Results 31 to 40 of about 21,313 (286)

Effect of plant-based feed ingredients on osmoregulation in the Atlantic salmon lens [PDF]

, 2010
Lenses of adult Atlantic salmon fed with a plant oil and plant protein-based diet (plant diet) were compared to lenses of fish fed a diet based on traditional marine ingredients (marine diet) with respect to biochemical composition and functionality ex ...
Baslow, Bell, Bell, Bell, Bjerkås, Bjerkås, Bjerkås, Bjerkås, Breck, Breck, Breck, Breck, Brodtkorb, Chan, Christiane Tröβe, Delamere, Duston, Hargis, Hawse, Iwata, Jeremy D. Rhodes, Jobling, Jordal, Julie Sanderson, Kantorow, Lu, Menzies, Mizuno, Ng, Nilsen, Olav Breck, Rune Waagbø, Sneddon, Sutherland, Tacon, Toivonen, Torstensen, Torstensen, Torstensen, Tröβe, Tröβe, Turchini, Untergasser, Ursini, Vandesompele, Vemuri, Virtanen, Waagbø, Waagbø, Waagbø, Wall, Yeagle, Zhang   +52 more
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Rat liver antioxidant response to iron and copper overloads [PDF]

, 2014
The rat liver antioxidant response to Fe and Cu overloads (0–60 mg/kg) was studied. Dose- and time-responses were determined and summarized by t1/2 and C50, the time and the liver metal content for half maximal oxidative responses.
Boveris, Alberto Antonio, Castro-Parodi, Mauricio Omar, Damiano, Alicia Ermelinda, Ferrarotti, Nidia Fatima, Musacco Sebio, Rosario Natalia, Repetto, Marisa Gabriela, Saporito Magriñá, Christian Martín, Semprine, Jimena Vanina, Torti, Horacio Emilio   +8 more
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Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

Redox Biology, 2016
The selenoenzyme glutathione peroxidase 4 (Gpx4) is an essential mammalian glutathione peroxidase, which protects cells against detrimental lipid peroxidation and governs a novel form of regulated necrotic cell death, called ferroptosis.
Bradley A. Carlson, Ryuta Tobe, Elena Yefremova, Petra A. Tsuji, Victoria J. Hoffmann, Ulrich Schweizer, Vadim N. Gladyshev, Dolph L. Hatfield, Marcus Conrad   +8 more
doaj   +1 more source

Deubiquitinase OTUD5 as a Novel Protector against 4‐HNE‐Triggered Ferroptosis in Myocardial Ischemia/Reperfusion Injury

Advanced Science, 2023
Despite the development of advanced technologies for interventional coronary reperfusion after myocardial infarction, a substantial number of patients experience high mortality due to myocardial ischemia‐reperfusion (MI/R) injury.
Lulu Liu, Jiaojiao Pang, Dandan Qin, Ruochuan Li, Dan Zou, Kai Chi, Wenxiao Wu, Haiying Rui, Huaxiang Yu, Wenyong Zhu, Kai Liu, Xuting Wu, Jinxin Wang, Ping Xu, Xiaoshuai Song, Yihai Cao, Jiali Wang, Feng Xu, Li Xue, Yuguo Chen   +19 more
doaj   +1 more source

Selenoprotein gene nomenclature [PDF]

, 2016
The human genome contains 25 genes coding for selenocysteine-containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis.
Arn\ue9r, Elias S., Berry, Marla J., Bruford, Elspeth A., Burk, Raymond F., Carlson, Bradley A., Castellano, Sergi, Chavatte, Laurent, Conrad, Marcus, Copeland, Paul R., Diamond, Alan M., Driscoll, Donna M., Ferreiro, Ana, Floh\ue9, Leopold, Gladyshev, Vadim N, Green, Fiona R., Guig\uf3, Roderic, Handy, Diane E., Hatfield, Dolph L., Hesketh, John, Hoffmann, Peter R., Holmgren, Arne, Hondal, Robert J., Howard, Michael T., Huang, Kaixun, K\uf6hrle, Josef, Kim, Hwa Young, Kim, Ick Young, Krol, Alain, Kryukov, Gregory V., Lee, Byeong Jae, Lee, Byung Cheon, Lei, Xin Gen, Lescure, Alain, Liu, Qiong, Lobanov, Alexei V., Loscalzo, Joseph, Maiorino, Matilde, Mariotti, Marco, Prabhu, K. Sandeep, Rayman, Margaret P., Regina, Brigelius Floh\ue9, Rozovsky, Sharon, Salinas, Gustavo, Schmidt, Edward E., Schomburg, Lutz, Schweizer, Ulrich, Simonovi\u107, Miljan, Sunde, Roger A., Tsuji, Petra A., Tweedie, Susan, Ursini, Fulvio, Whanger, Philip D., Zhang, Yan   +52 more
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Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury

Nature Communications, 2023
Ferroptosis is an iron-dependent programmed cell death associated with severe kidney diseases, linked to decreased glutathione peroxidase 4 (GPX4). However, the spatial distribution of renal GPX4-mediated ferroptosis and the molecular events causing GPX4
Li-Kai Chu, Xu Cao, Lin Wan, Qiang Diao, Yu Zhu, Yu Kan, Li-Li Ye, Yi-Ming Mao, Xing-Qiang Dong, Qian-Wei Xiong, Ming-Cui Fu, Ting Zhang, Hui-Ting Zhou, Shi-Zhong Cai, Zhou-Rui Ma, Ssu-Wei Hsu, Reen Wu, Ching-Hsien Chen, Xiang-Ming Yan, Jun Liu   +19 more
doaj   +1 more source

A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis

Molecular & Cellular Oncology, 2021
Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
doaj   +1 more source

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition. [PDF]

, 2017
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells.
Berens, Michael E, Bole, Dhruv, Dhruv, Harshil D, Eaton, John K, Galeas, Jacqueline, Hangauer, Matthew J, Matov, Alexandre, McCormick, Frank, McManus, Michael T, Ryan, Matthew J, Schreiber, Stuart L, Viswanathan, Vasanthi S   +11 more
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Obesity in a model of haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy [PDF]

, 2015
Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a selenoenzyme that selectively neutralizes lipid
Aldini, Aldini, Anderson, Anderson, Anderson, Anderson, Anderson, Anderson, Baseler, Behring, Berndt, Bhatt, Biernacka, Blair, Borisov, Brigelius-Flohe, Brigelius-Flohe, Burgmaier, Catala, Chavez, Chicco, Cole-Ezea, Conrad, Crosley, Curtis, Dabkowski, Danaei, Dobaczewski, Du, Esterbauer, Fisher-Wellman, Frangogiannis, Frezza, Fritz, Frohnert, Frustaci, Fry, Ghosh, Gostimskaya, Guichardant, Guichardant, Hill, Hill, Hoffmann, Houstis, Imai, Imai, Januszewski, Kang, Kass, Kendig, Khan, Kiencke, Lashin, Li, Li, Liang, Liang, Little, LoPachin, LoPachin, Loscalzo, Maier, Maiorino, Maiorino, Menini, Meplan, Merry, Minko, Morgan, Nair, Nakamura, Ng, Okada, Opie, Paradies, Polonikov, Porcar-Almela, Qin, Ran, Ran, Refsgaard, Rindler, Ruperez, Scimeca, Selvin, Sharma, Shimozu, Siems, Sneddon, Stanley, Stanley, Sverdlov, Thorpe, Tsujita, Uchida, Uchida, Villette, West, Wilson, Xie, Yant   +101 more
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Evidences for a role of glutathione peroxidase 4 (GPx4) in methylmercury induced neurotoxicity in vivo

Toxicology, 2012
We evaluated the activity and expression of antioxidant enzymes in the cerebellum and cortex of Swiss adult male mice exposed to methylmercury (MeHg) in drinking water (40mg/L) during 21 days. The activity of glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), catalase (CAT), superoxide dismutase (SOD) and ...
Zemolin, A.P.P., Meinerz, D.F., de Paula, M.T., Mariano, D.O.C., Rocha, J.B.T., Pereira, A.B., Posser, T., Franco, J.L.   +7 more
openaire   +2 more sources