Therapeutic approach of glutathione/glutathione peroxidase-4 axis modulation in the light of ferroptosis [PDF]
Pharmacia, 2022 In the 21st century beginning, the evidence of a new type of programmed cell death, different from apoptosis, began to accumulate. In 2012, the ferroptosis concept was officially introduced.
Tsvetelin Georgiev +7 more
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Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration
Redox Biology, 2016 The selenoenzyme glutathione peroxidase 4 (Gpx4) is an essential mammalian glutathione peroxidase, which protects cells against detrimental lipid peroxidation and governs a novel form of regulated necrotic cell death, called ferroptosis.
Bradley A. Carlson +8 more
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Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy [PDF]
Frontiers in Pharmacology, 2018 The anti-oxidative enzyme, glutathione peroxidase 4 (GPX4), helps to promote inflammation resolution by eliminating oxidative species produced by the arachidonic acid (AA) metabolic network.
Cong Li +8 more
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Role of Glutathione Peroxidase 4 in Glutamate-Induced Oxytosis in the Retina. [PDF]
PLoS ONE, 2015 The purpose of the present study was to investigate the role of glutathione peroxidase 4 (GPx4) in glutamate-induced oxytosis in the retina.For in vitro studies, an immortalized rat retinal precursor cell line R28 was used.
Osamu Sakai +5 more
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Glutathione peroxidase 4 expression predicts poor overall survival in patients with resected lung adenocarcinoma [PDF]
Scientific Reports, 2022 This study aimed to evaluate the protein expression of glutathione peroxidase 4 (GPX4) in resected non-small cell lung cancer (NSCLC). The clinical relevance and prognostic significance of GPX4 expression were analyzed. We reviewed patients with resected
Chao-Yu Liu +6 more
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Functional Deficits of 5×FAD Neural Stem Cells Are Ameliorated by Glutathione Peroxidase 4 [PDF]
Cells, 2022 Alzheimer’s disease (AD) is the most common cause of dementia affecting millions of people around the globe. Impaired neurogenesis is reported in AD as well as in AD animal models, although the underlying mechanism remains unclear.
Nawab John Dar, Ren Na, Qitao Ran
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Glutathione peroxidase 4 as a potential biomarker for atrial fibrosis and recurrence of atrial fibrillation [PDF]
Heart Rhythm O2Background: Atrial fibrosis mediates the development and maintenance of atrial fibrillation (AF). Glutathione peroxidase 4 (GPX4) is a ferroptosis biomarker.
Tong Liu, MD +10 more
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Inhibition of glutathione peroxidase 4 suppresses gastric cancer peritoneal metastasis via regulation of RCC2 homeostasis [PDF]
Redox BiologyGastric cancer (GC) is one of the most lethal malignancies due to high metastatic rate, making the identification of new therapeutic targets critical for developing effective anti-GC treatments.
Can Hu +15 more
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Glutathione peroxidase 8 negatively regulates caspase‐4/11 to protect against colitis [PDF]
EMBO Molecular Medicine, 2019 Human caspase‐4 and its mouse homolog caspase‐11 are receptors for cytoplasmic lipopolysaccharide. Activation of the caspase‐4/11‐dependent NLRP3 inflammasome is required for innate defense and endotoxic shock, but how caspase‐4/11 is modulated remains ...
Jye‐Lin Hsu +9 more
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Emerging role of glutathione peroxidase 4 in myeloid cell lineage development and acute myeloid leukemia [PDF]
Cellular & Molecular Biology LettersPhospholipid Hydroperoxide Gluthatione Peroxidase also called Glutathione Peroxidase 4 is one of the 25 described human selenoproteins. It plays an essential role in eliminating toxic lipid hydroxy peroxides, thus inhibiting ferroptosis and favoring cell
Patrick Auberger +4 more
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