Results 31 to 40 of about 487,455 (339)
Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy
Frontiers in Pharmacology, 2018 The anti-oxidative enzyme, glutathione peroxidase 4 (GPX4), helps to promote inflammation resolution by eliminating oxidative species produced by the arachidonic acid (AA) metabolic network.
Cong Li +5 more
semanticscholar +1 more source
Antioxidant nanozyme counteracts HIV‐1 by modulating intracellular redox potential
EMBO Molecular Medicine, 2021 Reactive oxygen species (ROS) regulates the replication of human immunodeficiency virus (HIV‐1) during infection. However, the application of this knowledge to develop therapeutic strategies remained unsuccessful due to the harmful consequences of ...
Shalini Singh +7 more
doaj +1 more source
Біологічні студії, 2016 The activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, the content of reduced glutathione and products of lipid peroxidation in liver tissue of rats with alloxan-indused diabetes were investigated.
O. Shatynska, R. Iskra
doaj +1 more source
The effects of hyperthyroidism on lipid peroxidation, erythrocyte glutathione and glutathione peroxidase [PDF]
Journal of Medical Biochemistry, 2011 The aim of this study was to determine if lipid per o xidation, glutathione, and glutathione peroxidase levels can be effected by hyperthyroidism. Twenty-three subjects with hyper thy roidism (18 females/5 males), and 19 euthyroid subjects (11 females/8 ...
Ali Abusrie Abdellah, Sultan Phalisteen
doaj
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Медицинский вестник Юга России, 2015 Purpose: to research the glutathione system state in rat tissues after trauma of the musculoskeletal system in a methionineinduced hyperhomocysteinemia.Materials and methods: the level of homocysteine in the plasma of animals, as well as the amount of ...
I. A. Alliluev +6 more
doaj +1 more source
Molecular Oncology, EarlyView.In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella +18 more
wiley +1 more source
Effects of Various Drugs on Alcohol-induced Oxidative Stress in the Liver
Molecules, 2008 The major aim of this work was to investigate how alcohol-induced oxidative stress in combined chemotherapy changes the metabolic function of the liver in experimental animals.
Svetlana Trivic +4 more
doaj +1 more source
Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors.
Blood, 2016 Maintaining cellular redox balance is vital for cell survival and tissue homoeostasis because imbalanced production of reactive oxygen species (ROS) may lead to oxidative stress and cell death.
Özge Canlı +9 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source