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Clinica Chimica Acta, 2020
Glycated hemoglobin (HbA1c) is the reference test for long-term glucose monitoring. However, HbA1c is not recommended in several situations such as hemoglobinopathies, pregnancy or chronic kidney disease. The quantification of serum glycated albumin (GA) can serve as an alternative in these situations.
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Glycated hemoglobin (HbA1c) is the reference test for long-term glucose monitoring. However, HbA1c is not recommended in several situations such as hemoglobinopathies, pregnancy or chronic kidney disease. The quantification of serum glycated albumin (GA) can serve as an alternative in these situations.
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Glycated albumin and diabetes mellitus
Biochimica et Biophysica Acta (BBA) - General Subjects, 2013Diabetes is a growing worldwide problem that is strongly associated with atherosclerosis. Screening and intervention for diabetes in the earliest stages are advocated for the prevention of diabetic complications and cardiovascular disease.This review gives a background of and discusses the potential clinical utility of glycated albumin (GA) in diabetes.
Norihiro, Furusyo, Jun, Hayashi
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A pharmacokinetic model for the glycation of albumin
Journal of Pharmacokinetics and Pharmacodynamics, 2012Glycated haemoglobin (HbA1c) concentrations can be falsely lowered in circumstances when red blood cell (RBC) survival is reduced, e.g. in patients with chronic kidney disease (CKD). Glycated albumin (GA) has been suggested as an alternative marker of glycaemic control in these patients since it is independent of the RBC life span.
Oskar, Alskär +2 more
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Journal of Diabetes and its Complications, 2016
The glycation gap (G-gap) is an empirical measure of the extent of the difference between HbA1C and fructosamine levels. Several studies have shown that the presence of a G-gap is linked to diabetic nephropathy, but possible artifacts caused by dependence of the fructosamine level on the extent of serum protein metabolism require careful consideration.
Mee Kyoung, Kim +4 more
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The glycation gap (G-gap) is an empirical measure of the extent of the difference between HbA1C and fructosamine levels. Several studies have shown that the presence of a G-gap is linked to diabetic nephropathy, but possible artifacts caused by dependence of the fructosamine level on the extent of serum protein metabolism require careful consideration.
Mee Kyoung, Kim +4 more
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Glycated albumin and glycated hemoglobin levels in normal pregnancy
Biochemical Medicine and Metabolic Biology, 1988Glycated albumin levels showed a progressive increase during normal pregnancy. The mean values (mole hexose/mole protein) were 1.68 +/- 0.27 (n = 15) in nonpregnant women, 1.83 +/- 0.21 (n = 11) in first trimester, 2.00 +/- 0.41 (n = 13) in second trimester, and 2.42 +/- 0.49 (n = 15) in third trimester.
K B, Rai, A, Kumar, T N, Pattabiraman
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Structural and glycation site changes of albumin in diabetic patient with very high glycated albumin
Clinica Chimica Acta, 2007Glycated albumin (GA) has been utilized to monitor mid-term glycemic control, and reflects the status of blood glucose more rapidly and effectively than hemoglobin A(1c) (HbA(1c)). To examine the relationship between GA level and structural changes or glycation sites of albumin, we analyzed pre- and post-treatment samples from a diabetic patient with ...
Reiko, Kisugi +9 more
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Glycated albumin; clinical usefulness
Clinica Chimica Acta, 2014The main purpose of treating diabetes is to prevent the onset and progression of diabetic chronic complications. Since the mechanism of onset of chronic complications is still not well understood, the main strategy to achieve this purpose is to bring plasma glucose levels as close as possible to those in healthy subjects and maintain good glycemic ...
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A facile route to glycated albumin detection
Talanta, 2018In this paper we propose an easy way to detect the glycated form of human serum albumin which is biomarker for several diseases such as diabetes and Alzheimer. The detection platform is a label free impedimetric immunosensor, in which we used a monoclonal human serum albumin antibody as a bioreceptor and electrochemical impedance as a transducing ...
Bohli, Nadra +5 more
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Electrochemical Biosensor for the Detection of Glycated Albumin
Current Alzheimer Research, 2017Background: Alzheimer’s disease (AD) is the most common form of dementia. The process of AD can begin 20 years before any symptom of cognitive loss. Thus, the development of systems for early diagnosis and prevention is very important. The mechanism of AD is still under debate.
Edyta, Mikula +6 more
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