Results 61 to 70 of about 88,346 (287)
Frontiers in Molecular Biosciences, 2022 Cell transfection efficiency is still a limiting factor in gene function research. A method that allows isolation and enrichment of the transfection-positive cells is an effective solution. Here, we report a transfection-positive cell sorting system that
Shumin Ma +3 more
doaj +1 more source
A CMTM6 Nanobody Overcomes EGFR‐TKI Resistance in Non‐Small Cell Lung Cancer
Advanced Science, EarlyView.Overcoming EGFR‐TKI resistance remains a critical challenge in NSCLC treatment. This study identifies CMTM6 as a key regulator of EGFR stability and demonstrates that a novel anti‐CMTM6 nanobody disrupts the CMTM6‐EGFR interaction. Targeting CMTM6 restores EGFR degradation, suppresses tumor growth, and confers therapeutic benefit in both CDX and PDX ...
Lu Xia +18 more
wiley +1 more source
Glutathione-S-Transferase and Thiol Stress in patients with acute renal failure [PDF]
, 2010 Introduction: Tubular damage is common finding in acute renal failure (ARF). Various etiologies have been put forth to explain the tubular damage in ARF, one important mechanism among them is oxidative damage to renal tubules.
Attur, RP +5 more
core
Differential activities of glutathione s-transferase isoenzymes in strains of fasciola hepatica susceptible and resistant to triclabendazole [PDF]
, 2014 Fasciolosis, a parasitic zoonosis of intrahepatic location, is caused by the trematode Fasciola hepatica. Its control is mainly based on the use of the anthelminthic Triclabendazole (TCBZ).
Fernandez, Vanesa +3 more
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Induction of Glutathione S-transferase Activity in Triatoma infestans
Memorias do Instituto Oswaldo Cruz, 1997 Several synthetic pesticides and allelochemicals used to treat Triatoma infestans adults by topic application showed some degree of cytosolic glutathione S-transferase (GST) induction.
JL Sívori, N Casabé, EN Zerba, EJ Wood
doaj +1 more source
Advanced Science, EarlyView.These findings elucidate the innovative role of HIC1 as a transcriptional activator in GC, driving the initiation of pyroptosis and enhancing CD8+ T cell infiltration, which has certain novelty and creative significance. Collectively, targeting HIC1 can present an appealing immunotherapeutic strategy to improve outcomes in GC patients.
Mengjie Kang +4 more
wiley +1 more source
Epilepsia Open, EarlyView., 2022 Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica +6 more
wiley +1 more source
Zanco Journal of Pure and Applied Sciences, 2020 Chronic myeloid leukemia (CML) result from many reactions of heredity non-heredity factors. The null genotype for glutathione S-transferase (GSTM1 or GSTT1) is regarded a risk agent leukemia, especially on CML in various inhabitants.
Mukhlis H. Aali +4 more
doaj +3 more sources
Advanced Science, EarlyView.In this study, a novel mechanism is unveiled by which ADD1, acting as a molecular switch, coordinates actin branch dynamics and the transport of endocytic viruses and cargoes. Phosphorylation of ADD1 at Ser726 reduces actin branch density, enhancing endosome fusion and attachment to microtubules.
Meijun Jiang +10 more
wiley +1 more source
Glutathione S-transferase M1 (GSTM1) polymorphism in two Brazilian populations [PDF]
, 2000 A distribuição das freqüências fenotípicas do gene GSTM1 de duas amostras brasileiras, compostas de doadores sanguíneos de ambos os sexos com idade entre 18 e 61 anos, foi estudada.
Cabello, Pedro Hernan +3 more
core +2 more sources