Glutathione peroxidase 4 overexpression induces anomalous subdiffusion and impairs glioblastoma cell growth [PDF]
Journal of Biological EngineeringGlioblastoma tumors are the most common and aggressive adult central nervous system malignancy. Nearly all patients experience disease progression, which significantly contributes to disease mortality.
Nahom Teferi +6 more
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The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities [PDF]
Biomedicines, 2022 The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators in the human body. Its central function involves the reduction of complex hydroperoxides into their respective alcohols often using reduced Glutathione (GSH) as a ...
Kamari Weaver, Rachid Skouta
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Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells [PDF]
Frontiers in Oncology, 2022 BackgroundDespite the effectiveness of chemotherapy and targeted therapy for colorectal cancer, drug resistance drives therapy failure and tumor relapse.
Xiaoli Zhang +8 more
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Curcumin nanocrystals ameliorate ferroptosis of diabetic nephropathy through glutathione peroxidase 4 [PDF]
Frontiers in PharmacologyObjectiveThe aim of this study was to investigate the effect of curcumin nanocrystals (Cur-NCs) on ferroptosis in high-glucose (HG)-induced HK-2 cells and streptozotocin (STZ)-induced diabetic nephropathy model (DN) rats.
Mengjiao Xue +9 more
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Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer’s disease [PDF]
Neural Regeneration ResearchAlzheimer’s disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer’s disease has not yet been found.
Yanxin Shen +6 more
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Evaluation of urine glutathione peroxidase 4 in cats with chronic kidney disease [PDF]
Frontiers in Veterinary ScienceIntroductionFerroptosis is a distinct form of regulated cell death characterized by iron-dependent lipid peroxidation that damages cellular membranes and leads to the end of a cell’s life.
Wei-Li Hsu +6 more
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Correlation of ferritin and glutathione peroxidase 4 (GPX4) level as a marker of ferroptosis process in endometrioma [PDF]
Scientific ReportsEndometriosis is a chronic inflammatory disease characterized by the presence of endometrial-like tissues (glands and stroma) located outside the uterine cavity. The pathophysiology of this condition remains incompletely understood.
Rina Nulianti +8 more
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Midbrain dopamine oxidation links ubiquitination of glutathione peroxidase 4 to ferroptosis of dopaminergic neurons [PDF]
The Journal of Clinical Investigation, 2023 Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the gradual loss of midbrain dopaminergic neurons in association with aggregation of α-synuclein. Oxidative damage has been widely implicated in this disease, though the mechanisms
Jie Sun +21 more
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Glutathione peroxidase 4 as an emerging therapeutic target in osteoarthritis: focus on ferroptosis [PDF]
Frontiers in Cell and Developmental BiologyOsteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation, extracellular matrix breakdown, low-grade chronic inflammation, and pain. Its etiology is complex and treatment options are limited.
Lin Zhang +3 more
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Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer [PDF]
Scientific Reports, 2022 Papillary thyroid carcinoma (PTC) demonstrates significantly reduced patient survival with metastatic progression. Tumor progression can be influenced by metabolism, including antioxidant glutathione (GSH).
Konjeti R. Sekhar +7 more
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