Results 1 to 10 of about 8,345 (146)

Luminescent probe method in the study of the interaction of glycated human serum albuminwith non-glycated human serum albumin [PDF]

Известия Саратовского университета. Новая серия: Физика, 2023
Background and Objectives: The development and functioning of all living beings ends with the inevitable aging process, as a result of which the activity of all organs and the body as a whole is suppressed, which leads to imminent death.
Kochubey, Vyacheslav Ivanovich, Pravdin, Aleksander Borisovich, Melnikov, Andrey G., Bykov, Denis Andreevich, Melnikov, Gennady V.   +4 more
doaj   +2 more sources

Silver nanoparticle interactions with glycated and non-glycated human serum albumin mediate toxicity

Frontiers in Toxicology, 2023
Introduction: Biomolecules bind to and transform nanoparticles, mediating their fate in biological systems. Despite over a decade of research into the protein corona, the role of protein modifications in mediating their interaction with nanomaterials ...
Hee-Yon Park, Christopher Chung, Madeline K. Eiken, Karl V. Baumgartner, Kira M. Fahy, Kaitlyn Q. Leung, Evangelia Bouzos, Prashanth Asuri, Korin E. Wheeler, Kathryn R. Riley   +9 more
doaj   +4 more sources

Changes in Glycated Human Serum Albumin Binding Affinity for Losartan in the Presence of Fatty Acids In Vitro Spectroscopic Analysis

Molecules, 2022
Conformational changes in human serum albumin due to numerous modifications that affect its stability and biological activity should be constantly monitored, especially in elderly patients and those suffering from chronic diseases (which include diabetes,
Agnieszka Szkudlarek, Jadwiga Pożycka, Karolina Kulig, Aleksandra Owczarzy, Wojciech Rogóż, Małgorzata Maciążek-Jurczyk   +5 more
doaj   +3 more sources

Binding of tolbutamide to glycated human serum albumin [PDF]

Journal of Pharmaceutical and Biomedical Analysis, 2011
The presence of elevated levels of glucose in blood during diabetes can lead to the non-enzymatic glycation of serum proteins such as human serum albumin (HSA). This study examined the changes that occur in binding of the sulfonylurea drug tolbutamide to HSA as the level of glycation for this protein was increased.
K S Joseph, Jeanethe Anguizola, David S Hage   +2 more
exaly   +3 more sources

Electrochemical Quantification of Glycated and Non-glycated Human Serum Albumin in Synthetic Urine [PDF]

ACS Applied Materials & Interfaces, 2019
A polymer-based electrode capable of specific detection of human serum albumin, and its glycated derivatives, is described. The sensor is constructed from a glass microscope slide coated with a synthesized, polythiophene film bearing a protected, iminodiacetic acid motif.
Aisha Attár, Mark B Richardson, Gaetano Speciale   +2 more
exaly   +6 more sources

Spectroscopic Technique-Based Comparative Investigation on the Interaction of Theaflavins with Native and Glycated Human Serum Albumin

Molecules, 2019
Theaflavin is a kind of multi-pharmacological and health beneficial black tea factor. The aim of this study is to investigate the mechanisms by which theaflavin interacts with glycosylated and non-glycosylated serum albumins and compares their binding ...
Jinhui Xu, Mengyuan Wang, Yizhe Zheng, Lin Tang   +3 more
doaj   +3 more sources

SERS Sensor for Human Glycated Albumin Direct Assay Based on Machine Learning Methods

Chemosensors, 2022
In this study, a non-labeled sensor system for direct determining human glycated albumin levels for medical application is proposed. Using machine learning methods applied to surface-enhanced Raman scattering (SERS) spectra of human glycated albumin and ...
Ekaterina A. Slipchenko, Irina A. Boginskaya, Robert R. Safiullin, Ilya A. Ryzhikov, Marina V. Sedova, Konstantin N. Afanasev, Natalia L. Nechaeva, Ilya N. Kurochkin, Alexander M. Merzlikin, Andrey N. Lagarkov   +9 more
doaj   +3 more sources

A biophysical comparison of human serum albumin to be glycated in vivo and in vitro [PDF]

Journal of Medical Biochemistry, 2011
The glycation process includes the arrangement of proteins with chemically reversible early glycation products, Schiff bases and Amadori adducts. These early products endure slow and complex rearrangements to create advanced glycation end-products (AGEs)
Sattarahmady Naghmeh, Moosavi-Movahedi Ali A., Habibi-Rezaei Mehran   +2 more
doaj   +2 more sources

Influence of Piracetam on Gliclazide—Glycated Human Serum Albumin Interaction. A Spectrofluorometric Study [PDF]

Molecules, 2018
Advanced Glycation End-Products (AGEs) are created in the last step of protein glycation and can be a factor in aging and in the development or worsening of many degenerative diseases (diabetes, chronic kidney disease, atherosclerosis, Alzheimer’s ...
Agnieszka Szkudlarek, Jadwiga Pożycka, Małgorzata Maciążek-Jurczyk   +2 more
doaj   +4 more sources

Chromatographic analysis of acetohexamide binding to glycated human serum albumin [PDF]

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2010
Acetohexamide is a drug used to treat type II diabetes and is tightly bound to the protein human serum albumin (HSA) in the circulation. It has been proposed that the binding of some drugs with HSA can be affected by the non-enzymatic glycation of this protein.
K S Joseph, Jeanethe Anguizola, David S Hage   +2 more
exaly   +3 more sources