A Prognostic Activity of Glutaredoxin 1 Protein (Grx1) in Colon Cancer. [PDF]
Int J Mol SciGlutaredoxin 1 (Grx1) is an essential enzyme that regulates redox signal transduction and repairs protein oxidation by reversing S-glutathionylation, an oxidative modification of protein cysteine residues.
Brzozowa-Zasada M +6 more
europepmc +4 more sources
Role of Glutaredoxin-1 and Glutathionylation in Cardiovascular Diseases. [PDF]
Int J Mol Sci, 2020 Cardiovascular diseases are the leading cause of death worldwide, and as rates continue to increase, discovering mechanisms and therapeutic targets become increasingly important.
Burns M +7 more
europepmc +5 more sources
Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation. [PDF]
Antioxid Redox Signal, 2020 Significance: Over the past several years, oxidative post-translational modifications of protein cysteines have been recognized for their critical roles in physiology and pathophysiology.
Matsui R +7 more
europepmc +5 more sources
Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. [PDF]
Antioxid Redox Signal, 2017 Aims: Nonalcoholic fatty liver (NAFL) is a common liver disease associated with metabolic syndrome, obesity, and diabetes that is rising in prevalence worldwide.
Shao D +10 more
europepmc +5 more sources
Novel chloroacetamido compound CWR-J02 is an anti-inflammatory glutaredoxin-1 inhibitor. [PDF]
PLoS ONE, 2017 Glutaredoxin (Grx1) is a ubiquitously expressed thiol-disulfide oxidoreductase that specifically catalyzes reduction of S-glutathionylated substrates.
Olga Gorelenkova Miller +8 more
doaj +5 more sources
Macrophage-restricted overexpression of glutaredoxin 1 protects against atherosclerosis by preventing nutrient stress-induced macrophage dysfunction and reprogramming. [PDF]
Atherosclerosis, 2023 Background and Aims: Deficiency in the thiol transferase glutaredoxin 1 (Grx1) in aging mice promotes in a sexually dimorphic manner the dysregulation of macrophages and atherogenesis. However, the underlying mechanisms were not known. Here we tested the
Ahn YJ +5 more
europepmc +2 more sources
The anti-fibrotic drug pirfenidone inhibits liver fibrosis by targeting the small oxidoreductase glutaredoxin-1. [PDF]
Sci Adv, 2021 Pirfenidone inhibits HSC activation and liver fibrosis by targeting glutaredoxin-1 and reducing Smad3 glutathionylation.
Xi Y +19 more
europepmc +2 more sources
The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function.
Experimental Eye Research, 2023 Glutaredoxins (Grx1 and Grx2) are thiol-repair antioxidant enzymes that play vital roles in cellular redox homeostasis and various cellular processes. This study aims to evaluate the functions of the glutaredoxin (Grx) system, including glutaredoxin 1 ...
Jinmin Zhang +4 more
semanticscholar +3 more sources
Glutaredoxin 1 Deficiency Leads to Microneme Protein-Mediated Growth Defects in Neospora caninum [PDF]
Frontiers in Microbiology, 2020 Neospora caninum is an obligate intracellular protozoan parasite that infects a wide range of mammalian species and causes spontaneous abortion in cattle. N. caninum is exposed to oxidative stress during its life cycle.
Xingju Song +13 more
doaj +2 more sources
Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1 [PDF]
Proceedings of the National Academy of Sciences, 2013 Significance Embryonic development is one of the most amazing miracles in nature. The proteins and signaling events driving this highly complex process are far from being elucidated completely. For a long time, an important role of protein reduction and oxidation during development has been assumed.
Lars, Bräutigam +14 more
openaire +3 more sources