Results 11 to 20 of about 148,506 (307)

Versatility of Glutathione Transferase Proteins [PDF]

Biomolecules, 2023
For more than 60 years, glutathione transferases (GSTs) have attracted attention, but the research field of the GSTome [...]
Bengt Mannervik
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Polymorphisms in Genes Encoding Glutathione Transferase Pi and Glutathione Transferase Omega Influence Prostate Cancer Risk and Prognosis [PDF]

Frontiers in Molecular Biosciences, 2021
Considering the pleiotropic roles of glutathione transferase (GST) omega class members in redox homeostasis, we hypothesized that polymorphisms in GSTO1 and GSTO2 might contribute to prostate cancer (PC) development and progression.
Veljko Santric, Veljko Santric, Dejan Dragicevic, Dejan Dragicevic, Marija Matic, Marija Matic, Milica Djokic, Marija Pljesa-Ercegovac, Marija Pljesa-Ercegovac, Tanja Radic, Sonja Suvakov, Sonja Suvakov, Marina Nikitovic, Marina Nikitovic, Vesna Stankovic, Vesna Stankovic, Bogomir Milojevic, Bogomir Milojevic, Milan Radovanovic, Milan Radovanovic, Zoran Dzamic, Zoran Dzamic, Tatjana Simic, Tatjana Simic, Tatjana Simic, Ana Savic-Radojevic, Ana Savic-Radojevic   +26 more
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Glutathione transferase P1 is modified by palmitate. [PDF]

PLoS ONE
Glutathione transferase P1 (GSTP1) is a multi-functional protein that protects cells from electrophiles by catalyzing their conjugation with glutathione, and contributes to the regulation of cell proliferation, apoptosis, and signalling.
Vanessa Marensi, Megan C Yap, Yuhuan Ji, Cheng Lin, Luc G Berthiaume, Elaine M Leslie   +5 more
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Novel coumarin-6-sulfonamide-chalcone hybrids as glutathione transferase P1-1 inhibitors. [PDF]

PLoS ONE
Multidrug resistance (MDR) mechanisms in cancer cells are greatly influenced by glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as hGSTP1-1 inhibitors is considered an effective approach to overcome MDR.
Ahmed Sabt, Stefanos Kitsos, Manal S Ebaid, Veronika Furlan, Panagiota D Pantiora, Magdalini Tsolka, Eslam B Elkaeed, Mohamed Farouk Hamissa, Nikolaos Angelis, Ourania E Tsitsilonis, Anastassios C Papageorgiou, Urban Bren, Nikolaos E Labrou   +12 more
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Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase [PDF]

Antioxidants, 2022
Glutathione is an important antioxidant that plays a crucial role in the cellular protection against oxidative stress and detoxification of electrophilic mutagens, and carcinogens.
Juan Segura-Aguilar, Patricia Muñoz, Jose Inzunza, Mukesh Varshney, Ivan Nalvarte, Bengt Mannervik   +5 more
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Glutathione Transferase P1: Potential Therapeutic Target in Ovarian Cancer [PDF]

Medicina, 2022
Chemotherapy resistance of ovarian cancer, regarded as the most lethal malignant gynecological disease, can be explained by several mechanisms, including increased activity of efflux transporters leading to decreased intracellular drug accumulation ...
Petar Simic, Igor Pljesa, Lazar Nejkovic, Djurdja Jerotic, Vesna Coric, Jelena Stulic, Nenad Kokosar, Dunja Popov, Ana Savic-Radojevic, Vladimir Pazin, Marija Pljesa-Ercegovac   +10 more
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Glutathione Transferase (GST)-Activated Prodrugs

Pharmaceutics, 2013
Glutathione transferase (formerly GST) catalyzes the inactivation of various electrophile-producing anticancer agents via conjugation to the tripeptide glutathione.
Andrea Calderan, Paolo Ruzza
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Glutathione Transferases [PDF]

The Arabidopsis Book, 2010
The 55 Arabidopsis glutathione transferases (GSTs) are, with one microsomal exception, a monophyletic group of soluble enzymes that can be divided into phi, tau, theta, zeta, lambda, dehydroascorbate reductase (DHAR) and TCHQD classes. The populous phi and tau classes are often highly stress inducible and regularly crop up in proteomic and ...
David P, Dixon, Robert, Edwards
openaire   +3 more sources

Glutathione transferases in bacteria [PDF]

The FEBS Journal, 2008
Bacterial glutathione transferases (GSTs) are part of a superfamily of enzymes that play a key role in cellular detoxification. GSTs are widely distributed in prokaryotes and are grouped into several classes. Bacterial GSTs are implicated in a variety of distinct processes such as the biodegradation of xenobiotics, protection against chemical and ...
ALLOCATI, Nerino, FEDERICI, Luca, MASULLI, Michele, DI ILIO, Carmine   +3 more
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Glutathione-binding site of a bombyx mori theta-class glutathione transferase. [PDF]

PLoS ONE, 2014
The glutathione transferase (GST) superfamily plays key roles in the detoxification of various xenobiotics. Here, we report the isolation and characterization of a silkworm protein belonging to a previously reported theta-class GST family.
M D Tofazzal Hossain, Naotaka Yamada, Kohji Yamamoto   +2 more
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