Results 161 to 170 of about 77,313 (353)

RGC1/RGC2 deletions cause increased sensitivity to oxidative stress in Saccharomyces cerevisiae, which can be overcome by constitutive nuclear Yap1 expression [PDF]

open access: yes, 2016
Oxidative stress mechanism in yeast presents an innovative pathway to understand in creating the next generation of antifungal drugs. Rgc1 and Rgc2 are paralogous proteins that regulate the Fps1 glycerol channel in hyperosmotic stress.
Tsai, Michelle
core   +1 more source

Fisetin as a Blueprint for Senotherapeutic Agents – Elucidating Geroprotective and Senolytic Properties with Molecular Modeling

open access: yesChemistry – A European Journal, Volume 31, Issue 16, March 17, 2025.
The exceptional senotherapeutic activity of fisetin, combining both geroprotective and senolytic effects, was validated using computational chemistry tools, establishing it as a cornerstone template for the development of novel agents. Abstract Targeting senescent cells and the factors that accelerate this pathological state has recently emerged as a ...
Maciej Spiegel
wiley   +1 more source

circAMN1-Mediated Ferroptosis Regulates the Expulsion of Placenta in Trophoblast Cells

open access: yesAntioxidants
After delivery, the death of trophoblast cells can promote the expulsion of the placenta. Ferroptosis, an iron-dependent programmed cell death, is involved in mammalian development.
Chen Lv   +5 more
doaj   +1 more source

Size‐Dependent Ultrafast UV Photochemistry of Aliphatic Disulfides in Solution

open access: yesChemistry – A European Journal, EarlyView.
Aliphatic disulfides exclusively split homolytically along the S−S bond when directly exciting the disulfide chromophore at about 250 nm. Ultrafast (<1 ps) geminate recombination at high yield is observed in solution for fragment sizes as small as L‐cysteine. The smallest disulfide recombines ten‐fold more slowly.
Jessica Harich   +14 more
wiley   +1 more source

Chirality in Transition Metal Dichalcogenide Nanostructures

open access: yesChemistry – A European Journal, EarlyView.
The emergence of chirality in inorganic nanostructures has a critical impact on the properties and potential applications of these novel nanomaterials. This work presents a critical collection of examples of the observation of chirality in TMDs, covering different synthetic procedures and origins of chirality as well as a broad range of dimensionality ...
Lorenzo Branzi   +3 more
wiley   +1 more source

Oxidative Folding of a Two‐Chain Protein Having Three Interchain Disulfide Bonds. Synthesis of Bromelain Inhibitor VI Through Native Chain Assembly

open access: yesChemistry – A European Journal, EarlyView.
Bromelain inhibitor VI, a two‐chain protein stabilized by three interchain SS bonds and two intrachain SS bonds, was synthesized in an incredibly high isolated yield (53%) just by mixing the two native chains in a buffer solution. This success made a record of oxidative protein folding for the most complicated and difficult one.
Michio Iwaoka, Sawa Akaboshi
wiley   +1 more source

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