Results 191 to 200 of about 135,439,936 (222)

Contribution of glutaredoxin-1 to Fas s-glutathionylation and inflammation in ethanol-induced liver injury.

Life Science, 2020
AIMS The reversible protein S-glutathionylation (PSSG) modification of Fas augments apoptosis, which can be reversed by the cytosolic deglutathionylation enzyme glutaredoxin-1 (Grx1), but its roles in alcoholic liver injury remain unknown. Therefore, the
Xiao-Min Sun, Cui-Lian Ye, Qin Deng, Jing-Yu Chen, Chun-Bao Guo   +4 more
semanticscholar   +1 more source

Monocytic Glutaredoxin 1 Protects Mice against Obesity, Hyperglycemia and Atherosclerosis

Free Radical Biology and Medicine, 2016
We previously reported that glutaredoxin 1 (Grx1) protects monocytes from metabolic-stress induced priming, dysregulation and hypersensitization to chemokines. To address the role of monocytic Grx1 in mice and in the development of atherogenesis and obesity, we transplanted bone marrow (BM) from either wild-type (WT) or Grx1-/- (Grx1Leuko -/-) donor ...
Reto Asmis, Kevin Downs, Sina Tavakoli, John Short, Huynh Nga Nguyen   +4 more
openaire   +1 more source

Abstract 6012: Glutaredoxin-1 deficiency boosts intracellular glutathione to drive enhanced tumor survival in KRAS-mutant lung adenocarcinoma

Cancer Research
The antioxidant glutathione (GSH) is frequently elevated in KRAS-mutant lung adenocarcinoma (LUAD), suggesting a critical role of GSH in mitigating oxidative stress and promoting tumor growth.
R. Aboushousha, H. Abdelhamid, M. Newton, J. Warren, C. Erickson, M. MacPherson, Y. Janssen-Heininger   +6 more
semanticscholar   +1 more source

RETRACTED: Role of glutaredoxin-1 in cardioprotection: An insight with Glrx1 transgenic and knockout animals

Journal of Molecular and Cellular Cardiology, 2008
This study examined if glutaredoxin-1 (Glrx1), a redox-regulator of thioredoxin superfamily, plays any role in the redox signaling of ischemic myocardium. The hearts were subjected to 30 min of coronary occlusion followed by 24 h of reperfusion. Another group of hearts was rendered tolerant to ischemia (preconditioned, PC) by four cyclic episodes of 5 ...
Gautam, Malik, Norbert, Nagy, Ye-Shih, Ho, Nilanjana, Maulik, Dipak K, Das   +4 more
openaire   +2 more sources

Glutaredoxin 1 from big-belly seahorse (Hippocampus abdominalis): Molecular, transcriptional, and functional evidence in teleost immune responses.

Fish and Shellfish Immunology, 2019
Glutaredoxins (Grx) are redox enzymes conserved in viruses, eukaryotes, and prokaryotes. In this study, we characterized glutaredoxin 1 (HaGrx1) from big-belly seahorse, Hippocampus abdominalis.
W. Omeka, D. Liyanage, Thanthrige Thiunuwan Priyathilaka, G. Godahewa, Seongdo Lee, Sukkyoung Lee, Jehee Lee   +6 more
semanticscholar   +1 more source

The role of monocytic glutaredoxin 1 in atherogenesis.

Atherosclerosis, 2020
Y.J. Ahn, L. Wang, R. Asmis
openaire   +1 more source

Glutaredoxin 1 from Evolutionary Ancient Hydra: Characteristics of the Enzyme and Its Possible Functions in Cell

Biochemistry (Moscow), 2023
Nusrat Perween, Komal Pekhale, Gauri A. Haval, G. Bose, S. Mittal, S. Ghaskadbi, S. Ghaskadbi   +6 more
semanticscholar   +1 more source

Glutaredoxin 1 protects neurons from oxygen‐glucose deprivation/reoxygenation (OGD/R)-induced apoptosis and oxidative stress via the modulation of GSK-3β/Nrf2 signaling

Journal of Bioenergetics and Biomembranes, 2021
Zhengguo Qiu, Xu Li, Chong-Zhen Duan, Rui Li, Li-Feng Han   +4 more
semanticscholar   +1 more source

Glutaredoxin 1 And Protein S-Glutathionylation In COPD

C52. COPD PATHOGENESIS: HUMAN STUDIES, 2012
Niki Reynaert, Ine Kuipers, Jean-Louis Corhay, Juanita Vernooy, Renaud Louis, Emiel Wouters   +5 more
openaire   +1 more source

Glutaredoxin-1 Regulates Hepatic Lipid Metabolism

Free Radical Biology and Medicine, 2014
Di Shao, Jingyan Han, Jessica Bering, Chunxiang Yao, Xiuyun Hou, Richard Alan Cohen, Reiko Matsui, Markus Bachschmid   +7 more
openaire   +1 more source