Results 11 to 20 of about 19,474 (199)

Development of a Novel ssDNA Sequence for a Glycated Human Serum Albumin and Construction of a Simple Aptasensor System Based on Reduced Graphene Oxide (rGO) [PDF]

Biosensors, 2020
Diabetes is one of the top 10 global causes of death. About one in 11 global adults have diabetes. As the disease progresses, the mortality rate increases, and complications can develop.
A-Ru Kim, Yeongmi Choi, Sang-Heon Kim, Hyun-Seok Moon, Jae-Ho Ko, Moon-Young Yoon   +5 more
doaj   +4 more sources

Direct Detection of Glycated Human Serum Albumin and Hyperglycosylated IgG3 in Serum, by MALDI-ToF Mass Spectrometry, as a Predictor of COVID-19 Severity [PDF]

Diagnostics, 2022
The prefusion spike protein of SARS-CoV-2 binds advanced glycation end product (AGE)-glycated human serum albumin (HSA) and a higher mass (hyperglycosylated/glycated) immunoglobulin (Ig) G3, as determined by matrix assisted laser desorption mass ...
Ray K. Iles, Jason K. Iles, Jonathan Lacey, Anna Gardiner, Raminta Zmuidinaite   +4 more
doaj   +2 more sources

DFT and molecular dynamics studies of astaxanthin-metal ions (Cu2+ and Zn2+) complex to prevent glycated human serum albumin from possible unfolding [PDF]

Heliyon, 2021
Glycated human serum albumin (gHSA) undergoes conformational changes of proteins caused by free radicals. The glycation process results in a reduced ability of albumin as an endogenous scavenger in diabetes mellitus type 2 (T2DM) patients.
Syahputra Wibowo, Sri Widyarti, Akhmad Sabarudin, Djoko Wahono Soeatmadji, Sutiman Bambang Sumitro   +4 more
doaj   +2 more sources

Rapid glycation with D-ribose induces globular amyloid-like aggregations of BSA with high cytotoxicity to SH-SY5Y cells [PDF]

BMC Cell Biology, 2009
Background D-ribose in cells and human serum participates in glycation of proteins resulting in advanced glycation end products (AGEs) that affect cell metabolism and induce cell death.
Ge Lin, Chen Ji, Chen Lan, Wei Yan, He Rong   +4 more
doaj   +2 more sources

Studies of drug interactions with glycated human serum albumin by high-performance affinity chromatography [PDF]

Reviews in Analytical Chemistry, 2014
Diabetes is a health condition associated with the elevated levels of glucose in the bloodstream and affects 366 million people worldwide. Type II diabetes is often treated with sulfonylurea drugs, which are known to bind tightly in the blood to the ...
Matsuda Ryan, Kye So-Hwang, Anguizola Jeanethe, Hage David S.   +3 more
doaj   +2 more sources

From Cure to Complexity: Post-SVR Liver and Metabolic Trajectories in Diabetic Patients. [PDF]

Liver Int
ABSTRACT Background and Aims The long‐term impact of HCV cure on hepatic and metabolic outcomes in patients with type 2 diabetes (T2D) remains insufficiently defined. This study evaluated T2D‐related vascular complications, liver disease progression and overall survival over 9 years of follow‐up, also exploring genetic variability contribution ...
Asero C, Franzè MS, Maltese T, La Spada A, Lombardo D, Grisanti C, Russo G, Giandalia A, Pitrone C, Filomia R, Caccamo G, Saitta C, Licata A, Pollicino T, Cacciola I.   +14 more
europepmc   +2 more sources

Diabetic Glycation of Human Serum Albumin Affects Its Immunogenicity

Biomolecules
Advanced glycation end-products (AGEs) are products of a non-enzymatic reaction between amino acids and reducing sugars. Glycated human serum albumin (HSA) increases in diabetics as a consequence of elevated blood glucose levels and glycating metabolites
Cresci-Anne C. C. Croes, Marialena Chrysanthou, Tamara Hoppenbrouwers, Harry Wichers, Jaap Keijer, Huub F. J. Savelkoul, Malgorzata Teodorowicz   +6 more
doaj   +3 more sources

Albumin does not induce IL-6 release and toll-like receptor activation in vitro: Role of endotoxin contamination and biochemical modifications [PDF]

BBA Advances
Human serum albumin (HSA) is widely used in both clinical and research settings, yet its potential to stimulate immune responses remains poorly understood.
Margret Paar, Vera H. Fengler, Martina Schweiger, Christine Rossmann, Christoph Nusshold, Martina Mairold, Doris Payerl, Gerhard Cvirn, Karl Oettl   +8 more
doaj   +2 more sources

Unveiling the anti-glycation properties of acetylsalicylic acid: targeted inhibition of albumin glycation [PDF]

Amino Acids
Glycation due to increased blood sugar levels aggravates diabetic complications. Glycation hampers the structural and functional integrity of human serum albumin (HSA). Acetylsalicylic acid (ASA)/aspirin exhibits anti-glycation properties.
Rashmi Tupe, Ankita Durge, Ashwini Jagdale   +2 more
doaj   +2 more sources

Effect of Papaverine on Human Serum Albumin Glycation

Journal of Medicinal Plants, 2012
Background: Glycation is a non enzymatic reaction initiated by the primary addition of sugar to the amino groups of proteins.In the early stage of glyction, the synthesis of intermediates leading to formation of Amadori compounds occurs.
A Ahmadzadeh, M Feizie, R Ghafarzadegan
doaj   +1 more source