Results 211 to 220 of about 21,313 (286)

Ferroptosis‐Driven Neuronal Damage Exacerbation in Diabetic Stroke: Implications of SLC7A11 Inhibition

CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.
The current study uncovered aggravated cerebral ischemic injury and neurological dysfunction following diabetic stroke, in which ferroptosis was involved. SLC7A11 expression was inhibited in the early stages of reperfusion during diabetic stroke, and both ferroptosis inhibitors and neuron‐specific enforced expression of SLC7A11 mitigated neuronal lipid
Siyuan Liu, Min Liu, Binbin Wang, Miao Sun, Huikai Yang, Mengyao Qu, Libin Ma, Likai Shi, Yuxiang Song, Peng Li, Lulu Zhou, Wugang Hou, Weidong Mi, Yulong Ma   +13 more
wiley   +1 more source

Proteomic profiling of arteriovenous fistula tissue identifies dysregulated oxidoreductase proteins in diabetic end-stage renal disease. [PDF]

Front Endocrinol (Lausanne)
Zhao B, Zhan S, Zhou X, Yu P, Wang Y.
europepmc   +1 more source

Multi‐omic profiling defines three distinct molecular subtypes of urothelial carcinoma with implications for precision therapy

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
We developed three UC clusters, applicable for MIBC and NMIBC, which were validated using transcriptomic- and proteomic datasets. Publically available UC cell lines were assigned to the clusters, to have in vitro models representing each cluster. The clusters differ in molecular and biological signatures, with distinct prognostic and therapeutic ...
Nils C. H. van Creij, Piotr Tymoszuk, Florian Handle, Andreas Seeber, Teresa Sellemond, Agnieszka Martowicz, Eva Comperat, Hamed Wafa, Steffen Ormanns, Michael Günther, Walther Parson, Maxim Noeparast, Frédéric R. Santer, José Daniel Subiela, Petros Grivas, Roger Li, Zoran Culig, Renate Pichler   +17 more
wiley   +1 more source

Targeting ferroptosis with culinary spices: a dietary strategy for neuroprotection via the Nrf2/GPX4 axis. [PDF]

Front Nutr
Hong W, Qing Y, Liu J.
europepmc   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

Targeting ferroptosis to overcome drug resistance in lung cancer. [PDF]

Transl Lung Cancer Res
Sheng P, Jin J, Liu H, Sun C, Chen Y, Chen X, Ma D, Shen J.   +7 more
europepmc   +1 more source

Phloretin Suppresses Preadipocyte Differentiation by Targeting PPARγ/Transferrin to Activate Ferroptosis Signaling Pathway

Food Frontiers, Volume 7, Issue 2, March 2026.
Phloretin alleviates HFD‐induced obesity and suppresses adipogenesis by activating the ferroptosis pathway, potentially via targeting PPARγ and transferrin. ABSTRACT Phloretin, a plant‐derived dihydrochalcone bioactive compound, potentially modulates preadipocyte differentiation, although this remains controversial and requires further clarification ...
Jie Li, Qihui Zhu, Yang Li, Haiyu Zhao, Yi Bi, Chuanying Pan, Min Wang, Lin Han, Xianyong Lan   +8 more
wiley   +1 more source

Bridging innate immunity and iron-dependent death: the interplay between cyclic GMP-AMP synthase-stimulator of interferon genes nexus and ferroptosis in cancer and inflammation. [PDF]

Front Cell Dev Biol
Chen XX, Hou YQ, Chen XX, Zhou Q, Wang X.   +4 more
europepmc   +1 more source

Alginate Oligosaccharides Attenuate Ochratoxin A‐Induced Liver Injury through Regulating the Interaction of Nrf2 and NF‐κB Signaling Pathways

Food Frontiers, Volume 7, Issue 2, March 2026.
A schematic illustration for the protective effects of AOS on OTA‐induced liver injury in mice. AOS, alginate oligosaccharides; CAT, catalase; GSTT1, glutathione S‐transferase theta 1; HO‐1, heme oxygenase 1; IκBα, inhibitor kappa B alpha; IL‐1β, interleukin‐1β; IL‐6, interleukin‐6; Keap1, kelch‐like ech‐associated protein 1; NF‐κB, nuclear factor ...
Yue Zhao, Xueqing Ye, Yan Guo, Zhongxiang Zhao, Qinghua Yao, Yaoyao Wang, Huimei Liu, Ziwei Lin, Wenchao Liu   +8 more
wiley   +1 more source

Ferroptosis inhibition and mitochondrial rescue: a novel mechanism of emodin in rheumatoid arthritis. [PDF]

Redox Rep
Zhou L, Liu J, Ren J, Du D, Rong X.
europepmc   +1 more source