Results 31 to 40 of about 508,182 (337)

Glutathione metabolism system under condition of transplantation of muscle tissue in rats

Regulatory Mechanisms in Biosystems, 2015
The paper presents the results of determining the amount of reduced glutathione, glutathione reductase and glutathione peroxidase activity at transplantation of muscle tissue taken from rats from the same litter.
O. V. Kulibaba, S. M. Kozishkurt, O. O. Duzenko, I. L. Vovchuk, S. A. Petrov   +4 more
doaj   +1 more source

Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy

Frontiers in Pharmacology, 2018
The anti-oxidative enzyme, glutathione peroxidase 4 (GPX4), helps to promote inflammation resolution by eliminating oxidative species produced by the arachidonic acid (AA) metabolic network.
Cong Li, Xiaobing Deng, Xiaowen Xie, Y. Liu, José Pedro Friedmann Angeli, L. Lai   +5 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

The effect of magnesium citrates on pro-oxidative/antioxidative status in rat liver at experimental diabetes

Біологічні студії, 2016
The activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, the content of reduced glutathione and products of lipid peroxidation in liver tissue of rats with alloxan-indused diabetes were investigated.
O. Shatynska, R. Iskra
doaj   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

The effects of hyperthyroidism on lipid peroxidation, erythrocyte glutathione and glutathione peroxidase [PDF]

Journal of Medical Biochemistry, 2011
The aim of this study was to determine if lipid per o xidation, glutathione, and glutathione peroxidase levels can be effected by hyperthyroidism. Twenty-three subjects with hyper thy roidism (18 females/5 males), and 19 euthyroid subjects (11 females/8 ...
Ali Abusrie Abdellah, Sultan Phalisteen
doaj  

THE STATE OF GLUTATHIONE SYSTEM IN RAT TISSUES WITH TRAUMA MUSCULOSKELETAL SYSTEM IN THE METHIONINE INDUCED HYPERHOMOCYSTEINEMIA

Медицинский вестник Юга России, 2015
Purpose: to research the glutathione system state in rat tissues after trauma of the musculoskeletal system in a methionineinduced hyperhomocysteinemia.Materials and methods: the level of homocysteine in the plasma of animals, as well as the amount of ...
I. A. Alliluev, E. M. Vechkanov, I. A. Sorokina, Ju. N. Kaljuzhnaja, A. V. Temjakov, I. I. Kuznecov, V. V. Vnukov   +6 more
doaj   +1 more source

Otoprotection Mechanisms Against Oxidative Stress Caused by Cisplatin

International Archives of Otorhinolaryngology, 2020
Introduction Cisplatin damages the auditory system and is related to the generation of free radicals. Glutathione peroxidase is an endogenous free radicals remover.
Maiara Santos Gonçalves, Aron Ferreira da Silveira, Adriana de Andrade Batista Murashima, Maria Rossato, Miguel Angelo Hippolito   +4 more
doaj   +1 more source

Glutathione peroxidases as oncotargets

Oncotarget, 2017
Oxidative stress is a disturbance in the equilibrium among free radicals, reactive oxygen species, and endogenous antioxidant defense mechanisms. Oxidative stress is a result of imbalance between the production of reactive oxygen and the biological system's ability to detoxify the reactive intermediates or to repair the resulting damage.
Jiao, Yang, Wang, Yirong, Guo, Shanchun, Wang, Guangdi   +3 more
openaire   +3 more sources