Results 1 to 10 of about 27,699 (161)

In Vitro Investigations of Acetohexamide Binding to Glycated Serum Albumin in the Presence of Fatty Acid [PDF]

Molecules, 2020
The interaction of drugs with human serum albumin (HSA) is an important element of therapy. Albumin affects the distribution of the drug substance in the body, as well as its pharmacokinetic and pharmacodynamic properties.
Agnieszka Szkudlarek, Michał Wilk, Małgorzata Maciążek-Jurczyk   +2 more
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Effect of Temperature on Tolbutamide Binding to Glycated Serum Albumin [PDF]

Molecules, 2017
Glycation process occurs in protein and becomes more pronounced in diabetes when an increased amount of reducing sugar is present in bloodstream. Glycation of protein may cause conformational changes resulting in the alterations of its binding properties
Agnieszka Szkudlarek, Danuta Pentak, Anna Ploch, Jadwiga Pożycka, Małgorzata Maciążek-Jurczyk   +4 more
doaj   +2 more sources

Spectroscopic Technique-Based Comparative Investigation on the Interaction of Theaflavins with Native and Glycated Human Serum Albumin

Molecules, 2019
Theaflavin is a kind of multi-pharmacological and health beneficial black tea factor. The aim of this study is to investigate the mechanisms by which theaflavin interacts with glycosylated and non-glycosylated serum albumins and compares their binding ...
Jinhui Xu, Mengyuan Wang, Yizhe Zheng, Lin Tang   +3 more
doaj   +3 more sources

Albumin does not induce IL-6 release and toll-like receptor activation in vitro: Role of endotoxin contamination and biochemical modifications [PDF]

BBA Advances
Human serum albumin (HSA) is widely used in both clinical and research settings, yet its potential to stimulate immune responses remains poorly understood.
Margret Paar, Vera H. Fengler, Martina Schweiger, Christine Rossmann, Christoph Nusshold, Martina Mairold, Doris Payerl, Gerhard Cvirn, Karl Oettl   +8 more
doaj   +2 more sources

Luminescent probe method in the study of the interaction of glycated human serum albuminwith non-glycated human serum albumin [PDF]

Известия Саратовского университета. Новая серия: Физика, 2023
Background and Objectives: The development and functioning of all living beings ends with the inevitable aging process, as a result of which the activity of all organs and the body as a whole is suppressed, which leads to imminent death.
Kochubey, Vyacheslav Ivanovich, Pravdin, Aleksander Borisovich, Melnikov, Andrey G., Bykov, Denis Andreevich, Melnikov, Gennady V.   +4 more
doaj   +1 more source

Silver nanoparticle interactions with glycated and non-glycated human serum albumin mediate toxicity

Frontiers in Toxicology, 2023
Introduction: Biomolecules bind to and transform nanoparticles, mediating their fate in biological systems. Despite over a decade of research into the protein corona, the role of protein modifications in mediating their interaction with nanomaterials ...
Hee-Yon Park, Christopher Chung, Madeline K. Eiken, Karl V. Baumgartner, Kira M. Fahy, Kaitlyn Q. Leung, Evangelia Bouzos, Prashanth Asuri, Korin E. Wheeler, Kathryn R. Riley   +9 more
doaj   +1 more source

Changes in Glycated Human Serum Albumin Binding Affinity for Losartan in the Presence of Fatty Acids In Vitro Spectroscopic Analysis

Molecules, 2022
Conformational changes in human serum albumin due to numerous modifications that affect its stability and biological activity should be constantly monitored, especially in elderly patients and those suffering from chronic diseases (which include diabetes,
Agnieszka Szkudlarek, Jadwiga Pożycka, Karolina Kulig, Aleksandra Owczarzy, Wojciech Rogóż, Małgorzata Maciążek-Jurczyk   +5 more
doaj   +1 more source

Biophysical Characterisation of Amadori Modified Human Serum Albumin: A Prognostic Biomarker for Diabetic Complications [PDF]

Journal of Clinical and Diagnostic Research, 2022
Introduction: Glycation of biological macromolecules particularly protein leads to the generation of early and Advanced Glycation End (AGE) products. The interest in early glycation of protein is driven due to the fact of Amadori modified proteins having
Binish Arif, Zubair Ahmad, Gulzar Ahmad Bhat, Syed Mudassar, Khursheed Aalam   +4 more
doaj   +1 more source

SERS Sensor for Human Glycated Albumin Direct Assay Based on Machine Learning Methods

Chemosensors, 2022
In this study, a non-labeled sensor system for direct determining human glycated albumin levels for medical application is proposed. Using machine learning methods applied to surface-enhanced Raman scattering (SERS) spectra of human glycated albumin and ...
Ekaterina A. Slipchenko, Irina A. Boginskaya, Robert R. Safiullin, Ilya A. Ryzhikov, Marina V. Sedova, Konstantin N. Afanasev, Natalia L. Nechaeva, Ilya N. Kurochkin, Alexander M. Merzlikin, Andrey N. Lagarkov   +9 more
doaj   +1 more source

Direct Detection of Glycated Human Serum Albumin and Hyperglycosylated IgG3 in Serum, by MALDI-ToF Mass Spectrometry, as a Predictor of COVID-19 Severity

Diagnostics, 2022
The prefusion spike protein of SARS-CoV-2 binds advanced glycation end product (AGE)-glycated human serum albumin (HSA) and a higher mass (hyperglycosylated/glycated) immunoglobulin (Ig) G3, as determined by matrix assisted laser desorption mass ...
Ray K. Iles, Jason K. Iles, Jonathan Lacey, Anna Gardiner, Raminta Zmuidinaite   +4 more
doaj   +1 more source