Results 31 to 40 of about 19,474 (199)
A Carbon-Based Antifouling Nano-Biosensing Interface for Label-Free POCT of HbA1c
Biosensors, 2021 Electrochemical biosensing relies on electron transport on electrode surfaces. However, electrode inactivation and biofouling caused by a complex biological sample severely decrease the efficiency of electron transfer and the specificity of biosensing ...
Zhenhua Li +4 more
doaj +1 more source
Evaluation of Glycated Albumin (GA) and GA/Hba1c Ratio for Diagnosis of Diabetes and Glycemic Control: A Comprehensive Review [PDF]
, 2017 Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic high blood glucose concentrations (hyperglycemia). When it is left untreated or improperly managed, it can lead to acute complications including diabetic ketoacidosis and ...
Abdolrahim, Mojgan +6 more
core +3 more sources
Review: Glycation of human serum albumin
Clinica Chimica Acta, 2013 Glycation involves the non-enzymatic addition of reducing sugars and/or their reactive degradation products to amine groups on proteins. This process is promoted by the presence of elevated blood glucose concentrations in diabetes and occurs with various proteins that include human serum albumin (HSA).
Anguizola, Jeanethe +7 more
openaire +3 more sources
Dietary Polyphenols and Periodontitis—A Mini-Review of Literature [PDF]
, 2018 Periodontitis, which is a chronic infection and disease of the periodontium, is a significant global health burden and is linked to other chronic health conditions such as diabetes and cardiovascular diseases.
Basu, Arpita +2 more
core +2 more sources
Papaverine increases human serum albumin glycation [PDF]
Journal of Biological Physics, 2014 Glycation is a non-enzymatic reaction that is initiated by the primary addition of sugars to amino groups of proteins. In the early phase of glycation, the synthesis of intermediates leads to formation of Amadori compounds. In the last phase, advanced glycation end products (AGE) are irreversibly formed following a complex cascade of reactions.
openaire +2 more sources
Molecules, 2020 The interaction of drugs with human serum albumin (HSA) is an important element of therapy. Albumin affects the distribution of the drug substance in the body, as well as its pharmacokinetic and pharmacodynamic properties.
Agnieszka Szkudlarek +2 more
doaj +1 more source
NMR analysis of synthetic human serum albumin alpha-helix 28 identifies structural distortion upon amadori modification [PDF]
, 2005 The non-enzymatic reaction between reducing sugars and long-lived proteins in vivo results in the formation of glycation and advanced glycation end products, which alter the properties of proteins including charge, helicity, and their tendency to ...
Howard, Mark J. +1 more
core +1 more source
Methylglyoxal induces platelet hyperaggregation and reduces thrombus stability by activating PKC and inhibiting PI3K/Akt pathway [PDF]
, 2013 Diabetes is characterized by a dysregulation of glucose homeostasis and platelets from patients with diabetes are known to be hyper-reactive and contribute to the accelerated development of vascular diseases.
Elgheznawy, Amro +4 more
core +6 more sources
Liraglutide and renal outcomes in type 2 diabetes [PDF]
, 2017 In a randomized, controlled trial that compared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular risk who were receiving usual care, we found that liraglutide resulted in lower risks ...
Brown-Frandsen, Kirstine +9 more
core +2 more sources
Molecules, 2017 Serum albumin is exposed to numerous structural modifications which affect its stability and activity. Glycation is one of the processes leading to the loss of the original properties of the albumin and physiological function disorder.
Agnieszka Szkudlarek +4 more
doaj +1 more source