Results 51 to 60 of about 311,263 (293)

Intracellular glutathione pools are heterogeneously concentrated [PDF]

, 2013
Glutathione is present in millimolar concentrations in the cell, but its relative distribution among cellular compartments remains elusive. We have chosen the endoplasmic reticulum (ER) as an example organelle to study compartment-specific glutathione ...
Christine Tachibana, Jakob Rahr Winther, Rahr Winther, Jakob, Winther, Jakob R., Appenzeller-Herzog, Christian, Davide Montero, Tachibana, Christine, Christian Appenzeller-Herzog, Montero, Davide   +8 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Bioaccumulation and biochemical responses in mussels exposed to the water-accommodated fraction of the Prestige fuel oil

Scientia Marina, 2007
The activity of the antioxidant defences catalase (CAT, EC 1.11.1.6), glutathione peroxidase (t-GPX, EC 1.11.1.9), glutathione reductase (GR, EC 1.6.4.2), phase II glutathione S-transferase (GST, EC 2.5.1.18) along with the NADPH-dependent cytochrome c ...
Montserrat Solé, Astrid Buet, Laura Ortiz, Francesc Maynou, Josep Maria Bayona, Joan Albaigés   +5 more
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

Glutathione cycle in diquat neurotoxicity: Assessed by intrastriatal pre-treatment with glutathione reductase [PDF]

Acta Veterinaria, 2013
Diquat (DQ) neurotoxicity mechanisms are unknown, although, it's systemic toxicity is mediated by free radical reactions. The role of glutathione cycle was assessed by glutathione reductase (GR) applied in the pre-treatment of DQ poisoning.
Đurđević Dragan, Đukić Mirjana, Ninković Milica, Stevanović Ivana, Jovanović Marina, Vasić Una   +5 more
doaj   +1 more source

CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress [PDF]

, 2016
The glutathione/cysteine exporter CydDC maintains redox balance in Escherichia coli. A cydD mutant strain was used to probe the influence of CydDC upon reduced thiol export, gene expression, metabolic perturbations, intracellular pH homeostasis, and ...
Sanguinetti, Guido, Holyoake, L.V., Rowe, Michelle L, Holyoake, Louise V, Howard, Mark J., Sanguinetti, G., Howard, Mark J, Rowe, M.L., Poole, Robert K, Poole, R.K., Hunt, Stuart, Cook, Gregory M, Hunt, S., Shepherd, M., Rowe, Michelle L., Shepherd, Mark, Howard, M.J., Cook, G.M.   +17 more
core   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

Protective Effect of Wild Ginseng Extract against y-BHP-induced Oxidative Damage in HepG2 Cells Using DNA Chip

Journal of Pharmacopuncture, 2007
Objectives : This study was carried out to examine protective effect of wild ginseng extract on HepG2 human hepatoma cell line against tert-Butyl hydroperoxide (t-BHP)-induced oxidative damage.
Hyung-Seok Kim, Hee-Soo Park, Ki-Rok Kwon   +2 more
doaj   +1 more source

Effects of lanthanum on the antioxidant capacity of chloroplasts and chlorophyll fluorescence parameters of maize seedlings under chromium stress

Photosynthetica, 2019
Effects of lanthanum chloride (LaCl3) on chromium tolerance of maize were investigated at chloroplast level. The results showed that Cr stress significantly increased activities of ascorbate peroxidase, glutathione reductase, monodehydro-ascorbate ...
H. DAI, C. SHAN
doaj   +1 more source

Glutathione reductase activity with an oxidized methylated glutathione analog

Journal of Enzyme Inhibition and Medicinal Chemistry, 2013
The activity of glutathione reductase with an unnatural analog of oxidized glutathione was explored. The analog, L-γ-glutamyl-2-methyl-L-cysteinyl-glycine disulfide, places an additional methyl group on the alpha position of each of the central cysteine residues, which significantly increases steric bulk near the disulfide bond.
Kedrowski, Brant L., Gutow, Jonathan H., Stock, Gorman, Smith, Maureen, Jordan, Chondrea, Masterson, Douglas S.   +5 more
openaire   +2 more sources