpson, WG, Norrie, J, Avenell, Alison, Battison, Claire G, Milne, Anne Catherine, Luke D Vale   +60 more
core   +2 more sources

Therapeutic Potential of Glutamine Pathway in Lung Cancer

Frontiers in Oncology, 2022
Cancer cells tend to obtain the substances needed for their development depending on altering metabolic characteristics. Among the reorganized metabolic pathways, Glutamine pathway, reprogrammed to be involved in the physiological process including ...
Enyu Tang, Siyang Liu, Zhiming Zhang, Rixin Zhang, Dejing Huang, Tong Gao, Tianze Zhang, Guangquan Xu   +7 more
doaj   +1 more source