Results 61 to 70 of about 48,461 (279)

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, EarlyView.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

Potential role of glutathione in evolution of thiol-based redox signaling sites in proteins

Frontiers in Pharmacology, 2015
Cysteine is susceptible to a variety of modifications by reactive oxygen and nitrogen oxide species, including glutathionylation; and when two cysteines are involved, disulfide formation.
Kaavya A Mohanasundaram, Naomi L Haworth, Mani P Grover, Tamsyn M Crowley, Tamsyn M Crowley, Andrzej eGoscinski, Merridee Ann Wouters   +6 more
doaj   +1 more source

A Bioorthogonally Synthesized and Disulfide-Containing Fluorescence Turn-On Chemical Probe for Measurements of Butyrylcholinesterase Activity and Inhibition in the Presence of Physiological Glutathione [PDF]

, 2020
Ming-Mao Gong, Chia‐Yen Dai, Scott Severance, Chi‐Ching Hwang, Bo-Kai Fang, Heng-Bo Lin, Chien-Hui Huang, Chi Wi Ong, Jeh‐Jeng Wang, Pei‐Lun Lee, Tzu-Pin Wang   +10 more
openalex   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Magnesium Structure‐Function Integration Platform for Spatiotemporal Multi‐Modality Therapy: Combining Hormonotherapy and Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
The schematic illustration of the MHSCG platform for spatiotemporal responsive GRb1 release to induce androgen deprivation therapy (ADT) and immunogenic cell death (ICD) multimodal therapy in prostate cancer. Abstract Metal‐based immunotherapy represents a promising strategy for enhancing antitumor efficacy; however, its clinical application is limited
Rui Zan, Qianping Mao, Keyi Wang, Guodong Zou, Shi Yang, Hua Qiu, Xiang Fang, Guiqing Wang, Xinyi Zhou, Jiexia Wen, Shuai Jiang, Ran Huang, Qiuming Peng, Tao Suo   +13 more
wiley   +1 more source

The Oxidized Protein Repair Enzymes Methionine Sulfoxide Reductases and Their Roles in Protecting against Oxidative Stress, in Ageing and in Regulating Protein Function

Antioxidants, 2018
Cysteine and methionine residues are the amino acids most sensitive to oxidation by reactive oxygen species. However, in contrast to other amino acids, certain cysteine and methionine oxidation products can be reduced within proteins by dedicated ...
Sofia Lourenço dos Santos, Isabelle Petropoulos, Bertrand Friguet   +2 more
doaj   +1 more source

Photocatalytically Activated Cu‐N1S3 Single‐Atom Nanozyme: Enhancing Enzyme Activities and Antibacterial Synergy for Highly Efficient Fruit Preservation

Advanced Science, EarlyView.
This study presents S‐coordinated Cu single‐atom nanozymes (Cu/CNS) fabricated via mild photocatalytic self‐assembly strategy. The nanozyme exhibits exceptional multi‐enzyme activity and near‐perfect antimicrobial efficacy. Incorporated into chitosan‐gelatin film, it enables pH‐responsive, broad‐spectrum fruit preservation, more than doubling the shelf‐
Chuanlong Men, Chenchen Wu, Lei Wang, Shengjie Gao, Yu Mao, Wei Liu, Changhong Liu, Lei Zheng   +7 more
wiley   +1 more source

Assessment of Serum Dynamic Thiol/Disulfide Homeostasis and Oxidative/Nitrosative Stress in Patients with Crohn’s Disease

The Turkish Journal of Gastroenterology
Background/Aims: Crohn’s disease (CD) is a major subtype of chronic relapsing inflammatory gastrointestinal disorders. In this study, we assessed the possible contributions of serum oxidative/nitrosative stress and dynamic thiol/disulfide homeostasis to ...
Ancel Aysun Bağdaş, Sezgin Barutçu, Ahmet Saracaloğlu, Abdullah Tuncay Demiryürek   +3 more
doaj   +1 more source

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Differential expression of disulfide reductase enzymes in a free-living platyhelminth (Dugesia dorotocephala).

PLoS ONE, 2017
A search of the disulfide reductase activities expressed in the adult stage of the free-living platyhelminth Dugesia dorotocephala was carried out. Using GSSG or DTNB as substrates, it was possible to obtain a purified fraction containing both GSSG and ...
Alberto Guevara-Flores, Álvaro Miguel Herrera-Juárez, José de Jesús Martínez-González, Irene Patricia Del Arenal Mena, Óscar Flores-Herrera, Juan Luis Rendón   +5 more
doaj   +1 more source