Results 191 to 200 of about 80,205 (222)

A Copper‐Based Photothermal‐Responsive Nanoplatform Reprograms Tumor Immunogenicity via Self‐Amplified Cuproptosis for Synergistic Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This study introduces cuproptosis nanoplatform, a novel nanoplatform using Cu2−XS hollow nanospheres, elesclomol, and lauric acid (LA) for self‐amplified cuproptosis. NIR‐II laser activation melts LA, releasing copper ions and elesclomol to enhance copper delivery within tumor cells, reduce glutathione's inhibitory effect, and trigger immunogenic cell ...
Runzi Cheng   +10 more
wiley   +1 more source

THE COLORIMETRIC ESTIMATION OF CYSTINE AND GLUTATHIONE

open access: hybrid, 1927
George Hunter, Blythe Alfred Eagles
openalex   +1 more source

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

open access: yesAdvanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian   +5 more
wiley   +1 more source

Hypothalamus Regulates Anabolic Metabolism of Articular Cartilage Superficial Chondrocytes through PGE2 Skeletal Interoception

open access: yesAdvanced Science, EarlyView.
Hypothalamus sympathetic norepinephrine inhibits regeneration of articular cartilage. Mechanical loading on bone during animal activity elevates PGE2 skeletal interoception to promote an anabolic renewal of the superficial membrane by downregulation of norepinephrine for articular cartilage proper thickness and integrity.
Ziyi Wang   +8 more
wiley   +1 more source

PDCD11 Stabilizes C‐MYC Oncoprotein by Hindering C‐MYC‐SKP2 Negative Feedback Loop to Facilitate Progression of p53‐Mutant Breast and Colon Malignancies

open access: yesAdvanced Science, EarlyView.
PDCD11 overexpression highly correlates to poor prognosis in p53‐mutant breast and colon cancers. Through interaction with C‐MYC in the nucleoplasm, PDCD11 hinders C‐MYC‐induced SKP2 from binding to the C‐MYC MB2 domain for ubiquitination, thereby stabilizing C‐MYC to drive tumor progression.
Li Ding   +12 more
wiley   +1 more source

Polarography of Glutathione

open access: bronze, 1951
Isamu Tachi   +2 more
openalex   +2 more sources

Artificial Intelligent‐Enhanced Metabolite Profiling for Intraoperative IDH1 Genotyping in Glioma Using an Orthogonally Responsive SERS Probe

open access: yesAdvanced Science, EarlyView.
This study presents a novel approach for intraoperative identification of the IDH1 genotype in glioma patients using a surface‐enhanced Raman scattering (SERS) probe to measure glutathione and hydrogen peroxide. By integrating AI‐driven deep learning algorithms, the method achieves rapid and accurate genotype differentiation, offering the potential to ...
Hang Yin   +14 more
wiley   +1 more source

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