Results 191 to 200 of about 986,817 (390)

TRIM56 Aggravates Cerebral Ischemia‐Reperfusion Injury via Inhibiting KLF4‐Activated Ferroptosis Signaling

Advanced Science, EarlyView.
This study reveals that the E3 ubiquitin ligase TRIM56 exacerbates neuronal ferroptosis and brain damage by mediating K48‐linked ubiquitination and degradation of KLF4, leading to suppression of the xCT/GSH/GPX4 axis. Targeting TRIM56 alleviates cerebral ischemia‐reperfusion injury in vivo and in vitro, highlighting its therapeutic potential.
Qiangping Wang, Shuang Li, Man Li, Wenke Zhou, Jianqing Zhang, Zhenfu Wu, Zhaoqi Mao, Juan Wan, Xinhao Tang, Baoping Zheng, Qiang Liu, Zhendong Li, Xiaobing Jiang, Qingping Wu, Youfan Ye, Haijun Wang   +15 more
wiley   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Redox State of Glutathione and Cysteine in Plasma Following Acute Stroke. [PDF]

Antioxidants (Basel)
McGinley C, Adeyemi O, Oyolola O, Ford BD, Ford GD.   +4 more
europepmc   +1 more source

Engineering Dimensional Configuration of Single‐Atom S‐Cu‐S Sites as Reversible Electron Station for Enhanced Peroxidase‐Mimicking

Advanced Science, EarlyView.
L‐cysteine triggers auto‐assembly of POD‐like 3D biomimetic S‐Cu‐S single‐atom nanozymes on MoS2 (MoCC). MoCC shows 16.3‐fold higher catalytic velocity and 17.9‐fold greater affinity than HRP, enabling efficient •OH generation via enhanced electron inversion and transfer.
Wenjie Ma, Qian He, Jiancheng Sun, Yiqing Chen, Hongfei Su, Ludan Zhang, Xiao He, Yuguang Wang, Changjian Xie, Zhiyong Zhang, Xin Zhou, Yuliang Zhao, Wenyan Yin   +12 more
wiley   +1 more source

The Effects of Reduced Glutathione on Growth Performance, Intestinal Inflammation, and Gut Microbiota in Immune-Stressed Broiler Chickens. [PDF]

Animals (Basel)
Wang XQ, Zhang T, Liu YK, Li HJ, Makatjane KA, Lai Z, Bi JX, Zhou HZ, Guo W.   +8 more
europepmc   +1 more source

Alteration of Glutathione and Antioxidant Status with Exercise in Unfed and Refed Rats

, 1996
Christiaan Leeuwenburgh, Li Li Ji
openalex   +1 more source

The Glutathione Transferase Structural Family Includes a Nuclear Chloride Channel and a Ryanodine Receptor Calcium Release Channel Modulator [PDF]

, 2001
Angela F. Dulhunty, Peter W. Gage, Suzanne M. Curtis, Gareth Chelvanayagam, Philip G. Board   +4 more
openalex   +1 more source

Differences in the effects of sodium selenate and sodium selenite on the mortality, reproduction, lipid peroxidation and glutathione redox status of Folsomia candida Willem 1902 (Collembola)

, 2021
Benjamin Bálint, Krisztián Balogh, Miklós Mézes, Borbála Szabó   +3 more
openalex   +1 more source

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

Advanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang   +11 more
wiley   +1 more source

Reduced glutathione levels in <i>Enterococcus faecalis</i> trigger metabolic and transcriptional compensatory adjustments during iron exposure. [PDF]

mSystems
Aliaga-Tobar V, Torres J, Mendoza SN, Gálvez G, Ortega J, Gómez S, Parra V, Arenas F, Maass A, Siegel A, González M, Latorre M.   +11 more
europepmc   +1 more source