Results 31 to 40 of about 135,439,936 (222)
Glutaredoxin 1 Downregulation in the Substantia Nigra Leads to Dopaminergic Degeneration in Mice [PDF]
Movement Disorders, 2020 Parkinson's disease (PD) is characterized by a severe loss of the dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Perturbation of protein thiol redox homeostasis has been shown to play a role in the dysregulation of cell death and
Aditi Verma +7 more
semanticscholar +4 more sources
Glutaredoxin 1 is a major player in copper metabolism in neuroblastoma cells
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014 Glutaredoxin 1 (Grx1), a small protein belonging to the thioredoxin family, is involved in redox-regulation since it catalyzes the reduction of protein disulfides and that of mixed disulfides. It was reported to modulate active copper extrusion from cells, by affecting the function of the pumps ATP7A and B.
De Benedetto, M +6 more
openaire +5 more sources
The thioredoxin‐1 and glutathione/glutaredoxin‐1 systems redundantly fuel murine B‐cell development and responses [PDF]
European Journal of Immunology, 2019 Antioxidant systems maintain cellular redox homeostasis. The thioredoxin‐1 (Trx1) and the glutathione (GSH)/glutaredoxin‐1 (Grx1) systems are key players in preserving cytosolic redox balance.
Jonathan Muri +6 more
semanticscholar +3 more sources
Differential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesity. [PDF]
PLoS ONE, 2017 The onset and progression of diabetes mellitus type 2 is highly contingent on the amount of functional beta-cell mass. An underlying cause of beta-cell decay in diabetes is oxidative stress, which markedly affects the insulin producing pancreatic cells ...
Sebastian Friedrich Petry +3 more
doaj +2 more sources
PLoS ONE, 2015 The Chloride Intracellular Ion Channel (CLIC) family consists of six evolutionarily conserved proteins in humans. Members of this family are unusual, existing as both monomeric soluble proteins and as integral membrane proteins where they function as ...
Heba Al Khamici +11 more
doaj +2 more sources
Regulation of DJ-1 by Glutaredoxin 1 in Vivo: Implications for Parkinson's Disease. [PDF]
Biochemistry, 2016 Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, caused by the degeneration of the dopaminergic neurons in the substantia nigra. Mutations in PARK7 (DJ-1) result in early onset autosomal recessive PD, and oxidative modification of DJ-1 has been reported to regulate the protective activity of DJ-1 in vitro ...
Johnson WM +15 more
europepmc +4 more sources
Corrigendum to “Glutaredoxin 1 deficiency promotes intestinal epithelial cell copper toxicity in inflammatory bowel disease” [Redox Biology 93 (2026) 104164] [PDF]
Redox BiologyTiantian Zhang +11 more
doaj +2 more sources
Frontiers in Microbiology, 2023 The oxidizability of cysteine residues is exploited in redox chemistry and as a source of stabilizing disulfide bonds, but it also raises the possibility that these side chains will be oxidized when they should not be.
Stefanie S. Eben, James A. Imlay
doaj +1 more source
Evaluation of a dithiocarbamate derivative as an inhibitor of human glutaredoxin-1. [PDF]
J Enzyme Inhib Med Chem, 2013 Glutaredoxins (GRX) are involved in the regulation of thiol redox state. GRX-1 is a cytosolic enzyme responsible for the catalysis of deglutathionylation of proteins. To date, very few inhibitors of GRX-1 have been reported.The objective of this paper is to report 2-acetylamino-3-[4-(2-acetylamino-2-carboxyethyl-sulfanylthiocarbonylamino ...
Sadhu SS +4 more
europepmc +4 more sources
The FASEB Journal, 2023 Glutaredoxins (Grxs) are ubiquitous antioxidant proteins involved in many molecular processes to protect cells against oxidative damage. Here, we study the roles of Grxs in the pathogenicity of Toxoplasma gondii.
Ting-Ting Li +9 more
semanticscholar +1 more source