Results 131 to 140 of about 77,313 (353)

Modulation of Lanthanide Luminescence with the Mechanical Bond: Antenna‐Emitter Confinement in a Compact [2]Rotaxane

Angewandte Chemie International Edition, Accepted Article.
Luminescent emitters based on lanthanide ions are of ubiquitous importance in the biological sciences, but typically need sensitisation from a covalently attached adjacent chromophore – an “antenna” – to have suitable emission intensities. Here we show that the mechanical bond can be used to connect the antenna to the emitter, providing unique dynamic ...
Anja Ramström, Daisy R. S. Pooler, Huseynagha Abasov, Monika Tomar, Stefano Crespi, Fredrik Schaufelberger   +5 more
wiley   +1 more source

Measurement and clinical significance of biomarkers of oxidative stress in humans [PDF]

, 2017
Oxidative stress is the result of the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidants. Biomarkers of oxidative stress are relevant in the evaluation of the disease status and of the health-enhancing ...
Altieri, Fabio, Marrocco, Ilaria, Peluso, Ilaria   +2 more
core   +3 more sources

Intracellular Delivery of Native Proteins by BioReversible Arginine Modification (BioRAM) on Amino Groups

Angewandte Chemie International Edition, Accepted Article.
Protein‐based tools are emerging as innovative solutions to interfere with biological pathways in molecular biology and medicine. They offer advantages over traditional small molecules due to their adaptable structural diversity and their ability to engage previously inaccessible cellular targets.
Jonathan Franke, Jan Vincent V. Arafiles, Leis Christian, Christian Hackenberger   +3 more
wiley   +1 more source

Fluorinated branched polymer enables Ce6 and IR780 more effective for phototherapy

Nano Select, EarlyView., 2021
Hydrophobic IR780 and Ce6 were loaded into fluorinated polymer micelles by self‐assembly, and they showed good photodynamic and photothemal abilities, enabling them to synergistically induce tumor cell apoptosis. Abstract Phototherapy is gradually becoming a primary technique for treating tumors due to increased efficacy and less side effects.
Chenglong Mu, Xiaodan Sun, Kai Yan
wiley   +1 more source

Nimesulide limits kainate-induced oxidative damage in the rat hippocampus [PDF]

European Journal of Pharmacology 390(3): 295-298 (2000), 2007
Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus.
arxiv  

X‐ray controlled release strategy in cancer therapy

BMEMat, EarlyView.
A comprehensive review on the design principles and current strategies of X‐ray stimulated release systems in cancer therapy, focusing on the X‐ray responsive functional groups and materials as well as discussing the advantages and current challenges of X‐ray controlled release systems in cancer therapy.
Yiling Ruan, Hongxiang Huang, Huihui Liu, Jinglang Gong, Changjun Li, Xiaolian Sun   +5 more
wiley   +1 more source

Iron (II)-based metal-organic framework nanozyme for boosting tumor ferroptosis through inhibiting DNA damage repair and system Xc -

Journal of Nanobiotechnology
Development of ferroptosis-inducible nanoplatforms with high efficiency and specificity is highly needed and challenging in tumor ferrotherapy. Here, we demonstrate highly effective tumor ferrotherapy using iron (II)-based metal-organic framework ...
Panpan Xue, Huilan Zhuang, Tingjie Bai, Xuemei Zeng, Jinpeng Deng, Sijie Shao, Shuangqian Yan   +6 more
doaj   +1 more source

Nanostructured drug delivery systems for posterior segment eye diseases: Strategies to defy ocular barriers

BMEMat, EarlyView.
Efficient drug delivery to the posterior segment of the eye has long been a challenging issue due to the complex ocular barriers. The review focuses on the promise held by nanoplatforms for barrier penetration and the key mechanisms involved, also highlighting their advantages in achieving efficient drug delivery and superior treatment of PSEDs ...
Yifan Shen, Ying Yao, Yan Zhang, Xinyu Shi, Ling Bai, Yang Zhong, Yan Zhang, Kun Zhang   +7 more
wiley   +1 more source

“Pincer movement”: Reversing cisplatin resistance based on simultaneous glutathione depletion and glutathione S-transferases inhibition by redox-responsive degradable organosilica hybrid nanoparticles

Acta Pharmaceutica Sinica B, 2022
The therapeutic efficacy of cisplatin has been restricted by drug resistance of cancers. Intracellular glutathione (GSH) detoxification of cisplatin under the catalysis of glutathione S-transferases (GST) plays important roles in the development of ...
Boyi Niu, Yixian Zhou, Kaixin Liao, Ting Wen, Sixian Lao, Guilan Quan, Xin Pan, Chuanbin Wu   +7 more
doaj  

Robust Retrospective Frequency and Phase Correction for Single-voxel MR Spectroscopy [PDF]

arXiv, 2018
Purpose: subject motion and static field (B$_0$) drift are known to reduce the quality of single voxel MR spectroscopy data due to incoherent averaging. Retrospective correction has previously been shown to improve data quality by adjusting the phase and frequency offset of each average to match a reference spectrum.
arxiv