Results 21 to 30 of about 240,067 (266)

Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity. [PDF]

Nat Immunol, 2021
The linkage between neutrophil death and the development of autoimmunity has not been thoroughly explored. Here, we show that neutrophils from either lupus-prone mice or patients with systemic lupus erythematosus (SLE) undergo ferroptosis. Mechanistically, autoantibodies and interferon-α present in the serum induce neutrophil ferroptosis through ...
Li P, Jiang M, Li K, Li H, Zhou Y, Xiao X, Xu Y, Krishfield S, Lipsky PE, Tsokos GC, Zhang X.   +10 more
europepmc   +4 more sources

Modulation of sarcopenia phenotypes by glutathione peroxidase 4 overexpression in mice. [PDF]

J Physiol, 2023
AbstractOur laboratory previously showed lipid hydroperoxides and oxylipin levels are elevated in response to loss of skeletal muscle innervation and are associated with muscle pathologies. To elucidate the pathological impact of lipid hydroperoxides, we overexpressed glutathione peroxidase 4 (GPx4), an enzyme that targets reduction of lipid ...
Xu H, Czyżowska A, Van Remmen H, Brown JL.   +3 more
europepmc   +3 more sources

Long-term results of the enzyme glutation system activity in experimental ovarian cancer

Journal of Education, Health and Sport, 2022
The article presents the experimental results of the investigation the glutathione system activity (glutathione peroxidase and glutathione reductase) in rats simulated ovarian ascites tumor.
L. Yershova, R. Yeromenko, I. Savytskyi, T. Alexandryna, L. Sarakhan   +4 more
doaj   +1 more source

Evaluation of Glutathione Peroxidase 4 role in Preeclampsia [PDF]

Scientific Reports, 2016
AbstractPreeclampsia (PE) is a pregnancy-specific syndrome that may be lifethreatening to pregnancies and fetus. Glutathione Peroxidase 4 (GPx4) is a powerful antioxidant enzyme that can provide protection from oxidative stress damage which plays a pivotal role in the pathology of PE.
Xinguo Peng, Yan Lin, Jinling Li, Mengchun Liu, Jingli Wang, Xueying Li, Jingjing Liu, Xuewen Jia, Zhongcui Jing, Zuzhou Huang, Kaiqiu Chu, Shiguo Liu   +11 more
openaire   +5 more sources

Multifaceted role of ferroptosis in cardiovascular disease

Acta Biochimica et Biophysica Sinica, 2023
Ferroptosis is a newly identified form of non-apoptotic cell death characterised primarily by iron-dependent lipid peroxidation. It differs morphologically, biochemically, and genetically from other forms of cell death, such as apoptosis, autophagy, and ...
Li Chengyi, Zhu Xiusong, Chen Juxian, Xie Xiaoxi, Liang Sijia, Liu Xiu, Gong Quan, Guo Jiawei   +7 more
doaj   +1 more source

Glutathione peroxidase 4 restrains temporomandibular joint osteoarthritis progression by inhibiting ferroptosis. [PDF]

J Cell Mol Med
AbstractThere are few effective therapeutic strategies for temporomandibular joint osteoarthritis (TMJOA) due to the unclear pathology and mechanisms. We aimed to confirm the roles of GPX4 and ferroptosis in TMJOA progression. ELISA assay was hired to evaluate concentrations of ferroptosis‐related markers.
Pang C, Zhang H, Liu Y, Tang N, Tian K, Mu Y, Li X, Xiao L.   +7 more
europepmc   +3 more sources

Protective role of glutathione peroxidase 4 in laser-induced choroidal neovascularization in mice. [PDF]

PLoS ONE, 2014
PURPOSE: To evaluate the influence of glutathione peroxidase 4 (GPx4) expression in retinal pigment epithelium (RPE)/choroid tissue using a mouse model of laser-induced choroidal neovascularization (CNV).
Murilo Felix Roggia, Hirotaka Imai, Tomoyasu Shiraya, Yasuo Noda, Takashi Ueta   +4 more
doaj   +1 more source

The Impact of Passive Smoking on Salivary Glutathione Peroxidase and Selenium in Relation to Dental Caries Severity among Five Years Old Children

Indian Journal of Dental Research, 2023
Background: It had been found that passive smoking may have the same harmful effect as tobacco cigarettes smoking. Aims: This study was conducted to determine the effect of passive smoking on salivary glutathione peroxidase and selenium in relation to ...
Shahba’a Munther, Baydaa Hussain Awn, Hiba N. Yassin   +2 more
doaj   +1 more source

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors [PDF]

Blood, 2016
Key Points Gpx4 is essential for preventing anemia in mice via inhibiting RIP3-dependent necroptosis in erythroid precursor cells. ROS accumulation and lipid peroxidation in erythroid precursor cells trigger receptor-independent activation of necroptosis.
Canli, Ö., Alankus, Y.B., Grootjans, S., Vegi, N., Hültner, L., Hoppe, P.S., Schroeder, T., Vandenabeele, P., Bornkamm, G.W., Greten, F.R.   +9 more
openaire   +3 more sources

Selenoprotein gene nomenclature [PDF]

, 2016
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis.
Arn\ue9r, Elias S., Berry, Marla J., Bruford, Elspeth A., Burk, Raymond F., Carlson, Bradley A., Castellano, Sergi, Chavatte, Laurent, Conrad, Marcus, Copeland, Paul R., Diamond, Alan M., Driscoll, Donna M., Ferreiro, Ana, Floh\ue9, Leopold, Gladyshev, Vadim N, Green, Fiona R., Guig\uf3, Roderic, Handy, Diane E., Hatfield, Dolph L., Hesketh, John, Hoffmann, Peter R., Holmgren, Arne, Hondal, Robert J., Howard, Michael T., Huang, Kaixun, K\uf6hrle, Josef, Kim, Hwa Young, Kim, Ick Young, Krol, Alain, Kryukov, Gregory V., Lee, Byeong Jae, Lee, Byung Cheon, Lei, Xin Gen, Lescure, Alain, Liu, Qiong, Lobanov, Alexei V., Loscalzo, Joseph, Maiorino, Matilde, Mariotti, Marco, Prabhu, K. Sandeep, Rayman, Margaret P., Regina, Brigelius Floh\ue9, Rozovsky, Sharon, Salinas, Gustavo, Schmidt, Edward E., Schomburg, Lutz, Schweizer, Ulrich, Simonovi\u107, Miljan, Sunde, Roger A., Tsuji, Petra A., Tweedie, Susan, Ursini, Fulvio, Whanger, Philip D., Zhang, Yan   +52 more
core   +3 more sources