Results 81 to 90 of about 21,313 (286)

Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle [PDF]

, 2013
Increased fatty acid availability and oxidative stress are physiological consequences of exercise (Ex) and a high-fat, high-sugar (HFHS) diet. Despite these similarities, the global effects of Ex are beneficial, whereas HFHS diets are largely deleterious
Adimora, Alt, Anderson, Anderson, Anderson, Anderson, Anderson, Anderson, Aon, Ascensão, Baynes, Befroy, Cao, Carlberg, Christopher J. Wingard, Conrad, Conrad, Esterbauer, Ethan J. Anderson, Fisher-Wellman, Frasier, Go, Haram, Hoehn, Horstkotte, Houstis, Humphries, Iacobini, Jones, Justin D. La Favor, Kathleen Thayne, Kelsey H. Fisher-Wellman, Kemp, Khanna, La Favor, Lalage A. Katunga, McLain, Morino, P. Darrell Neufer, Perry, Petersen, Powers, Powers, Rindler, Robert C. Hickner, Saks, Schafer, Shanmugam, Sibbing, Skovbro, Stanley, Tamion, Taylor A. Mattox, Tietze, Toyokuni, Tsien, Wisløff, Yeh, Yonehara   +58 more
core   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source

MMP9 drives ferroptosis by regulating GPX4 and iron signaling

iScience
Summary: Ferroptosis, defined by the suppression of glutathione peroxidase-4 (GPX4) and iron overload, is a distinctive form of regulated cell death.
Flobater I. Gawargi, Paras K. Mishra
doaj   +1 more source

Activation of Glutathione Peroxidase 4 as a Novel Anti-inflammatory Strategy

Frontiers in Pharmacology, 2018
The anti-oxidative enzyme, glutathione peroxidase 4 (GPX4), helps to promote inflammation resolution by eliminating oxidative species produced by the arachidonic acid (AA) metabolic network.
Cong Li, Xiaobing Deng, Xiaowen Xie, Ying Liu, Ying Liu, José Pedro Friedmann Angeli, Luhua Lai, Luhua Lai, Luhua Lai   +8 more
doaj   +1 more source

A systems biology approach to deciphering the etiology of steatosis employing patient-derived dermal fibroblasts and iPS cells. [PDF]

, 2012
Nonalcoholic fatty liver disease (NAFLD) comprises a broad spectrum of disease states ranging from simple steatosis to nonalcoholic steatohepatitis (NASH).
Andriani eDaskalaki, Christian eRegenbrecht, Christoph eWierling, Frauke eHenjes, Hans eLehrach, Hans eLehrach, Hans eWesterhoff, Hans eWesterhoff, Hans eWesterhoff, Hans eWesterhoff, Ivano eBertini, James eAdjaye, James eAdjaye, Justyna eJozefczuk, Karl eKashofer, Kurt eZatloukal, Paola eTurano, Ramesh eUmmanni, Ramesh eUmmanni, Samrina eRehman, Suzanne eGeenen, Ulrike eKorf, Wasco eWruck   +22 more
core   +5 more sources

Palmitoylation‐Mediated Ubiquitination of SRPK1 Regulates Ferroptosis in High‐Fat‐Induced Erectile Dysfunction

Advanced Science, EarlyView.
Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan, Ke‐Fan Li, Yi‐Ming Yuan, Man‐Cheng Xia, Fang‐Zhou Zhao, Hong‐Gang Ying, Zhuo Zhou, Peng‐Chao Gao, Guo‐Qing Xie, Xue‐Song Li, Hui Jiang, Rui‐Li Guan   +11 more
wiley   +1 more source

Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents [PDF]

, 2011
Background Protein and mRNA levels for several selenoproteins, such as glutathione peroxidase-1 (Gpx1), are down-regulated dramatically by selenium (Se) deficiency.
Anna M Raines, Roger A Sunde
core   +1 more source

NIR‐Activatable Domino Cascade Catalysis Nanozyme Reactor for Multi‐Mechanism Synergistic Immunotherapy in Bladder Cancer

Advanced Science, EarlyView.
This study presents an intravesical delivery strategy of ferroptosis‐ and immunity‐inducing nanozyme‐loaded thermoresponsive hydrogels (FMCC@PNH) for enhanced bladder cancer therapy. Abstract Current intravesical therapies for bladder cancer after resection are limited by poor tissue penetration, off‐target effects, and insufficient efficacy.
Yongnan Jiang, Qingling Zhang, Yuhan Zhang, Xinlu Yu, Bo Jia, Yulong Dong, Yalong Wu, Kelong Fan, Xinquan Gu, Lei Ji, Wei Jiang, Bin Liu   +11 more
wiley   +1 more source

Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation

Pain and Therapy
Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes a significant global public health issue. Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized
Shiwen Fan, Kaixin Wang, Tianhao Zhang, Daling Deng, Jiwei Shen, Bowen Zhao, Daan Fu, Xiangdong Chen   +7 more
doaj   +1 more source

Biomarkers of selenium status in dogs [PDF]

, 2016
Background: Inadequate dietary selenium (Se) intake in humans and animals can lead to long term health problems, such as cancer. In view of the owner's desire for healthy longevity of companion animals, the impact of dietary Se provision on long term ...
Du Laing, Gijs, Gray, Kerry, Hesta, Myriam, Janssens, Geert, Staunton, Ruth, Van Zelst, Marielle   +5 more
core   +2 more sources