Results 81 to 90 of about 202,820 (240)

Recombinant human preproinsulin expression, purification and reaction with insulin autoantibodies in sera from patients with insulin-dependent diabetes mellitus [PDF]

, 1993
A novel prokaryotic expression vector pGEX-6T was designed for high-level expression of recombinant fusion protein with a histidine-hexapeptide and glutathione-S-transferase at its N-terminus and the recombinant human preproinsulin at its C-terminus ...
Amman, Atkinson, Baekkeskov, Baekkeskov, Berthold, Boitard, Bottazzo, Castano, Dean, Frorath, Goedel, Greenbaum, Harrison, Heike Berg, Hopp, Jochen Seissler, Karjalainen, Kaufman, Kuglin, Kuglin, Ludwig Mauch, Michael Walter, Palmer, Patrick, Seissler, Smith, Smith, Snyder, Su, Wolfgang Northemann   +29 more
core   +1 more source

Cryo‐Inactivated Cancer Cells Derived Magnetic Micromotors for Tumor Immunotherapy

Advanced Science, EarlyView.
Cryo‐inactivated cancer cell‐based magnetic micromotors are developed for synergistic tumor immunotherapy via magnetic targeting. These micromotors can induce ferroptosis and immunogenic cell death, deliver tumor antigens, and activate the Mn2+‐dependent cGAS‐STING pathway. The system effectively suppresses tumor progression, recurrence, and metastasis,
Qingfei Zhang, Gaizhen Kuang, Wenzhao Li, Yuanjin Zhao   +3 more
wiley   +1 more source

A Needle‐Like H2S‐Releasing and H2O2 Self‐Replenishing Nanoplatform for Enhanced Chemodynamic Tumor Immunotherapy

Advanced Science, EarlyView.
The PTA‐SnS2@GOx cascade nanosystem presents a smart paradigm for cancer theranostics, integrating self‐supplied H2S/H2O2‐augmented chemodynamic therapy (CDT) with sensitized immunotherapy. Its needle‐like SnS2 shell enhances tumor‐specific uptake, ensuring biosafety.
Xiaoxiao Sun, Xia Zhang, Haiyan Qin, Lingling Li   +3 more
wiley   +1 more source

Metabolic syndrome influences cardiac gene expression pattern at the transcript level in male ZDF rats [PDF]

, 2013
Background: Metabolic syndrome (coexisting visceral obesity, dyslipidemia, hyperglycemia, and hypertension) is a prominent risk factor for cardiovascular morbidity and mortality, however, its effect on cardiac gene expression pattern is unclear ...
Csonka, Csaba, Csont, Tamás Bálint, Fekete, Veronika, Ferdinandy, Péter, Gyémánt, Nóra, Kocsis-Fodor, Gabriella, Pipis, Judit, Puskás, László, Szűcs, Gergő, Sárközy, Márta, Zvara, Ágnes   +10 more
core   +3 more sources

Construction of Active Sites‐Accessible Au8 Clusters for Intensive Tumor Pyroptosis

Aggregate, EarlyView.
Ethynylferrocene (EFc) was utilized to engineer molecular‐like gold nanoclusters (NCs) with accessibly catalytic centers, resulting in NCs exhibiting excellent peroxidase‐like activity and the ability to radiosensitize, leading to the production of intracellular oxidative stress and activation of pyroptosis.
Qiu‐Xu Zang, Wei‐Tong Chen, Wenjing Zhang, Zhao‐Yang Wang, Xi‐Yan Dong, Runping Han, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Adipocytes cause leukemia cell resistance to daunorubicin via oxidative stress response. [PDF]

, 2016
Adipocytes promote cancer progression and impair treatment, and have been shown to protect acute lymphoblastic leukemia (ALL) cells from chemotherapies. Here we investigate whether this protection is mediated by changes in oxidative stress.
Behan, James W, Heisterkamp, Nora, Ji, Lingyun, Mittelman, Steven D, Parmentier, Jean-Hugues, Sheng, Xia, Tucci, Jonathan   +6 more
core   +1 more source

Interfacial Engineering of Pillararene‐Modified Ceria Nanoparticles for Regulable Enhanced Sonodynamic Therapy

Aggregate, EarlyView.
The innovation of this work lies in the use of supramolecular interfacial effect of pillararene (CP5) to regulate the performance of CeOx by promoting the charge separation and transportation, which can enhance the SDT efficacy by large ROS generation and TME regulation.
Congcong Wang, Yanan Guo, Guoying Tan, Wanrong Kang, Wenjia Guo, Nan Song, Yu Tang   +6 more
wiley   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

A hepatoprotective experiment on taro vegetable (Colocasia esculenta (L.) Schott) flower employing animal models by mitigating oxidative stress

Animal Models and Experimental Medicine, EarlyView.
The antioxidant efficacy of Colocasia esculenta flower’s methanolic extract was assessed using 2,2′‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulfonic) (ABTS) and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) scavenging assay. The hepatoprotective effect was investigated by assessing liver injury indicators (amino transferase [ALT], aspartate amino transferase [AST],
Mahathir Mohammad, Fahmida Tasnim Richi, Rabiul Hossain, Md. Arafat, Pair Ahmed Jiko, Nazim Uddin Emon, Sayed Al Hossain Rabbi, Tirtha Khastagir, Md. Hemayet Hossain, Safaet Alam   +9 more
wiley   +1 more source