Results 131 to 140 of about 216,468 (357)

Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors†

Journal of Medicinal Chemistry, 2012
Mycobacterium tuberculosis glutamine synthetase (MtGS) is a promising target for antituberculosis drug discovery. In a recent high-throughput screening study we identified several classes of MtGS inhibitors targeting the ATP-binding site.
J. Gising, M. Nilsson, Luke R. Odell, S. Yahiaoui, Martin Lindh, H. Iyer, A. M. Sinha, B. Srinivasa, M. Larhed, S. Mowbray, A. Karlén   +10 more
semanticscholar   +1 more source

Modulating Lysine Crotonylation in Ulcerative Colitis Maintains Mitochondrial Homeostasis

Exploration, EarlyView.
NaCr promotes KCr to impede the inflammatory progression of ulcerative colitis. KCr induces mitophagy by activating the PINK1/PARKIN pathway to restrict NLRP3 inflammasome activation, thereby decreasing the production and release of various inflammatory cytokines, such as IL‐1β and TNF‐α. KCr induces mitophagy and inhibits NLRP3 inflammasome activation
Tongtong Liu, Binyan Lin, Ying Zhang, Jiayu Su, Xiaochao Hu, Xuan Wang, E‐Hu Liu, Shijia Liu   +7 more
wiley   +1 more source

Specificities of Human Hepatocellular Carcinoma Developed on Non-Alcoholic Fatty Liver Disease in Absence of Cirrhosis Revealed by Tissue Extracts 1H-NMR Spectroscopy

Metabolites, 2017
There is a rising incidence of non-alcoholic fatty liver disease (NAFLD) as well as of the frequency of Hepato-Cellular Carcinoma (HCC) associated with NAFLD.
Camille Teilhet, Daniel Morvan, Juliette Joubert-Zakeyh, Anne-Sophie Biesse, Bruno Pereira, Sylvie Massoulier, Pierre Dechelotte, Denis Pezet, Emmanuel Buc, Géraldine Lamblin, Michel Peoc’h, Jack Porcheron, Marie-Paule Vasson, Armando Abergel, Aicha Demidem   +14 more
doaj   +1 more source

Oligodendroglioma cells lack glutamine synthetase and are auxotrophic for glutamine, but do not depend on glutamine anaplerosis for growth [PDF]

, 2018
In cells derived from several types of cancer, a transcriptional program drives high consumption of glutamine (Gln), which is used for anaplerosis, leading to a metabolic addiction for the amino acid. Low or absent expression of Glutamine Synthetase (GS),
Andreoli, Roberta, Bianchi, Massimiliano G., Bussolati, Ovidio, Chiu, Martina, Ciociola, Tecla, Lagrasta, Costanza A M, Ottaviani, Laura, Tardito, Saverio, Taurino, Giuseppe   +8 more
core   +2 more sources

Bifidobacterium longum subsp. longum CCFM1375 Mitigates Chronic Kidney Disease Progression via Gut Microbiota Modulation and Gut Barrier Restoration

Food Frontiers, EarlyView.
(1) Bifidobacterium longum subsp. longum CCFM1375 restored gut barrier integrity by upregulating ZO‐1/ZO‐2 and suppressing IL‐6/TNF‐α, thereby reducing serum LPS and improving creatinine/BUN levels. (2) Reshaped gut microbiota: enriched beneficial species (Faecalibaculum rodentium, Asaccharobacter celatus, Adlercreutzia equolifaciens) while suppressing
Hongchao Wang, Xinchen Lv, Yue Zhang, Jinlin Zhu, Jia Hua, Bin Liu, Jianxin Zhao, Hao Zhang, Wei Chen, Wenwei Lu, Zhijian Zhang, Liang Wang   +11 more
wiley   +1 more source

Tea and Blood–Brain Barrier Homeostasis: Potential Mechanisms and Improvement Strategies

Food Frontiers, EarlyView.
Abstract The blood–brain barrier (BBB), a selective interface regulating cerebral substance exchange, plays a crucial role in maintaining cognitive function and metabolic balance. While tea consumption has been traditionally associated with health benefits, its specific effects on BBB integrity warrant systematic investigation. This review demonstrates
Rongbosen Yue, Haitao Wen, Lian He, Yan Liu, Zeng Liang, Liyong Luo   +5 more
wiley   +1 more source

Metabolic enzymes in glial cells of the honeybee brain and their associations with aging, starvation and food response.

PLoS ONE, 2018
The honey bee has been extensively studied as a model for neuronal circuit and memory function and more recently has emerged as an unconventional model in biogerontology. Yet, the detailed knowledge of neuronal processing in the honey bee brain contrasts
Ashish K Shah, Claus D Kreibich, Gro V Amdam, Daniel Münch   +3 more
doaj   +1 more source

Independent genetic regulation of glutamine synthetase and its inactivating (adenylating) enzyme in E. coli [PDF]

, 1969
Frederick Varricchio, Helmut Holzer
openalex   +1 more source

Novel aspects of glutamine synthetase in ammonia homeostasis

Neurochemistry International, 2020
Yun Zhou, T. Eid, B. Hassel, N. Danbolt
semanticscholar   +1 more source

Hydrocortisone requirement for the induction of glutamine synthetase in chick-embryo retinas [PDF]

, 1968
Liane Reif‐Lehrer, Harold Amos
openalex   +1 more source