Results 131 to 140 of about 3,189 (173)

Glutathione, Glutaredoxins, and Iron

Antioxidants & Redox Signaling, 2017
Glutathione (GSH) is the most abundant cellular low-molecular-weight thiol in the majority of organisms in all kingdoms of life. Therefore, functions of GSH and disturbed regulation of its concentration are associated with numerous physiological and pathological situations.
Carsten, Berndt, Christopher Horst, Lillig   +1 more
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Effect of peroxynitrite on glutaredoxin

Human & Experimental Toxicology, 2001
Glutaredoxin is an important enzyme in thiol homeostasis. As a thioltransferase, it reduces oxidized thiols. It also has dehydroascorbate reductase (DHAR) activity to reduce dehydroascorbate (DHA) to ascorbic acid. Peroxynitrite (ONOO - ) is one of the most active elements of oxidative stress
G, Aykaç-Toker, S, Bulgurcuoğlu, N, Koçak-Toker   +2 more
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The biological roles of glutaredoxins

Biochemical Journal, 2012
Grxs (glutaredoxins) are small ubiquitous redox enzymes. They are generally involved in the reduction of oxidative modifications using glutathione. Grxs are not only able to reduce protein disulfides and the low-molecular-mass antioxidant dehydroascorbate, but also represent the major enzyme class responsible for deglutathionylation reactions ...
Elke, Ströher, A Harvey, Millar
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Identification of Plant Glutaredoxin Targets

Antioxidants & Redox Signaling, 2005
Glutaredoxins (Grxs) are small ubiquitous proteins of the thioredoxin (Trx) family, which catalyze dithiol-disulfide exchange reactions or reduce protein-mixed glutathione disulfides. In plants, several Trx-interacting proteins have been isolated from different compartments, whereas very few Grx-interacting proteins are known.
Rouhier, Nicolas, Villarejo, Arsenio, Srivastava, Manoj, Gelhaye, Éric, Keech, Olivier, Droux, Michel, Finkemeier, Iris, Samuelsson, Göran, Dietz, Karl Josef, Jacquot, Jean-Pierre, Wingsle, Gunnar   +10 more
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Glutaredoxins in Thiol/Disulfide Exchange

Antioxidants & Redox Signaling, 2013
Glutaredoxins (Grxs) are small oxidoreductases of the thioredoxin family of proteins regulating the thiol redox state of several proteins. Thereby, Grxs are key elements in redox signaling.Redox signaling via protein thiols depends on reversible oxidative modifications induced mainly by reactive oxygen/nitrogen species and glutathione (GSH) in form of ...
Christopher Horst, Lillig, Carsten, Berndt   +1 more
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Mammalian glutaredoxin

1997
Abstract Mammalian glutaredoxin was first purified to homogeneity from calf thymus (Luthman et al., 1979; Luthman, Holmgren, 1982), which later enabled determination of the primary structure (Klintrot et al., 1984) demonstrating an active site with the sequence Cys-Pro-Tyr-Cys, identical to that of Escherichia coli glutaredoxin.
H Nakamura, F Aslund, A Holmgren
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Identification of novel targets of cyanobacterial glutaredoxin

Archives of Biochemistry and Biophysics, 2007
Glutaredoxins (Grxs) are small ubiquitous glutathione-disulfide oxidoreductase that reduce disulfide bonds of target proteins and maintain the redox homoeostasis of cells. Disruption of ssr2061 reduced the viability of cells indicated Grx2061 has a protective role against oxidative stress in Synechocystis sp. PCC 6803.
Min, Li, Qing, Yang, Lianwen, Zhang, Han, Li, Yunluan, Cui, Qingyu, Wu   +5 more
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Structure of the rice glutaredoxin (thioltransferase) gene

Gene, 1997
We have isolated the gene encoding a glutaredoxin in rice (Oryza sativa L.) and determined the nucleotide (nt) sequence of about a 4.2 kb long. The cloned gene (gRASC8) was found to contain four exons interrupted by three introns. The first exon begins the ATG translation start codon and the four exons code for a protein composed of 112 amino acids ...
S, Sha, T, Yabushita, K, Minakuchi, T, Masumura, K, Tanaka   +4 more
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Plasmodium falciparum glutaredoxin-like proteins

Biological Chemistry, 2005
Glutaredoxin-like proteins form a new subgroup of glutaredoxins with a serine replacing the second cysteine in the CxxC-motif of the active site. Yeast Grx5 is the only glutaredoxin-like protein studied biochemically so far. We identified and cloned three genes encoding glutaredoxin-like proteins from the malaria parasite Plasmodium falciparum (Pf Glp1,
Marcel, Deponte, Katja, Becker, Stefan, Rahlfs   +2 more
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Thioredoxin and Glutaredoxin

2007
The sections in this article are 1 Introduction 2 NMR of Escherichia coli Thioredoxin 3 NMR of Human Thioredoxin 4 NMR of Escherichia coli Glutaredoxin 5 Acknowledgements 6 Biographical Sketch Related ...
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