Results 61 to 70 of about 240,067 (266)

Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis

Haematologica, 2020
Glutathione peroxidase 4 (GPX4) is unique as it is the only enzyme that can prevent detrimental lipid peroxidation in vivo by reducing lipid peroxides to the respective alcohols thereby stabilizing oxidation products of unsaturated fatty acids.
Sandro Altamura, Naidu M. Vegi, Philipp S. Hoppe, Timm Schroeder, Michaela Aichler, Axel Walch, Katarzyna Okreglicka, Lothar Hültner, Manuela Schneider, Camilla Ladinig, Cornelia Kuklik-Roos, Josef Mysliwietz, Dirk Janik, Frauke Neff, Birgit Rathkolb, Mar tin Hrabé de Angelis, Christian Buske, Ana Rita da Silva, Katja Muedder, Marcus Conrad, Tomas Ganz, Manfred Kopf, Martina U. Muckenthaler, Georg W. Bornkamm   +23 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Role of ferroptosis in effects of anesthetics on multiple organ diseases: A literature review

Heliyon, 2023
Anesthesiologists are often faced with patients combined with a series of organ injuries, such as acute lung injury, myocardial ischemia-reperfusion injury, and neurodegenerative diseases.
Gulibositan Abudurousuli, Siyang Xu, Jinxing Che, Xiahao Ding, Bo Gui, Linjia Zhu   +5 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Anti‐proliferative and metastasis‐inhibiting effect of carbon ions on non‐small cell lung adenocarcinoma A549 cells

Precision Radiation Oncology, 2022
Objective Carbon ions suppress the effect of glutathione peroxidase 4 (GPX4) on the proliferation and metastasis of lung adenocarcinoma A549 cells.
Zhen Yang, Hongtao Luo, Shuangwu Feng, Yichao Geng, Xueshan Zhao, Chengcheng Li, Ruifeng Liu, Qiuning Zhang, Xiaohu Wang   +8 more
doaj   +1 more source

Maresin1 Suppresses High-Glucose-Induced Ferroptosis in Osteoblasts via NRF2 Activation in Type 2 Diabetic Osteoporosis

Cells, 2022
Maresin1 (MaR1) is an endogenous pro-resolving lipid mediator produced from polyunsaturated fatty acids and is believed to have antioxidant and anti-inflammatory properties.
Zhanwei Zhang, Chonghao Ji, Ya-Nan Wang, Shiyue Liu, Maoshan Wang, Xin Xu, Dongjiao Zhang   +6 more
doaj   +1 more source

Enhancement Glutathione Peroxidase Activity and α2-Macroglobulin Gene Expression of Macrobrachium Rosenbergii Fed with Aqueous Morinda Citrifolia Leaves Extract-Supplemented Diet [PDF]

, 2018
Morinda citrifolia, known commercially as noni is often used for enhance immunity, these plant rich of phenolic compound with antioxidant properties. In the present study, Macrobrachium rosenbergii were fed with diets containing of aqueous M.
Chang, C. C. (Chin), Halim, A. M. (Atika), Prajitno, A. (Arief)   +2 more
core  

Influence of salicylic acid on phytochelatin synthesis in Zea mays during Cd stress [PDF]

, 2013
: Presoaking maize (Zea mays) seeds in salicylic acid (SA) reduces damage caused by cadmium. In the present work the possible role of phytochelatins (PCs) in SA-mediated protection against Cd toxicity was investigated. Seeds were presoaked in 0.5 mM SA,
Janda, Tibor, Krantev, A., Popova, L. P., Szalai, Gabriella, Yordanova, R.   +4 more
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

Nature Communications, 2021
The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth.
Zhennan Shi, Nathchar Naowarojna, Zijian Pan, Yilong Zou   +3 more
doaj   +1 more source