Clinical and Translational Medicine, 2021 Background Platinum‐based chemotherapy is effective in inducing shrinkage of primary lung cancer lesions; however, it shows finite therapeutic efficacy in patients suffering from brain metastasis (BM).
Wenwen Liu +12 more
doaj +1 more source
The effect of vitamin C on the erythrocyte antioxidant enzymes in intoxicated-lead rat offsprings [PDF]
, 2013 Objective: Lead exposure or lead poisoning is known to cause a large spectrum of physiological, biochemical, and behavioural disorders in animals.
Eshginia, S., Marjani, A.
core +1 more source
Long chain lipid hydroperoxides increase the glutathione redox potential through glutathione peroxidase 4 [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2019 Peroxidation of PUFAs by a variety of endogenous and xenobiotic electrophiles is a recognized pathophysiological process that can lead to adverse health effects. Although secondary products generated from peroxidized PUFAs have been relatively well studied, the role of primary lipid hydroperoxides in mediating early intracellular oxidative events is ...
Elizabeth M, Corteselli +5 more
openaire +2 more sources
Glutathione peroxidase 4: a new player in neurodegeneration? [PDF]
Molecular Psychiatry, 2016 Glutathione peroxidase 4 (GPx4) is an antioxidant enzyme reported as an inhibitor of ferroptosis, a recently discovered non-apoptotic form of cell death. This pathway was initially described in cancer cells and has since been identified in hippocampal and renal cells.
B R, Cardoso +3 more
openaire +2 more sources
Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility. [PDF]
, 2015 The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell ...
Aichler, M +12 more
core +1 more source
Anti-cancer effect of thiacremonone through down regulation of peroxiredoxin 6. [PDF]
PLoS ONE, 2014 Thiacremonone (2, 4-dihydroxy-2, 5-dimethyl-thiophene-3-one) is an antioxidant substance as a novel sulfur compound generated from High-Temperature-High-Pressure-treated garlic.
Miran Jo +15 more
doaj +1 more source
Induction mechanism of ferroptosis: A novel therapeutic target in lung disease
Frontiers in Pharmacology, 2022 Ferroptosis is a newly discovered form of non-apoptotic regulatory cell death driven by iron-dependent lipid peroxidation. Ferroptosis significantly differs from other forms of cell death in terms of biochemistry, genetics, and morphology.
Lingyu Pan +6 more
doaj +1 more source
Ferroptosis in the pathogenesis of brain tumors [PDF]
Клиническая практика, 2023 The field of research on ferroptosis has seen an explosive growth in the past few years since the term was coined in 2012. This review highlights the current state of knowledge on the developmental mechanism of this unique mode of cell death, induced by ...
Alexandr A. Nikolaev +1 more
doaj +1 more source
Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]
, 2015 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi +38 more
core +1 more source
Induction of Glutathione Peroxidase 4 Expression during Enterocytic Cell Differentiation [PDF]
Journal of Biological Chemistry, 2011 Glutathione peroxidase 4 (GPx4), an abundant selenoenzyme, is ubiquitously expressed in a tissue-, cell- and differentiation-dependent manner, and it is localized in cytoplasmic, mitochondrial, and nuclear cellular compartments. Here, we report cytoplasmic and nuclear localization of GPx4 in Caco-2 intestinal epithelial cells.
Bodo, Speckmann +5 more
openaire +2 more sources