Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase [PDF]
Antioxidants, 2022 Glutathione is an important antioxidant that plays a crucial role in the cellular protection against oxidative stress and detoxification of electrophilic mutagens, and carcinogens.
Patricia Munoz +2 more
exaly +4 more sources
Versatility of Glutathione Transferase Proteins [PDF]
Biomolecules, 2023 For more than 60 years, glutathione transferases (GSTs) have attracted attention, but the research field of the GSTome [...]
Bengt Mannervik
doaj +2 more sources
Polymorphisms in Genes Encoding Glutathione Transferase Pi and Glutathione Transferase Omega Influence Prostate Cancer Risk and Prognosis [PDF]
Frontiers in Molecular Biosciences, 2021 Considering the pleiotropic roles of glutathione transferase (GST) omega class members in redox homeostasis, we hypothesized that polymorphisms in GSTO1 and GSTO2 might contribute to prostate cancer (PC) development and progression.
Veljko Santric +26 more
doaj +2 more sources
Glutathione transferase P1 is modified by palmitate. [PDF]
PLoS ONEGlutathione transferase P1 (GSTP1) is a multi-functional protein that protects cells from electrophiles by catalyzing their conjugation with glutathione, and contributes to the regulation of cell proliferation, apoptosis, and signalling.
Vanessa Marensi +5 more
doaj +2 more sources
Glutathione Transferase (GST)-Activated Prodrugs
Pharmaceutics, 2013 Glutathione transferase (formerly GST) catalyzes the inactivation of various electrophile-producing anticancer agents via conjugation to the tripeptide glutathione.
Paolo Ruzza, Andrea Calderan
exaly +3 more sources
Novel coumarin-6-sulfonamide-chalcone hybrids as glutathione transferase P1-1 inhibitors. [PDF]
PLoS ONEMultidrug resistance (MDR) mechanisms in cancer cells are greatly influenced by glutathione transferase P1-1 (hGSTP1-1). The use of synthetic or natural compounds as hGSTP1-1 inhibitors is considered an effective approach to overcome MDR.
Ahmed Sabt +12 more
doaj +2 more sources
Glutathione Transferase P1: Potential Therapeutic Target in Ovarian Cancer [PDF]
Medicina, 2022 Chemotherapy resistance of ovarian cancer, regarded as the most lethal malignant gynecological disease, can be explained by several mechanisms, including increased activity of efflux transporters leading to decreased intracellular drug accumulation ...
Petar Simic +10 more
doaj +2 more sources
Toxicity induced by Solanapyrone A in Chickpea shoots and its metabolism through Glutathione/Glutathione-S-Transferase system [PDF]
, 2013 Solanapyrone A and C were isolated from a Pakistani isolate of Ascochyta rabiei, Pk-1. Two experiments were conducted to investigate the phytotoxic effects of the most potent toxin, solanapyrone A on chickpea cultivars and its subsequent detoxification ...
Riaz, A. +5 more
core +7 more sources
Glutathione Transferases [PDF]
The Arabidopsis Book, 2010 The 55 Arabidopsis glutathione transferases (GSTs) are, with one microsomal exception, a monophyletic group of soluble enzymes that can be divided into phi, tau, theta, zeta, lambda, dehydroascorbate reductase (DHAR) and TCHQD classes. The populous phi and tau classes are often highly stress inducible and regularly crop up in proteomic and ...
David P, Dixon, Robert, Edwards
openaire +3 more sources
The role of glutathione transferases in TNT detoxification [PDF]
, 2012 Glutathione transferases (GSTs) are multi-functional enzymes with an important role in plant biochemical mechanisms of xenobiotic detoxification. The GSTs have been extensively studied due to their ability to detoxify herbicides; recently they have been ...
Gunning, Vanda
core +6 more sources