Results 141 to 150 of about 78,410 (212)

Amino Acid Stress Response Genes Contribute to a 25‐Fold Increased Risk of L‐Asparaginase–Induced Hypersensitivity

Pediatric Blood &Cancer, Volume 72, Issue 6, June 2025.
ABSTRACT Background L‐asparaginase is essential in treating pediatric acute lymphoblastic leukemia (ALL) but is limited by hypersensitivity reactions in up to 70% of patients, leading to severe, dose‐limiting complications and compromised event‐free survival. Procedure This study conducted a genome‐wide association study (GWAS) in a discovery cohort of
Spencer J. Anderson, Erika N. Scott, Edward J. Raack, Wan‐Chun Chang, Miguel Córdova‐Delgado, Jessica N. Trueman, Catrina M. Loucks, S. Rod. Rassekh, Colin J. D. Ross, Bruce C. Carleton, the Canadian Pharmacogenomics Network for Drug Safety (CPNDS) consortium   +10 more
wiley   +1 more source

Effective Targeting of Glutamine Synthetase with Amino Acid Analogs as a Novel Therapeutic Approach in Breast Cancer. [PDF]

Int J Mol Sci
Abdelsattar S, Al-Amodi HS, Kamel HF, Al-Eidan AA, Mahfouz MM, El Khashab K, Elshamy AM, Basiouny MS, Khalil MA, Elawdan KA, Elsaka S, Mohamed SE, Khalil H.   +12 more
europepmc   +1 more source

A revised view on the evolution of glutamine synthetase isoenzymes in plants. [PDF]

Plant J, 2022
Valderrama-Martín JM, Ortigosa F, Ávila C, Cánovas FM, Hirel B, Cantón FR, Cañas RA.   +6 more
europepmc   +1 more source

Genome‐wide association study and BSR‐seq identify nitrate reductase–related genes in rice landraces (Oryza sativa L.)

The Plant Genome, Volume 18, Issue 2, June 2025.
Abstract Nitrogen (N) is an essential nutrient for rice (Oryza sativa L.) growth and development. However, the lower nitrogen use efficiency (NUE) results in an N fertilizer surplus, which causes many environmental problems. In this study, genome‐wide association studies were used to detect nitrate reductase (NR)‐related loci in 419 rice landraces ...
Shuangshuang Luo, Zuyu Liao, Shilv Huang, Xiuzhong Xia, Zongqiong Zhang, Baoxuan Nong, Tongping Luo, Chenli Zhu, Can Chen, Hui Guo, Rui Feng, Yinghua Pan, Shuhui Liang, Yongcheng Li, Jianhui Liu, Yongfu Qiu, Danting Li, Xinghai Yang   +17 more
wiley   +1 more source

CitGATA7 interact with histone acetyltransferase CitHAG28 to promote citric acid degradation by regulating the glutamine synthetase pathway in citrus. [PDF]

Mol Hortic
Lin X, Li S, Shi Y, Ma Y, Li Y, Tan H, Zhang B, Xu C, Chen K.   +8 more
europepmc   +1 more source

Age-Associated Upregulation of Glutamate Transporters and Glutamine Synthetase in Senescent Astrocytes In Vitro and in the Mouse and Human Hippocampus. [PDF]

ASN Neuro, 2023
Matias I, Diniz LP, Araujo APB, Damico IV, de Moura P, Cabral-Miranda F, Diniz F, Parmeggiani B, de Mello Coelho V, Leite REP, Suemoto CK, Ferreira GC, Kubrusly RCC, Gomes FCA.   +13 more
europepmc   +1 more source

Nitrosarchaeum haohaiensis sp. Nov. CL1T: Isolation and Characterisation of a Novel Ammonia‐Oxidising Archaeon From Aquatic Environments

Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.
Following a 3.5‐year enrichment cultivation period, a rapid‐growing ammonia‐oxidising archaeon, designated CL1T, was isolated from the East China Sea. Strain CL1T represents a new species within the Nitrosarchaeum genus and is capable of effectively oxidising ammonia at both low and high concentrations through the GS‐GOGAT and GDH pathways. Furthermore,
Hailing Li, Lingqi Zhuang, Haoyun Cai, Yimin Ni, Ting Chu, Lanming Chen, Yongxin Yu, Yongjie Wang   +7 more
wiley   +1 more source

Activation of glutamine synthetase (GS) as a new strategy for the treatment of major depressive disorder and other GS-related diseases. [PDF]

Acta Pharmacol Sin
Kang JS, Kim H, Baek JH, Song M, Park H, Jeong W, Chung HJ, Yoo DY, Lee DK, Park SW, Kim HJ.   +10 more
europepmc   +1 more source

Glutamine Synthetase Contributes to the Regulation of Growth, Conidiation, Sclerotia Development, and Resistance to Oxidative Stress in the Fungus Aspergillus flavus. [PDF]

Toxins (Basel), 2022
Wang S, Lin R, Tumukunde E, Zeng W, Bao Q, Wang S, Wang Y.   +6 more
europepmc   +1 more source

VCP Promotes Cholangiocarcinoma Development by Mediating BAP1 Ubiquitination‐Dependent Degradation

Cancer Science, Volume 116, Issue 6, Page 1579-1591, June 2025.
It demonstrates the tumor‐suppressive roles of BAP1 in CCA: BAP1 significantly inhibits CCA cell proliferation and tumor progression. It identifies VCP as a key upstream regulator mediating BAP1 homeostasis: VCP binds to BAP1 and promotes the latter's ubiquitination degradation via the ubiquitin‐proteasome pathway.
Peiying Zhang, Xiangning Liu, Yue Liu, Hongdao Zhu, Churun Zheng, Qi Ling, Fangjie Yan, Qiaojun He, Hong Zhu, Tao Yuan, Bo Yang   +10 more
wiley   +1 more source