The effect of vitamin C on the erythrocyte antioxidant enzymes in intoxicated-lead rat offsprings [PDF]
, 2013 Objective: Lead exposure or lead poisoning is known to cause a large spectrum of physiological, biochemical, and behavioural disorders in animals.
Eshginia, S., Marjani, A.
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Fragment-based discovery of a regulatory site in thioredoxin glutathione reductase acting as "doorstop" for NADPH entry [PDF]
, 2018 Members of the FAD/NAD-linked reductase family are recognized as crucial targets in drug development for cancers, inflammatory disorders, and infectious diseases.
Angelucci, Francesco +16 more
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Mitochondrial thiol-disulfide system under acute hypoxia and hypoxic-hyperoxic adaptation [PDF]
The Ukrainian Biochemical Journal, 2014 The authors investigated the state of mitochondrial glutathione pool (reduced and oxidized glutathione, protein-GSH mixed disulfides), content of carbonyl groups and free sulfhydryl groups of proteins, protein expression of key mitochondrial antioxidant ...
O. A. Gonchar, I. N. Mankovska
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Cytosolic redox components regulate protein homeostasis via additional localisation in the mitochondrial intermembrane space [PDF]
, 2017 Oxidative protein folding is confined to the bacterial periplasm, endoplasmic reticulum and the mitochondrial intermembrane space. Maintaining a redox balance requires the presence of reductive pathways.
Cardenas-Rodriguez, Mauricio +1 more
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Understanding cisplatin resistance using cellular models [PDF]
, 2007 Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, Mary W., Stordal, Britta
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Regulatory Mechanisms in Biosystems, 2019 The activity of antioxidant protection enzymes in the blood serum and colon mucosa in rats was studied under the conditions of 28-days administration of omeprazole on its own and omeprazole together with multiprobiotics "Symbiter" and "Apibact ...
S. V. Pylypenko, A. A. Koval
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Paradoxical roles of antioxidant enzymes:Basic mechanisms and health implications [PDF]
, 2015 Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are generated from aerobic metabolism, as a result of accidental electron leakage as well as regulated enzymatic processes.
Amit R. Reddi +38 more
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Медицинский вестник Юга России, 2015 Purpose: to research the glutathione system state in rat tissues after trauma of the musculoskeletal system in a methionineinduced hyperhomocysteinemia.Materials and methods: the level of homocysteine in the plasma of animals, as well as the amount of ...
I. A. Alliluev +6 more
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Adaptive response to oxidative stress in the filamentous fungus Aspergillus niger B1-D [PDF]
, 2008 In the present study, we used a recombinant filamentous fungus strain, Aspergillus niger B1-D, as a model system, and investigated the antioxidant defences in this organism.
Harvey, L.M., Li, Qiang, Mcneil, Brian
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Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]
, 2011 <p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I. +7 more
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