Results 11 to 20 of about 21,313 (286)

Neural Precursor Cell-Expressed Developmentally Downregulated Protein 4 (NEDD4)-Mediated Ubiquitination of Glutathione Peroxidase 4 (GPX4): A Key Pathway in High-Glucose-Induced Ferroptosis in Corpus Cavernosum Smooth Muscle Cells. [PDF]

Biomolecules
Pharmacological treatment of diabetes mellitus-induced erectile dysfunction (DMED) has become increasingly challenging due to the limited efficacy of phosphodiesterase type 5 inhibitors (PDE5i). As the global prevalence of DM continues, there is a critical need for novel therapeutic strategies to address DMED.
Xu W, Hu P, Wang J, Jiang H, Wang T, Liu J, Li H.   +6 more
europepmc   +4 more sources

Oxysophoridine promotes osteoarthritis repair via GSH system activation and ROS suppression [PDF]

Scientific Reports
Osteoarthritis (OA) is a prevalent joint degenerative disease involving inflammation and oxidative stress, with reactive oxygen species (ROS) driving progression. Restoring joint redox balance mitigates cartilage damage. Osilyhizidine (OSR), from Sophora
Jun Tu, Zhiwei Peng, Xiyang Sun, Haobo Liu, Jianqi Zhao, Bin Xu, Xu Zhu, Baofang Liu   +7 more
doaj   +2 more sources

The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities

Biomedicines, 2022
The selenoprotein glutathione peroxidase 4 (GPX4) is one of the main antioxidant mediators in the human body. Its central function involves the reduction of complex hydroperoxides into their respective alcohols often using reduced Glutathione (GSH) as a ...
Kamari Weaver, Rachid Skouta
doaj   +1 more source

Liproxstatin-1 is an effective inhibitor of oligodendrocyte ferroptosis induced by inhibition of glutathione peroxidase 4

Neural Regeneration Research, 2021
Our previous studies showed that ferroptosis plays an important role in the acute and subacute stages of spinal cord injury. High intracellular iron levels and low glutathione levels make oligodendrocytes vulnerable to cell death after central nervous ...
Bao-You Fan, Yi-Lin Pang, Wen-Xiang Li, Chen-Xi Zhao, Yan Zhang, Xu Wang, Guang-Zhi Ning, Xiao-Hong Kong, Chang Liu, Xue Yao, Shi-Qing Feng   +10 more
doaj   +1 more source

mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Nature Communications, 2021
Glutathione peroxidase 4 (GPX4) inhibits ferroptosis, but protein synthesis is inefficient and costly. Here, the authors reveal that cystine uptake promotes GPX4 synthesis by activating mTORC1 and show that cancer cells are sensitized to ferroptosis by ...
Yilei Zhang, Robert V. Swanda, Litong Nie, Xiaoguang Liu, Chao Wang, Hyemin Lee, Guang Lei, Chao Mao, Pranavi Koppula, Weijie Cheng, Jie Zhang, Zhenna Xiao, Li Zhuang, Bingliang Fang, Junjie Chen, Shu-Bing Qian, Boyi Gan   +16 more
doaj   +1 more source

Post-Translational Modification of GPX4 is a Promising Target for Treating Ferroptosis-Related Diseases

Frontiers in Molecular Biosciences, 2022
Glutathione peroxidase 4 (GPX4) is one of the most important antioxidant enzymes. As the key regulator of ferroptosis, GPX4 has attracted considerable attention in the fields of cancer, cardiovascular, and neuroscience research in the past 10 years.
Can Cui, Fei Yang, Fei Yang, Qian Li, Qian Li, Qian Li   +5 more
doaj   +1 more source

Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3/GPX4 signalling

Cell Death and Disease, 2022
Ferroptosis is a new form of regulated cell death that is mediated by intracellular iron and ester oxygenase, and glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into ...
Weifan Zhang, Mengyuan Gong, Wunai Zhang, Jiantao Mo, Simei Zhang, Zeen Zhu, Xueni Wang, Bo Zhang, Weikun Qian, Zheng Wu, Qingyong Ma, Zheng Wang   +11 more
doaj   +1 more source

Multifaceted mechanisms mediating cystine starvation-induced ferroptosis

Nature Communications, 2021
The cyst(e)ine/glutathione (GSH)/glutathione peroxidase 4 (GPX4) axis is the most frequently targeted pathway to trigger the ferroptosis cascade and suppress tumor growth.
Zhennan Shi, Nathchar Naowarojna, Zijian Pan, Yilong Zou   +3 more
doaj   +1 more source

System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

Frontiers in Pharmacology, 2022
The activation of ferroptosis is a new effective way to treat drug-resistant solid tumors. Ferroptosis is an iron-mediated form of cell death caused by the accumulation of lipid peroxides.
Feng-Jiao Li, Feng-Jiao Li, Hui-Zhi Long, Hui-Zhi Long, Zi-Wei Zhou, Zi-Wei Zhou, Hong-Yu Luo, Hong-Yu Luo, Shuo-Guo Xu, Shuo-Guo Xu, Li-Chen Gao, Li-Chen Gao   +11 more
doaj   +1 more source

Association between Polymorphisms in Glutathione Peroxidase and Selenoprotein P Genes, Glutathione Peroxidase Activity, HRT Use and Breast Cancer Risk. [PDF]

, 2013
Breast cancer (BC) is one of the most common cancers in women. Evidence suggests that genetic variation in antioxidant enzymes could influence BC risk, but to date the relationship between selenoproteins and BC risk remains unclear.
A Crawford, A Jemal, A Meindl, A Steinbrecher, A Tjonneland, Anne Tjønneland, C Meplan, C Meplan, C Meplan, C Meplan, Catherine Méplan, CB Ambrosone, CW Elston, D Ratnasinghe, D Roy, DF Easton, DG Cox, DG Cox, E Jablonska, EJ Ha, FP Bellinger, G Bermano, G Ravn-Haren, G Riscuta, Gitte Ravn-Haren, J Ahn, J Hesketh, J Hu, J Wang, JA Knight, JA Mobley, JB Lopez-Saez, JD Yager, John Hesketh, K Charalabopoulos, L Forsberg, L Serra-Majem, L Vera-Ramirez, Lars Ove Dragsted, M Udler, MB Terry, ML Cooper, MP Rayman, PM Campeau, R Brigelius-Flohe, RD Hansen, RF Burk, RK Petersen, S Benzon Larsen, S Loft, S Peng, S Villette, SA Miller, SM Tsai, U Vogel, U Vogel, Ulla Vogel, William B. Coleman, X Zhou, Y Hu, Y Saito, YJ Hu   +61 more
core   +17 more sources