Results 41 to 50 of about 88,346 (287)

Antioxidants selenomethionine and D-pantethine differentially affect doxorubicin’s action on glutathione system in human leukemia cells varying in their resistance to chemotherapy in vitro

Біологічні студії, 2018
Rapid development of multiple drug resistance and occurrence of negative side effects in cancer patients arising at the treatment belong to the main problems in cancer chemotherapy.
Yu. S. Kozak, R. R. Panchuk, N. R. Skorokhyd, D. S. Semenovich, A. G. Moiseenok, R. S. Stoika   +5 more
doaj   +1 more source

Squid glutathione S-transferase. Relationships with other glutathione S-transferases and S-crystallins of cephalopods.

Journal of Biological Chemistry, 1993
Glutathione S-transferase (GST, EC 2.5.1.18) was purified from the digestive gland of the squid Ommastrephes sloani pacificus. It had high enzymatic activity for the 1-chloro-2,4-dinitrobenzene substrate and was composed of a major and a minor polypeptide band, both with molecular masses near 25 kDa on SDS-polyacrylamide gels.
R D Zinovieva, K Guo, Stanislav I. Tomarev, Joram Piatigorsky   +3 more
openaire   +3 more sources

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

A new member of Tau-class glutathione S-transferase from barley leaves [PDF]

, 2010
Glutathione S-transferase is a family of multifunctional detoxification enzymes which are mainly cytosolic that detoxify natural and exogenous toxic compounds by conjugation with glutathione.
Mohabatkar, Hassan, Mohsenzadeh, Sasan, Saffari, Babak   +2 more
core  

Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]

, 2007
G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung, Choi, Sangdun, Hwang, Jong-Ik, Ki, Sung Hwan, Kim, Sang Geon, Kim, Won Dong, Lee, Chang Ho   +6 more
core   +2 more sources

Increased serum homocysteine levels and glutathione-S-transferase activities in alcoholic patients attending de-addiction centre [PDF]

Саратовский научно-медицинский журнал, 2010
The purpose of this study was to investigate the effect of heavy alcohol consumption on serum Malondialdehyde, homocysteine status and glutathione-S -transferase (GST) activities in alcoholics consuming illicit liquor from lower socioeconomic background ...
Kulkarni S.R., Ravindra К.Р., Dhume С., Rataboli P.V., Rodrigues E., Rodrigues E.E.   +5 more
doaj  

Physiological and biochemical reactions of Hordeum vulgare seedlings to the action of silver nanoparticles

Vìsnik Dnìpropetrovsʹkogo Unìversitetu: Serìâ Bìologìâ, Ekologìâ, 2015
Morphometrical indexes, and spectrophotometrically measured protein and glutathione (GSH, GSSG) contents and activity of peroxidase (POD, EC 1.11.1.7), glutathione-reductase (GR, EC 1.6.4.2) and glutathione S-transferase (GST, EС 2.5.1.18) were examined ...
N. O. Khromykh, L. V. Shupranova, Y. V. Lykholat, V. S. Bil’chuk, V. S. Fedenko, L. V. Boguslavs’ka, O. I. Borysova   +6 more
doaj   +1 more source

Effect of Chronic Exposure to Pesticide Methomyl on Antioxidant Defense System in Testis of Tilapia (Oreochromis niloticus) and Its Recovery Pattern

Applied Sciences, 2021
The chronic effect of environmental methomyl on the antioxidant system in testis of Nile tilapia (Oreochromis niloticus) and its recovery pattern was investigated.
Shunlong Meng, Xi Chen, Chao Song, Limin Fan, Liping Qiu, Yao Zheng, Jiazhang Chen, Pao Xu   +7 more
doaj   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Isolation of glutathione-S- transferase inhibitors.

The Journal of Antibiotics, 1992
Daisuke Komagata, Ryûichi Sawa, Naoko Kinoshita, Chiaki Imada, TSUTOMU SAWA, HIROSHI NAGANAWA, MASA HAMADA, Yoshirō Okami, TOMIO TAKEUCHI   +8 more
openalex   +5 more sources