Scientific Reports, 2022 Papillary thyroid carcinoma (PTC) demonstrates significantly reduced patient survival with metastatic progression. Tumor progression can be influenced by metabolism, including antioxidant glutathione (GSH).
Konjeti R. Sekhar +7 more
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Concentration of glutathione and expression of glutathione peroxidases 1 and 4 in fresh sperm provide a forecast of the outcome of cryopreservation of human spermatozoa [PDF]
, 2004 Oxidative stress imbalance potentially leads to damage of the structure of the cell and macromolecules such as plasma membrane components, proteins, and DNA.
Garrido, N. +4 more
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Involvement of sperm acetylated histones and the nuclear isoform of Glutathione peroxidase 4 in fertilization [PDF]
, 2017 We previously demonstrated that the nuclear form of Glutathione peroxidase 4 (nGPx4) has a peculiar distribution in sperm head, being localized to nuclear matrix and acrosome and that sperm lacking nGPx4 are more prone to decondensation in vitro. In this
Boitani, Carla +8 more
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Mitochondrial glutathione: Features, regulation and role in disease [PDF]
, 2012 El pdf del artículo es la versión post-print.[Background]: Mitochondria are the powerhouse of mammalian cells and the main source of reactive oxygen species (ROS) associated with oxygen consumption.
Marí, Montserrat +5 more
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Ferroptosis: An emerging therapeutic opportunity for cancer
Genes and Diseases, 2022 Ferroptosis, a new form of non-apoptotic, regulated cell death characterized by iron dependency and lipid peroxidation, is involved in many pathological conditions such as neurodegenerative diseases, heart ischemia/reperfusion injury, acute renal failure,
Liyuan Wang +2 more
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Gene expression profile of oxidative stress in the lung of inbred mice after intestinal ischemia/reperfusion injury [PDF]
, 2014 PURPOSE:To determine the gene expression profile associated with oxidative stress and antioxidant defense in the lung tissue of mice subjected to intestinal ischemia and reperfusion.METHODS:Twelve male, inbred mice (C57BL/6) were randomly assigned to one
Bertoletto, Eduardo Rodrigues +7 more
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Regulation of Redox Signaling by Selenoproteins [PDF]
, 2010 The unique chemistry of oxygen has been both a resource and threat for life on Earth for at least the last 2.4 billion years. Reduction of oxygen to water allows extraction of more metabolic energy from organic fuels than is possible through anaerobic ...
Wayne Chris Hawkes, Zeynep Alkan
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Frontiers in Physiology, 2021 Pyruvate kinase deficiency (PKD) is a rare congenital hemolytic anemia caused by mutations in the PKLR gene. Here, we review pathophysiological aspects of PKD, focusing on the interplay between pyruvate kinase (PK)-activity and reticulocyte maturation in
Annelies Johanna van Vuren +2 more
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The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. [PDF]
, 2019 Ferroptosis is a form of regulated cell death that is caused by the iron-dependent peroxidation of lipids1,2. The glutathione-dependent lipid hydroperoxidase glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid hydroperoxides into non-
A Arroyo +43 more
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Sub-toxic Ethanol Exposure Modulates Gene Expression and Enzyme Activity of Antioxidant Systems to Provide Neuroprotection in Hippocampal HT22 Cells [PDF]
, 2016 Ethanol is known to cause severe systemic damage often explained as secondary to oxidative stress. Brain is particularly vulnerable to ethanol-induced reactive oxygen species (ROS) because the high amounts of lipids, and because nerve cell membranes ...
Casañas-Sánchez, Verónica +3 more
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